Optimization of Printing Parameters for Digital Light Processing 3D Printing of Hollow Microneedle Arrays

3D printing is an emerging technology aiming towards personalized drug delivery, among many other applications. Microneedles (MN) are a viable method for transdermal drug delivery that is becoming more popular for delivery through the skin. However, there is a need for a faster fabrication process w...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Essyrose Mathew, Giulia Pitzanti, Ana L. Gomes dos Santos, Dimitrios A. Lamprou
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hollow microneedles transdermal drug delivery 3D printing additive manufacturing digital light processing emerging technologies Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/3ef3b84e0b4d4261806acab18b34d402
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3ef3b84e0b4d4261806acab18b34d402
record_format	dspace
spelling	oai:doaj.org-article:3ef3b84e0b4d4261806acab18b34d4022021-11-25T18:41:02ZOptimization of Printing Parameters for Digital Light Processing 3D Printing of Hollow Microneedle Arrays10.3390/pharmaceutics131118371999-4923https://doaj.org/article/3ef3b84e0b4d4261806acab18b34d4022021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1837https://doaj.org/toc/1999-49233D printing is an emerging technology aiming towards personalized drug delivery, among many other applications. Microneedles (MN) are a viable method for transdermal drug delivery that is becoming more popular for delivery through the skin. However, there is a need for a faster fabrication process with potential for easily exploring different geometries of MNs. In the current study, a digital light processing (DLP) method of 3D printing for fabrication of hollow MN arrays using commercial UV curable resin was proposed. Print quality was optimised by assessing the effect of print angle on needle geometries. Mechanical testing of MN arrays was conducted using a texture analyser. Angled prints were found to produce prints with geometries closer to the CAD designs. Curing times were found to affect the mechanical strength of MNs, with arrays not breaking when subjected to 300 N of force but were bent. Overall, DLP process produced hollow MNs with good mechanical strength and depicts a viable, quick, and efficient method for the fabrication of hollow MN arrays.Essyrose MathewGiulia PitzantiAna L. Gomes dos SantosDimitrios A. LamprouMDPI AGarticlehollow microneedlestransdermal drug delivery3D printingadditive manufacturingdigital light processingemerging technologiesPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1837, p 1837 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hollow microneedles transdermal drug delivery 3D printing additive manufacturing digital light processing emerging technologies Pharmacy and materia medica RS1-441
spellingShingle	hollow microneedles transdermal drug delivery 3D printing additive manufacturing digital light processing emerging technologies Pharmacy and materia medica RS1-441 Essyrose Mathew Giulia Pitzanti Ana L. Gomes dos Santos Dimitrios A. Lamprou Optimization of Printing Parameters for Digital Light Processing 3D Printing of Hollow Microneedle Arrays
description	3D printing is an emerging technology aiming towards personalized drug delivery, among many other applications. Microneedles (MN) are a viable method for transdermal drug delivery that is becoming more popular for delivery through the skin. However, there is a need for a faster fabrication process with potential for easily exploring different geometries of MNs. In the current study, a digital light processing (DLP) method of 3D printing for fabrication of hollow MN arrays using commercial UV curable resin was proposed. Print quality was optimised by assessing the effect of print angle on needle geometries. Mechanical testing of MN arrays was conducted using a texture analyser. Angled prints were found to produce prints with geometries closer to the CAD designs. Curing times were found to affect the mechanical strength of MNs, with arrays not breaking when subjected to 300 N of force but were bent. Overall, DLP process produced hollow MNs with good mechanical strength and depicts a viable, quick, and efficient method for the fabrication of hollow MN arrays.
format	article
author	Essyrose Mathew Giulia Pitzanti Ana L. Gomes dos Santos Dimitrios A. Lamprou
author_facet	Essyrose Mathew Giulia Pitzanti Ana L. Gomes dos Santos Dimitrios A. Lamprou
author_sort	Essyrose Mathew
title	Optimization of Printing Parameters for Digital Light Processing 3D Printing of Hollow Microneedle Arrays
title_short	Optimization of Printing Parameters for Digital Light Processing 3D Printing of Hollow Microneedle Arrays
title_full	Optimization of Printing Parameters for Digital Light Processing 3D Printing of Hollow Microneedle Arrays
title_fullStr	Optimization of Printing Parameters for Digital Light Processing 3D Printing of Hollow Microneedle Arrays
title_full_unstemmed	Optimization of Printing Parameters for Digital Light Processing 3D Printing of Hollow Microneedle Arrays
title_sort	optimization of printing parameters for digital light processing 3d printing of hollow microneedle arrays
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3ef3b84e0b4d4261806acab18b34d402
work_keys_str_mv	AT essyrosemathew optimizationofprintingparametersfordigitallightprocessing3dprintingofhollowmicroneedlearrays AT giuliapitzanti optimizationofprintingparametersfordigitallightprocessing3dprintingofhollowmicroneedlearrays AT analgomesdossantos optimizationofprintingparametersfordigitallightprocessing3dprintingofhollowmicroneedlearrays AT dimitriosalamprou optimizationofprintingparametersfordigitallightprocessing3dprintingofhollowmicroneedlearrays
_version_	1718410827686477824

Optimization of Printing Parameters for Digital Light Processing 3D Printing of Hollow Microneedle Arrays

Ejemplares similares