Common Fundamentals of Psoriasis and Depression

Psoriasis is an inflammatory, immune-mediated disease that is frequently associated with psychological comorbidities such as depression. The stigma patients feel because of the appearance of their skin may contribute to the high psycho-social burden of psoriasis. However, there is emerging evidence...

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Autores principales:	Stefanie Hölsken, Frederik Krefting, Manfred Schedlowski, Wiebke Sondermann
Formato:	article
Lenguaje:	EN
Publicado:	Society for Publication of Acta Dermato-Venereologica 2021
Materias:	psoriasis depression psychological comorbidity inflammation pathophysiologic link depression screening tools Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/3ef4abb9880842ad8c24c6d1acbff7c5
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id	oai:doaj.org-article:3ef4abb9880842ad8c24c6d1acbff7c5
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spelling	oai:doaj.org-article:3ef4abb9880842ad8c24c6d1acbff7c52021-11-30T14:25:05ZCommon Fundamentals of Psoriasis and Depression10.2340/actadv.v101.5650001-55551651-2057https://doaj.org/article/3ef4abb9880842ad8c24c6d1acbff7c52021-11-01T00:00:00Zhttps://medicaljournalssweden.se/actadv/article/view/565https://doaj.org/toc/0001-5555https://doaj.org/toc/1651-2057 Psoriasis is an inflammatory, immune-mediated disease that is frequently associated with psychological comorbidities such as depression. The stigma patients feel because of the appearance of their skin may contribute to the high psycho-social burden of psoriasis. However, there is emerging evidence that overlapping biological mechanisms are, to a substantial degree, responsible for the close interaction between psoriasis and depression. Increased proinflammatory mediators, such as C-reactive protein or interleukin-6, are present in both psoriasis and depression, indicating that inflammation may represent a pathophysiological link between the diseases. Anti-inflammatory biologic therapies treat the clinical manifestations of psoriasis, but might also play a significant role in reducing associated depressive symptoms in patients with psoriasis. Comparison between single studies focusing on the change in depressive symptoms in psoriasis is limited by inconsistency in the depression screening tools applied. Stefanie HölskenFrederik KreftingManfred SchedlowskiWiebke SondermannSociety for Publication of Acta Dermato-Venereologicaarticlepsoriasisdepressionpsychological comorbidityinflammationpathophysiologic linkdepression screening toolsDermatologyRL1-803ENActa Dermato-Venereologica, Vol 101, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	psoriasis depression psychological comorbidity inflammation pathophysiologic link depression screening tools Dermatology RL1-803
spellingShingle	psoriasis depression psychological comorbidity inflammation pathophysiologic link depression screening tools Dermatology RL1-803 Stefanie Hölsken Frederik Krefting Manfred Schedlowski Wiebke Sondermann Common Fundamentals of Psoriasis and Depression
description	Psoriasis is an inflammatory, immune-mediated disease that is frequently associated with psychological comorbidities such as depression. The stigma patients feel because of the appearance of their skin may contribute to the high psycho-social burden of psoriasis. However, there is emerging evidence that overlapping biological mechanisms are, to a substantial degree, responsible for the close interaction between psoriasis and depression. Increased proinflammatory mediators, such as C-reactive protein or interleukin-6, are present in both psoriasis and depression, indicating that inflammation may represent a pathophysiological link between the diseases. Anti-inflammatory biologic therapies treat the clinical manifestations of psoriasis, but might also play a significant role in reducing associated depressive symptoms in patients with psoriasis. Comparison between single studies focusing on the change in depressive symptoms in psoriasis is limited by inconsistency in the depression screening tools applied.
format	article
author	Stefanie Hölsken Frederik Krefting Manfred Schedlowski Wiebke Sondermann
author_facet	Stefanie Hölsken Frederik Krefting Manfred Schedlowski Wiebke Sondermann
author_sort	Stefanie Hölsken
title	Common Fundamentals of Psoriasis and Depression
title_short	Common Fundamentals of Psoriasis and Depression
title_full	Common Fundamentals of Psoriasis and Depression
title_fullStr	Common Fundamentals of Psoriasis and Depression
title_full_unstemmed	Common Fundamentals of Psoriasis and Depression
title_sort	common fundamentals of psoriasis and depression
publisher	Society for Publication of Acta Dermato-Venereologica
publishDate	2021
url	https://doaj.org/article/3ef4abb9880842ad8c24c6d1acbff7c5
work_keys_str_mv	AT stefanieholsken commonfundamentalsofpsoriasisanddepression AT frederikkrefting commonfundamentalsofpsoriasisanddepression AT manfredschedlowski commonfundamentalsofpsoriasisanddepression AT wiebkesondermann commonfundamentalsofpsoriasisanddepression
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Common Fundamentals of Psoriasis and Depression

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