Rap1 can bypass the FAK-Src-Paxillin cascade to induce cell spreading and focal adhesion formation.

Rap1 can bypass the FAK-Src-Paxillin cascade to induce cell spreading and focal adhesion formation.

We developed new image analysis tools to analyse quantitatively the extracellular-matrix-dependent cell spreading process imaged by live-cell epifluorescence microscopy. Using these tools, we investigated cell spreading induced by activation of the small GTPase, Rap1. After replating and initial adh...

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Autores principales: Sarah H Ross, Emma Spanjaard, Anneke Post, Marjolein J Vliem, Hendy Kristyanto, Johannes L Bos, Johan de Rooij
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/3ef73f727ea84a80bc37a1e8f771963e
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