Cesarean Section Is Associated with Increased Peripheral and Central Adiposity in Young Adulthood: Cohort Study.

<h4>Background</h4>Cesarean section (CS) has been associated with obesity, measured by body mass index (BMI), in some studies. It has been hypothesized that this association, if causal, might be explained by changes in gut microbiota. However, little is known about whether CS is also ass...

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Autores principales:	Denise N Mesquita, Marco A Barbieri, Helena A S Goldani, Viviane C Cardoso, Marcelo Z Goldani, Gilberto Kac, Antônio A M Silva, Heloisa Bettiol
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3ef8ecd4f6ab4bd18d9fa1b32e47face
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spelling	oai:doaj.org-article:3ef8ecd4f6ab4bd18d9fa1b32e47face2021-11-18T07:39:47ZCesarean Section Is Associated with Increased Peripheral and Central Adiposity in Young Adulthood: Cohort Study.1932-620310.1371/journal.pone.0066827https://doaj.org/article/3ef8ecd4f6ab4bd18d9fa1b32e47face2013-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0066827https://doaj.org/toc/1932-6203<h4>Background</h4>Cesarean section (CS) has been associated with obesity, measured by body mass index (BMI), in some studies. It has been hypothesized that this association, if causal, might be explained by changes in gut microbiota. However, little is known about whether CS is also associated with increased adiposity as measured by indicators other than BMI.<h4>Objective</h4>To assess the association between CS and indicators of peripheral and central adiposity in young adults.<h4>Methods</h4>The study was conducted on 2,063 young adults aged 23 to 25 years from the 1978/79Ribeirão Preto birth cohort, São Paulo, Brazil. CS was the independent variable. The anthropometric indicators of adiposity were: waist circumference (WC), waist-height ratio (WHtR), waist-hip ratio (WHR), tricipital skinfold (TSF), and subscapular skinfold (SSF). The association between CS and indicators of adiposity was investigated using a Poisson model, with robust adjustment of variance and calculation of incidence rate ratio (IRR) with 95% confidence interval (95%CI), and adjustment for birth variables.<h4>Results</h4>Follow-up rate was 31.8%. The CS rate was 32%. Prevalences of increased WC, WHtR, WHR were 32.1%, 33.0% and 15.2%, respectively. After adjustment for birth variables, CS was associated with increased risk of adiposity when compared to vaginal delivery: 1.22 (95%CI 1.07; 1.39) for WC, 1.25 (95%CI 1.10;1.42) for WHtR, 1.45 (95%CI 1.18;1.79) for WHR, 1.36 (95%CI 1.04;1.78) for TSF, and 1.43 (95%CI 1.08;1.91) for SSF.<h4>Conclusion</h4>Subjects born by CS had a higher risk for increased peripheral and central adiposity during young adult age compared to those born by vaginal delivery. The association of CS with adiposity was consistently observed for all indicators and was robust after adjustment for a variety of early life confounders.Denise N MesquitaMarco A BarbieriHelena A S GoldaniViviane C CardosoMarcelo Z GoldaniGilberto KacAntônio A M SilvaHeloisa BettiolPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e66827 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Denise N Mesquita Marco A Barbieri Helena A S Goldani Viviane C Cardoso Marcelo Z Goldani Gilberto Kac Antônio A M Silva Heloisa Bettiol Cesarean Section Is Associated with Increased Peripheral and Central Adiposity in Young Adulthood: Cohort Study.
description	<h4>Background</h4>Cesarean section (CS) has been associated with obesity, measured by body mass index (BMI), in some studies. It has been hypothesized that this association, if causal, might be explained by changes in gut microbiota. However, little is known about whether CS is also associated with increased adiposity as measured by indicators other than BMI.<h4>Objective</h4>To assess the association between CS and indicators of peripheral and central adiposity in young adults.<h4>Methods</h4>The study was conducted on 2,063 young adults aged 23 to 25 years from the 1978/79Ribeirão Preto birth cohort, São Paulo, Brazil. CS was the independent variable. The anthropometric indicators of adiposity were: waist circumference (WC), waist-height ratio (WHtR), waist-hip ratio (WHR), tricipital skinfold (TSF), and subscapular skinfold (SSF). The association between CS and indicators of adiposity was investigated using a Poisson model, with robust adjustment of variance and calculation of incidence rate ratio (IRR) with 95% confidence interval (95%CI), and adjustment for birth variables.<h4>Results</h4>Follow-up rate was 31.8%. The CS rate was 32%. Prevalences of increased WC, WHtR, WHR were 32.1%, 33.0% and 15.2%, respectively. After adjustment for birth variables, CS was associated with increased risk of adiposity when compared to vaginal delivery: 1.22 (95%CI 1.07; 1.39) for WC, 1.25 (95%CI 1.10;1.42) for WHtR, 1.45 (95%CI 1.18;1.79) for WHR, 1.36 (95%CI 1.04;1.78) for TSF, and 1.43 (95%CI 1.08;1.91) for SSF.<h4>Conclusion</h4>Subjects born by CS had a higher risk for increased peripheral and central adiposity during young adult age compared to those born by vaginal delivery. The association of CS with adiposity was consistently observed for all indicators and was robust after adjustment for a variety of early life confounders.
format	article
author	Denise N Mesquita Marco A Barbieri Helena A S Goldani Viviane C Cardoso Marcelo Z Goldani Gilberto Kac Antônio A M Silva Heloisa Bettiol
author_facet	Denise N Mesquita Marco A Barbieri Helena A S Goldani Viviane C Cardoso Marcelo Z Goldani Gilberto Kac Antônio A M Silva Heloisa Bettiol
author_sort	Denise N Mesquita
title	Cesarean Section Is Associated with Increased Peripheral and Central Adiposity in Young Adulthood: Cohort Study.
title_short	Cesarean Section Is Associated with Increased Peripheral and Central Adiposity in Young Adulthood: Cohort Study.
title_full	Cesarean Section Is Associated with Increased Peripheral and Central Adiposity in Young Adulthood: Cohort Study.
title_fullStr	Cesarean Section Is Associated with Increased Peripheral and Central Adiposity in Young Adulthood: Cohort Study.
title_full_unstemmed	Cesarean Section Is Associated with Increased Peripheral and Central Adiposity in Young Adulthood: Cohort Study.
title_sort	cesarean section is associated with increased peripheral and central adiposity in young adulthood: cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/3ef8ecd4f6ab4bd18d9fa1b32e47face
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Cesarean Section Is Associated with Increased Peripheral and Central Adiposity in Young Adulthood: Cohort Study.

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