Anti-obesity effect of Lactobacillus gasseri BNR17 in high-sucrose diet-induced obese mice.

Previously, we reported that Lactobacillus gasseri BNR17 (BNR17), a probiotic strain isolated from human breast milk, inhibited increases in body weight and adipocyte tissue weight in high-sucrose diet-fed Sprague-Dawley (SD) rats and reduced glucose levels in type 2 diabetes mice. In the current st...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ji-Hee Kang, Sung-Il Yun, Mi-Hee Park, Jun-Hong Park, So-Young Jeong, Han-Oh Park
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3ef9a22057d944bda64e9f736c5bc924
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3ef9a22057d944bda64e9f736c5bc924
record_format	dspace
spelling	oai:doaj.org-article:3ef9a22057d944bda64e9f736c5bc9242021-11-18T07:59:32ZAnti-obesity effect of Lactobacillus gasseri BNR17 in high-sucrose diet-induced obese mice.1932-620310.1371/journal.pone.0054617https://doaj.org/article/3ef9a22057d944bda64e9f736c5bc9242013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23382926/?tool=EBIhttps://doaj.org/toc/1932-6203Previously, we reported that Lactobacillus gasseri BNR17 (BNR17), a probiotic strain isolated from human breast milk, inhibited increases in body weight and adipocyte tissue weight in high-sucrose diet-fed Sprague-Dawley (SD) rats and reduced glucose levels in type 2 diabetes mice. In the current study, we conducted further experiments to extend these observations and elucidate the mechanism involved. C57BL/6J mice received a normal diet, high-sucrose diet or high-sucrose diet containing L. gasseri BNR17 (10(9) or 10(10) CFU) for 10 weeks. The administration of L. gasseri BNR17 significantly reduced the body weight and white adipose tissue weight regardless of the dose administered. In BNR17-fed groups, mRNA levels of fatty acid oxidation-related genes (ACO, CPT1, PPARα, PPARδ) were significantly higher and those of fatty acid synthesis-related genes (SREBP-1c, ACC) were lower compared to the high-sucrose-diet group. The expression of GLUT4, main glucose transporter-4, was elevated in BNR17-fed groups. L. gasseri BNR17 also reduced the levels of leptin and insulin in serum. These results suggest that the anti-obesity actions of L. gasseri BNR17 can be attributed to elevated expression of fatty acid oxidation-related genes and reduced levels of leptin. Additionally, data suggested the anti-diabetes activity of L. gasseri BNR17 may be to due elevated GLUT4 and reduced insulin levels.Ji-Hee KangSung-Il YunMi-Hee ParkJun-Hong ParkSo-Young JeongHan-Oh ParkPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e54617 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ji-Hee Kang Sung-Il Yun Mi-Hee Park Jun-Hong Park So-Young Jeong Han-Oh Park Anti-obesity effect of Lactobacillus gasseri BNR17 in high-sucrose diet-induced obese mice.
description	Previously, we reported that Lactobacillus gasseri BNR17 (BNR17), a probiotic strain isolated from human breast milk, inhibited increases in body weight and adipocyte tissue weight in high-sucrose diet-fed Sprague-Dawley (SD) rats and reduced glucose levels in type 2 diabetes mice. In the current study, we conducted further experiments to extend these observations and elucidate the mechanism involved. C57BL/6J mice received a normal diet, high-sucrose diet or high-sucrose diet containing L. gasseri BNR17 (10(9) or 10(10) CFU) for 10 weeks. The administration of L. gasseri BNR17 significantly reduced the body weight and white adipose tissue weight regardless of the dose administered. In BNR17-fed groups, mRNA levels of fatty acid oxidation-related genes (ACO, CPT1, PPARα, PPARδ) were significantly higher and those of fatty acid synthesis-related genes (SREBP-1c, ACC) were lower compared to the high-sucrose-diet group. The expression of GLUT4, main glucose transporter-4, was elevated in BNR17-fed groups. L. gasseri BNR17 also reduced the levels of leptin and insulin in serum. These results suggest that the anti-obesity actions of L. gasseri BNR17 can be attributed to elevated expression of fatty acid oxidation-related genes and reduced levels of leptin. Additionally, data suggested the anti-diabetes activity of L. gasseri BNR17 may be to due elevated GLUT4 and reduced insulin levels.
format	article
author	Ji-Hee Kang Sung-Il Yun Mi-Hee Park Jun-Hong Park So-Young Jeong Han-Oh Park
author_facet	Ji-Hee Kang Sung-Il Yun Mi-Hee Park Jun-Hong Park So-Young Jeong Han-Oh Park
author_sort	Ji-Hee Kang
title	Anti-obesity effect of Lactobacillus gasseri BNR17 in high-sucrose diet-induced obese mice.
title_short	Anti-obesity effect of Lactobacillus gasseri BNR17 in high-sucrose diet-induced obese mice.
title_full	Anti-obesity effect of Lactobacillus gasseri BNR17 in high-sucrose diet-induced obese mice.
title_fullStr	Anti-obesity effect of Lactobacillus gasseri BNR17 in high-sucrose diet-induced obese mice.
title_full_unstemmed	Anti-obesity effect of Lactobacillus gasseri BNR17 in high-sucrose diet-induced obese mice.
title_sort	anti-obesity effect of lactobacillus gasseri bnr17 in high-sucrose diet-induced obese mice.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/3ef9a22057d944bda64e9f736c5bc924
work_keys_str_mv	AT jiheekang antiobesityeffectoflactobacillusgasseribnr17inhighsucrosedietinducedobesemice AT sungilyun antiobesityeffectoflactobacillusgasseribnr17inhighsucrosedietinducedobesemice AT miheepark antiobesityeffectoflactobacillusgasseribnr17inhighsucrosedietinducedobesemice AT junhongpark antiobesityeffectoflactobacillusgasseribnr17inhighsucrosedietinducedobesemice AT soyoungjeong antiobesityeffectoflactobacillusgasseribnr17inhighsucrosedietinducedobesemice AT hanohpark antiobesityeffectoflactobacillusgasseribnr17inhighsucrosedietinducedobesemice
_version_	1718422658876440576

Anti-obesity effect of Lactobacillus gasseri BNR17 in high-sucrose diet-induced obese mice.

Ejemplares similares