Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy

Cancer is a global health and economic issue. The majority of anticancer therapies become ineffective due to frequent genomic turnover and chemoresistance. Furthermore, chemotherapy and radiation are non-specific, killing all rapidly dividing cells including healthy cells. In this review, we examine...

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Autor principal:	Reginald Halaby
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cancer lysosomes lysosomal membrane permeabilization apoptosis Medicine R
Acceso en línea:	https://doaj.org/article/3ef9d1a7153d492fb07d2e4eb78099dc
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spelling	oai:doaj.org-article:3ef9d1a7153d492fb07d2e4eb78099dc2021-11-25T18:19:21ZNatural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy10.3390/medicines81100692305-6320https://doaj.org/article/3ef9d1a7153d492fb07d2e4eb78099dc2021-11-01T00:00:00Zhttps://www.mdpi.com/2305-6320/8/11/69https://doaj.org/toc/2305-6320Cancer is a global health and economic issue. The majority of anticancer therapies become ineffective due to frequent genomic turnover and chemoresistance. Furthermore, chemotherapy and radiation are non-specific, killing all rapidly dividing cells including healthy cells. In this review, we examine the ability of some natural products to induce lysosomal-mediated cell death in neoplastic cells as a way to kill them more specifically than conventional therapies. This list is by no means exhaustive. We postulate mechanisms to explain lysosomal membrane permeabilization and its role in triggering cell death in cancer cells.Reginald HalabyMDPI AGarticlecancerlysosomeslysosomal membrane permeabilizationapoptosisMedicineRENMedicines, Vol 8, Iss 69, p 69 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer lysosomes lysosomal membrane permeabilization apoptosis Medicine R
spellingShingle	cancer lysosomes lysosomal membrane permeabilization apoptosis Medicine R Reginald Halaby Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy
description	Cancer is a global health and economic issue. The majority of anticancer therapies become ineffective due to frequent genomic turnover and chemoresistance. Furthermore, chemotherapy and radiation are non-specific, killing all rapidly dividing cells including healthy cells. In this review, we examine the ability of some natural products to induce lysosomal-mediated cell death in neoplastic cells as a way to kill them more specifically than conventional therapies. This list is by no means exhaustive. We postulate mechanisms to explain lysosomal membrane permeabilization and its role in triggering cell death in cancer cells.
format	article
author	Reginald Halaby
author_facet	Reginald Halaby
author_sort	Reginald Halaby
title	Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy
title_short	Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy
title_full	Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy
title_fullStr	Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy
title_full_unstemmed	Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy
title_sort	natural products induce lysosomal membrane permeabilization as an anticancer strategy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3ef9d1a7153d492fb07d2e4eb78099dc
work_keys_str_mv	AT reginaldhalaby naturalproductsinducelysosomalmembranepermeabilizationasananticancerstrategy
_version_	1718411314446991360

Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy

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