Epicardial adipose tissue volume and myocardial ischemia in asymptomatic people living with diabetes: a cross-sectional study
Abstract Background Epicardial adipose tissue (EAT) is considered a novel diagnostic marker for cardiometabolic disease. This study aimed to evaluate whether EAT volume was associated with stress-induced myocardial ischemia in asymptomatic people living with diabetes—independently of confounding fac...
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2021
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oai:doaj.org-article:3efded7ee80d417490296f86b23e68992021-11-28T12:14:12ZEpicardial adipose tissue volume and myocardial ischemia in asymptomatic people living with diabetes: a cross-sectional study10.1186/s12933-021-01420-51475-2840https://doaj.org/article/3efded7ee80d417490296f86b23e68992021-11-01T00:00:00Zhttps://doi.org/10.1186/s12933-021-01420-5https://doaj.org/toc/1475-2840Abstract Background Epicardial adipose tissue (EAT) is considered a novel diagnostic marker for cardiometabolic disease. This study aimed to evaluate whether EAT volume was associated with stress-induced myocardial ischemia in asymptomatic people living with diabetes—independently of confounding factors—and whether it could predict this condition. Methods We included asymptomatic patients with diabetes and no coronary history, who had undergone both a stress a myocardial scintigraphy to diagnose myocardial ischemia, and a computed tomography to measure their coronary artery calcium (CAC) score. EAT volume was retrospectively measured from computed tomography imaging. Determinants of EAT volume and asymptomatic myocardial ischemia were evaluated. Results The study population comprised 274 individuals, including 153 men. Mean (± standard deviation) age was 62 ± 9 years, and 243, 23 and 8 had type 2, type 1, or another type of diabetes, respectively. Mean body mass index was 30 ± 6 kg/m2, and mean EAT volume 96 ± 36 cm3. Myocardial ischemia was detected in 32 patients (11.7%). EAT volume was positively correlated with age, body mass index and triglyceridemia, but negatively correlated with HbA1c, HDL- and LDL-cholesterol levels. Furthermore, EAT volume was lower in people with retinopathy, but higher in men, in current smokers, in patients with nephropathy, those with a CAC score > 100 Agatston units, and finally in individuals with myocardial ischemia (110 ± 37 cm3 vs 94 ± 37 cm3 in those without myocardial ischemia, p < 0.05). The association between EAT volume and myocardial ischemia remained significant after adjustment for gender, diabetes duration, peripheral macrovascular disease and CAC score. We also found that area under the ROC curve analysis showed that EAT volume (AROC: 0.771 [95% confidence interval 0.683–0.858]) did not provide improved discrimination of myocardial ischemia over the following classic factors: gender, diabetes duration, peripheral macrovascular disease, retinopathy, nephropathy, smoking, atherogenic dyslipidemia, and CAC score (AROC 0.773 [0.683–0.862]). Conclusions EAT may play a role in coronary atherosclerosis and coronary circulation in patients with diabetes. However, considering EAT volume is not a better marker for discriminating the risk of asymptomatic myocardial ischemia than classic clinical data.Emmanuel CossonMinh Tuan NguyenImen RezganiNarimane BerkaneSara PintoHélène BihanSopio TatulashviliMalak TaherMeriem SalMichael SoussanPierre-Yves BrilletPaul ValensiBMCarticleComputed tomographyCoronary artery calcificationDiabetesEpicardial adipose tissueEpicardial fat tissueMyocardial ischemiaDiseases of the circulatory (Cardiovascular) systemRC666-701ENCardiovascular Diabetology, Vol 20, Iss 1, Pp 1-10 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Computed tomography Coronary artery calcification Diabetes Epicardial adipose tissue Epicardial fat tissue Myocardial ischemia Diseases of the circulatory (Cardiovascular) system RC666-701 |
| spellingShingle |
Computed tomography Coronary artery calcification Diabetes Epicardial adipose tissue Epicardial fat tissue Myocardial ischemia Diseases of the circulatory (Cardiovascular) system RC666-701 Emmanuel Cosson Minh Tuan Nguyen Imen Rezgani Narimane Berkane Sara Pinto Hélène Bihan Sopio Tatulashvili Malak Taher Meriem Sal Michael Soussan Pierre-Yves Brillet Paul Valensi Epicardial adipose tissue volume and myocardial ischemia in asymptomatic people living with diabetes: a cross-sectional study |
| description |
Abstract Background Epicardial adipose tissue (EAT) is considered a novel diagnostic marker for cardiometabolic disease. This study aimed to evaluate whether EAT volume was associated with stress-induced myocardial ischemia in asymptomatic people living with diabetes—independently of confounding factors—and whether it could predict this condition. Methods We included asymptomatic patients with diabetes and no coronary history, who had undergone both a stress a myocardial scintigraphy to diagnose myocardial ischemia, and a computed tomography to measure their coronary artery calcium (CAC) score. EAT volume was retrospectively measured from computed tomography imaging. Determinants of EAT volume and asymptomatic myocardial ischemia were evaluated. Results The study population comprised 274 individuals, including 153 men. Mean (± standard deviation) age was 62 ± 9 years, and 243, 23 and 8 had type 2, type 1, or another type of diabetes, respectively. Mean body mass index was 30 ± 6 kg/m2, and mean EAT volume 96 ± 36 cm3. Myocardial ischemia was detected in 32 patients (11.7%). EAT volume was positively correlated with age, body mass index and triglyceridemia, but negatively correlated with HbA1c, HDL- and LDL-cholesterol levels. Furthermore, EAT volume was lower in people with retinopathy, but higher in men, in current smokers, in patients with nephropathy, those with a CAC score > 100 Agatston units, and finally in individuals with myocardial ischemia (110 ± 37 cm3 vs 94 ± 37 cm3 in those without myocardial ischemia, p < 0.05). The association between EAT volume and myocardial ischemia remained significant after adjustment for gender, diabetes duration, peripheral macrovascular disease and CAC score. We also found that area under the ROC curve analysis showed that EAT volume (AROC: 0.771 [95% confidence interval 0.683–0.858]) did not provide improved discrimination of myocardial ischemia over the following classic factors: gender, diabetes duration, peripheral macrovascular disease, retinopathy, nephropathy, smoking, atherogenic dyslipidemia, and CAC score (AROC 0.773 [0.683–0.862]). Conclusions EAT may play a role in coronary atherosclerosis and coronary circulation in patients with diabetes. However, considering EAT volume is not a better marker for discriminating the risk of asymptomatic myocardial ischemia than classic clinical data. |
| format |
article |
| author |
Emmanuel Cosson Minh Tuan Nguyen Imen Rezgani Narimane Berkane Sara Pinto Hélène Bihan Sopio Tatulashvili Malak Taher Meriem Sal Michael Soussan Pierre-Yves Brillet Paul Valensi |
| author_facet |
Emmanuel Cosson Minh Tuan Nguyen Imen Rezgani Narimane Berkane Sara Pinto Hélène Bihan Sopio Tatulashvili Malak Taher Meriem Sal Michael Soussan Pierre-Yves Brillet Paul Valensi |
| author_sort |
Emmanuel Cosson |
| title |
Epicardial adipose tissue volume and myocardial ischemia in asymptomatic people living with diabetes: a cross-sectional study |
| title_short |
Epicardial adipose tissue volume and myocardial ischemia in asymptomatic people living with diabetes: a cross-sectional study |
| title_full |
Epicardial adipose tissue volume and myocardial ischemia in asymptomatic people living with diabetes: a cross-sectional study |
| title_fullStr |
Epicardial adipose tissue volume and myocardial ischemia in asymptomatic people living with diabetes: a cross-sectional study |
| title_full_unstemmed |
Epicardial adipose tissue volume and myocardial ischemia in asymptomatic people living with diabetes: a cross-sectional study |
| title_sort |
epicardial adipose tissue volume and myocardial ischemia in asymptomatic people living with diabetes: a cross-sectional study |
| publisher |
BMC |
| publishDate |
2021 |
| url |
https://doaj.org/article/3efded7ee80d417490296f86b23e6899 |
| work_keys_str_mv |
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