Toxicological and Anti-Rheumatic Potential of Trachyspermum ammi Derived Biogenic Selenium Nanoparticles in Arthritic Balb/c Mice

Naila Qamar, Peter John, Attya Bhatti Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology (NUST), Islamabad, PakistanCorrespondence: Peter JohnDepartment of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Bio...

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Autores principales:	Qamar N, John P, Bhatti A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	rheumatoid arthritis collagen-induced arthritis selenium nanoparticles trachyspermum ammi Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3effe8a1cf5e400687d7bd399fef2777
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spelling	oai:doaj.org-article:3effe8a1cf5e400687d7bd399fef27772021-12-02T10:04:42ZToxicological and Anti-Rheumatic Potential of Trachyspermum ammi Derived Biogenic Selenium Nanoparticles in Arthritic Balb/c Mice1178-2013https://doaj.org/article/3effe8a1cf5e400687d7bd399fef27772020-05-01T00:00:00Zhttps://www.dovepress.com/toxicological-and-anti-rheumatic-potential-of-trachyspermum-ammi-deriv-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Naila Qamar, Peter John, Attya Bhatti Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology (NUST), Islamabad, PakistanCorrespondence: Peter JohnDepartment of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology (NUST), Sector H-12, Islamabad, PakistanTel +92 51-90856151Email pjohn72@hotmail.comPurpose: The existing treatment modalities for rheumatoid arthritis are less effective and safe, therefore it is essential to develop new treatments that particularly target the inflamed joints with decreased off-target side-effects. The current study proposes a nanoparticle-based therapeutic approach to target the anti-oxidant defense system of arthritic Balb/c mice.Methods: Biogenic selenium nanoparticles (SeNPs) were synthesized by using Trachyspermum ammi seed extract and were evaluated for their toxicological, as well as their therapeutic potential in collagen-induced arthritic mice.Results: The tested doses of SeNPs had no significant toxic effects on liver, kidney, spleen, and serum biochemical parameters in comparison to healthy mice. The SeNPs treatment reduced the disease severity, as demonstrated by decreased paw edema along with reduced lymphocytic cellular infiltration in the histopathological findings. SeNPs also revealed dose-independent improvement in the redox state of inflamed synovium by significantly improving the activity of antioxidant enzymes in comparison to the arthritic controls.Conclusion: It is therefore concluded that nano-selenium in combination with TAE extract showed enhanced therapeutic efficacy as compared to their individual effects.Keywords: rheumatoid arthritis, collagen-induced arthritis, selenium nanoparticles, Trachyspermum ammi  Qamar NJohn PBhatti ADove Medical Pressarticlerheumatoid arthritiscollagen-induced arthritisselenium nanoparticlestrachyspermum ammiMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 3497-3509 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	rheumatoid arthritis collagen-induced arthritis selenium nanoparticles trachyspermum ammi Medicine (General) R5-920
spellingShingle	rheumatoid arthritis collagen-induced arthritis selenium nanoparticles trachyspermum ammi Medicine (General) R5-920 Qamar N John P Bhatti A Toxicological and Anti-Rheumatic Potential of Trachyspermum ammi Derived Biogenic Selenium Nanoparticles in Arthritic Balb/c Mice
description	Naila Qamar, Peter John, Attya Bhatti Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology (NUST), Islamabad, PakistanCorrespondence: Peter JohnDepartment of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology (NUST), Sector H-12, Islamabad, PakistanTel +92 51-90856151Email pjohn72@hotmail.comPurpose: The existing treatment modalities for rheumatoid arthritis are less effective and safe, therefore it is essential to develop new treatments that particularly target the inflamed joints with decreased off-target side-effects. The current study proposes a nanoparticle-based therapeutic approach to target the anti-oxidant defense system of arthritic Balb/c mice.Methods: Biogenic selenium nanoparticles (SeNPs) were synthesized by using Trachyspermum ammi seed extract and were evaluated for their toxicological, as well as their therapeutic potential in collagen-induced arthritic mice.Results: The tested doses of SeNPs had no significant toxic effects on liver, kidney, spleen, and serum biochemical parameters in comparison to healthy mice. The SeNPs treatment reduced the disease severity, as demonstrated by decreased paw edema along with reduced lymphocytic cellular infiltration in the histopathological findings. SeNPs also revealed dose-independent improvement in the redox state of inflamed synovium by significantly improving the activity of antioxidant enzymes in comparison to the arthritic controls.Conclusion: It is therefore concluded that nano-selenium in combination with TAE extract showed enhanced therapeutic efficacy as compared to their individual effects.Keywords: rheumatoid arthritis, collagen-induced arthritis, selenium nanoparticles, Trachyspermum ammi
format	article
author	Qamar N John P Bhatti A
author_facet	Qamar N John P Bhatti A
author_sort	Qamar N
title	Toxicological and Anti-Rheumatic Potential of Trachyspermum ammi Derived Biogenic Selenium Nanoparticles in Arthritic Balb/c Mice
title_short	Toxicological and Anti-Rheumatic Potential of Trachyspermum ammi Derived Biogenic Selenium Nanoparticles in Arthritic Balb/c Mice
title_full	Toxicological and Anti-Rheumatic Potential of Trachyspermum ammi Derived Biogenic Selenium Nanoparticles in Arthritic Balb/c Mice
title_fullStr	Toxicological and Anti-Rheumatic Potential of Trachyspermum ammi Derived Biogenic Selenium Nanoparticles in Arthritic Balb/c Mice
title_full_unstemmed	Toxicological and Anti-Rheumatic Potential of Trachyspermum ammi Derived Biogenic Selenium Nanoparticles in Arthritic Balb/c Mice
title_sort	toxicological and anti-rheumatic potential of trachyspermum ammi derived biogenic selenium nanoparticles in arthritic balb/c mice
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/3effe8a1cf5e400687d7bd399fef2777
work_keys_str_mv	AT qamarn toxicologicalandantirheumaticpotentialoftrachyspermumammiderivedbiogenicseleniumnanoparticlesinarthriticbalbcmice AT johnp toxicologicalandantirheumaticpotentialoftrachyspermumammiderivedbiogenicseleniumnanoparticlesinarthriticbalbcmice AT bhattia toxicologicalandantirheumaticpotentialoftrachyspermumammiderivedbiogenicseleniumnanoparticlesinarthriticbalbcmice
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Toxicological and Anti-Rheumatic Potential of Trachyspermum ammi Derived Biogenic Selenium Nanoparticles in Arthritic Balb/c Mice

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