The relationship between retinal nerve fibre layer thickness profiles and CorvisST tonometry measured biomechanical properties in young healthy subjects

Abstract We previously reported that a shallow circumpapillary retinal nerve fiber layer (cpRNFL) peak angle as measured by optical coherence tomography (OCT) suggests the temporal retina is stretched around the optic disc from the papillo-macular bundle (Yamashita T et al. Investigative Ophthalmol...

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Autores principales:	Masato Matsuura, Hiroshi Murata, Shunsuke Nakakura, Yoshitaka Nakao, Takehiro Yamashita, Kazunori Hirasawa, Yuri Fujino, Yoshiaki Kiuchi, Ryo Asaoka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3f0175eb1f304b9ab973e53375281735
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spelling	oai:doaj.org-article:3f0175eb1f304b9ab973e533752817352021-12-02T12:32:01ZThe relationship between retinal nerve fibre layer thickness profiles and CorvisST tonometry measured biomechanical properties in young healthy subjects10.1038/s41598-017-00345-y2045-2322https://doaj.org/article/3f0175eb1f304b9ab973e533752817352017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00345-yhttps://doaj.org/toc/2045-2322Abstract We previously reported that a shallow circumpapillary retinal nerve fiber layer (cpRNFL) peak angle as measured by optical coherence tomography (OCT) suggests the temporal retina is stretched around the optic disc from the papillo-macular bundle (Yamashita T et al. Investigative Ophthalmol Vis Sci 2013). The purpose of the current study was to investigate the relationship between CorvisST tonometry (CST) corneal measurements, axial length (AL) and the change in OCT-measured cpRNFL peak angle, in young healthy subjects. OCT and CST measurements were carried out in 97 eyes of 97 young healthy volunteers. The relationship between cpRNFL peak angle and 12 CST parameters, adjusted for AL, was investigated using linear modelling. The mean ± standard deviation cpRNFL peak angle of the 97 healthy volunteers was 130.6 ± 25.4 (range: 77.8 to 207.0) degrees. The optimal linear model to explain cpRNFL peak angle (chosen from 216 different models) included three CST variables related to the speed and size of energy absorption (namely, A1 time, A1 length and A2 time), in addition to AL. In eyes with longer AL and shorter energy absorption in CST measurement, temporal retina is stretched around the optic disc from the papillo-macular bundle, as suggested by a shallow cpRNFL peak angle.Masato MatsuuraHiroshi MurataShunsuke NakakuraYoshitaka NakaoTakehiro YamashitaKazunori HirasawaYuri FujinoYoshiaki KiuchiRyo AsaokaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masato Matsuura Hiroshi Murata Shunsuke Nakakura Yoshitaka Nakao Takehiro Yamashita Kazunori Hirasawa Yuri Fujino Yoshiaki Kiuchi Ryo Asaoka The relationship between retinal nerve fibre layer thickness profiles and CorvisST tonometry measured biomechanical properties in young healthy subjects
description	Abstract We previously reported that a shallow circumpapillary retinal nerve fiber layer (cpRNFL) peak angle as measured by optical coherence tomography (OCT) suggests the temporal retina is stretched around the optic disc from the papillo-macular bundle (Yamashita T et al. Investigative Ophthalmol Vis Sci 2013). The purpose of the current study was to investigate the relationship between CorvisST tonometry (CST) corneal measurements, axial length (AL) and the change in OCT-measured cpRNFL peak angle, in young healthy subjects. OCT and CST measurements were carried out in 97 eyes of 97 young healthy volunteers. The relationship between cpRNFL peak angle and 12 CST parameters, adjusted for AL, was investigated using linear modelling. The mean ± standard deviation cpRNFL peak angle of the 97 healthy volunteers was 130.6 ± 25.4 (range: 77.8 to 207.0) degrees. The optimal linear model to explain cpRNFL peak angle (chosen from 216 different models) included three CST variables related to the speed and size of energy absorption (namely, A1 time, A1 length and A2 time), in addition to AL. In eyes with longer AL and shorter energy absorption in CST measurement, temporal retina is stretched around the optic disc from the papillo-macular bundle, as suggested by a shallow cpRNFL peak angle.
format	article
author	Masato Matsuura Hiroshi Murata Shunsuke Nakakura Yoshitaka Nakao Takehiro Yamashita Kazunori Hirasawa Yuri Fujino Yoshiaki Kiuchi Ryo Asaoka
author_facet	Masato Matsuura Hiroshi Murata Shunsuke Nakakura Yoshitaka Nakao Takehiro Yamashita Kazunori Hirasawa Yuri Fujino Yoshiaki Kiuchi Ryo Asaoka
author_sort	Masato Matsuura
title	The relationship between retinal nerve fibre layer thickness profiles and CorvisST tonometry measured biomechanical properties in young healthy subjects
title_short	The relationship between retinal nerve fibre layer thickness profiles and CorvisST tonometry measured biomechanical properties in young healthy subjects
title_full	The relationship between retinal nerve fibre layer thickness profiles and CorvisST tonometry measured biomechanical properties in young healthy subjects
title_fullStr	The relationship between retinal nerve fibre layer thickness profiles and CorvisST tonometry measured biomechanical properties in young healthy subjects
title_full_unstemmed	The relationship between retinal nerve fibre layer thickness profiles and CorvisST tonometry measured biomechanical properties in young healthy subjects
title_sort	relationship between retinal nerve fibre layer thickness profiles and corvisst tonometry measured biomechanical properties in young healthy subjects
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3f0175eb1f304b9ab973e53375281735
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The relationship between retinal nerve fibre layer thickness profiles and CorvisST tonometry measured biomechanical properties in young healthy subjects

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