Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo

K+ plays an important role in physiology and disease, but the lack of high specificity K+ sensors limits our understanding of its spatiotemporal dynamics. Here the authors develop genetically-encoded FRET-based probes able to quantify K+ concentration in body fluids, cells and specific organelles.

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Autores principales:	Helmut Bischof, Markus Rehberg, Sarah Stryeck, Katharina Artinger, Emrah Eroglu, Markus Waldeck-Weiermair, Benjamin Gottschalk, Rene Rost, Andras T. Deak, Tobias Niedrist, Nemanja Vujic, Hanna Lindermuth, Ruth Prassl, Brigitte Pelzmann, Klaus Groschner, Dagmar Kratky, Kathrin Eller, Alexander R. Rosenkranz, Tobias Madl, Nikolaus Plesnila, Wolfgang F. Graier, Roland Malli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3f0690a062df4c16ae8ab8e09d354078
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spelling	oai:doaj.org-article:3f0690a062df4c16ae8ab8e09d3540782021-12-02T14:42:44ZNovel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo10.1038/s41467-017-01615-z2041-1723https://doaj.org/article/3f0690a062df4c16ae8ab8e09d3540782017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01615-zhttps://doaj.org/toc/2041-1723K+ plays an important role in physiology and disease, but the lack of high specificity K+ sensors limits our understanding of its spatiotemporal dynamics. Here the authors develop genetically-encoded FRET-based probes able to quantify K+ concentration in body fluids, cells and specific organelles.Helmut BischofMarkus RehbergSarah StryeckKatharina ArtingerEmrah ErogluMarkus Waldeck-WeiermairBenjamin GottschalkRene RostAndras T. DeakTobias NiedristNemanja VujicHanna LindermuthRuth PrasslBrigitte PelzmannKlaus GroschnerDagmar KratkyKathrin EllerAlexander R. RosenkranzTobias MadlNikolaus PlesnilaWolfgang F. GraierRoland MalliNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Helmut Bischof Markus Rehberg Sarah Stryeck Katharina Artinger Emrah Eroglu Markus Waldeck-Weiermair Benjamin Gottschalk Rene Rost Andras T. Deak Tobias Niedrist Nemanja Vujic Hanna Lindermuth Ruth Prassl Brigitte Pelzmann Klaus Groschner Dagmar Kratky Kathrin Eller Alexander R. Rosenkranz Tobias Madl Nikolaus Plesnila Wolfgang F. Graier Roland Malli Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo
description	K+ plays an important role in physiology and disease, but the lack of high specificity K+ sensors limits our understanding of its spatiotemporal dynamics. Here the authors develop genetically-encoded FRET-based probes able to quantify K+ concentration in body fluids, cells and specific organelles.
format	article
author	Helmut Bischof Markus Rehberg Sarah Stryeck Katharina Artinger Emrah Eroglu Markus Waldeck-Weiermair Benjamin Gottschalk Rene Rost Andras T. Deak Tobias Niedrist Nemanja Vujic Hanna Lindermuth Ruth Prassl Brigitte Pelzmann Klaus Groschner Dagmar Kratky Kathrin Eller Alexander R. Rosenkranz Tobias Madl Nikolaus Plesnila Wolfgang F. Graier Roland Malli
author_facet	Helmut Bischof Markus Rehberg Sarah Stryeck Katharina Artinger Emrah Eroglu Markus Waldeck-Weiermair Benjamin Gottschalk Rene Rost Andras T. Deak Tobias Niedrist Nemanja Vujic Hanna Lindermuth Ruth Prassl Brigitte Pelzmann Klaus Groschner Dagmar Kratky Kathrin Eller Alexander R. Rosenkranz Tobias Madl Nikolaus Plesnila Wolfgang F. Graier Roland Malli
author_sort	Helmut Bischof
title	Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo
title_short	Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo
title_full	Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo
title_fullStr	Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo
title_full_unstemmed	Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo
title_sort	novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3f0690a062df4c16ae8ab8e09d354078
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Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo

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