Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme

Twister-sister is a self-cleaving ribozyme. Here, the authors report the 2.0 Å crystal structure of the four-way junctional twister-sister ribozyme in the pre-catalytic state and discuss mechanistic implications based on their mutagenesis experiments and comparisons with other ribozyme structures....

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Autores principales:	Luqian Zheng, Elisabeth Mairhofer, Marianna Teplova, Ye Zhang, Jinbiao Ma, Dinshaw J. Patel, Ronald Micura, Aiming Ren
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3f0c978cdb61435a9e3fd422ad02ce2f
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spelling	oai:doaj.org-article:3f0c978cdb61435a9e3fd422ad02ce2f2021-12-02T14:42:19ZStructure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme10.1038/s41467-017-01276-y2041-1723https://doaj.org/article/3f0c978cdb61435a9e3fd422ad02ce2f2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01276-yhttps://doaj.org/toc/2041-1723Twister-sister is a self-cleaving ribozyme. Here, the authors report the 2.0 Å crystal structure of the four-way junctional twister-sister ribozyme in the pre-catalytic state and discuss mechanistic implications based on their mutagenesis experiments and comparisons with other ribozyme structures.Luqian ZhengElisabeth MairhoferMarianna TeplovaYe ZhangJinbiao MaDinshaw J. PatelRonald MicuraAiming RenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luqian Zheng Elisabeth Mairhofer Marianna Teplova Ye Zhang Jinbiao Ma Dinshaw J. Patel Ronald Micura Aiming Ren Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme
description	Twister-sister is a self-cleaving ribozyme. Here, the authors report the 2.0 Å crystal structure of the four-way junctional twister-sister ribozyme in the pre-catalytic state and discuss mechanistic implications based on their mutagenesis experiments and comparisons with other ribozyme structures.
format	article
author	Luqian Zheng Elisabeth Mairhofer Marianna Teplova Ye Zhang Jinbiao Ma Dinshaw J. Patel Ronald Micura Aiming Ren
author_facet	Luqian Zheng Elisabeth Mairhofer Marianna Teplova Ye Zhang Jinbiao Ma Dinshaw J. Patel Ronald Micura Aiming Ren
author_sort	Luqian Zheng
title	Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme
title_short	Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme
title_full	Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme
title_fullStr	Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme
title_full_unstemmed	Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme
title_sort	structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3f0c978cdb61435a9e3fd422ad02ce2f
work_keys_str_mv	AT luqianzheng structurebasedinsightsintoselfcleavagebyafourwayjunctionaltwistersisterribozyme AT elisabethmairhofer structurebasedinsightsintoselfcleavagebyafourwayjunctionaltwistersisterribozyme AT mariannateplova structurebasedinsightsintoselfcleavagebyafourwayjunctionaltwistersisterribozyme AT yezhang structurebasedinsightsintoselfcleavagebyafourwayjunctionaltwistersisterribozyme AT jinbiaoma structurebasedinsightsintoselfcleavagebyafourwayjunctionaltwistersisterribozyme AT dinshawjpatel structurebasedinsightsintoselfcleavagebyafourwayjunctionaltwistersisterribozyme AT ronaldmicura structurebasedinsightsintoselfcleavagebyafourwayjunctionaltwistersisterribozyme AT aimingren structurebasedinsightsintoselfcleavagebyafourwayjunctionaltwistersisterribozyme
_version_	1718389744746889216

Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme

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