Macular vessel density, branching complexity and foveal avascular zone size in normal tension glaucoma

Abstract The aim of this study was to investigate the relationship between glaucoma severity and perifoveal vessel density (pfVD), branching complexity, and foveal avascular zone (FAZ) size in normal tension glaucoma (NTG). 31 patients with NTG washed out of glaucoma medications were subjected to te...

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Autores principales:	Kelvin K. W. Cheng, Beatrice L. Tan, Lyndsay Brown, Calum Gray, Eleonora Bianchi, Baljean Dhillon, Tom MacGillivray, Andrew J. Tatham
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3f1470f47340480faa7524a152f66e27
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spelling	oai:doaj.org-article:3f1470f47340480faa7524a152f66e272021-12-02T14:01:24ZMacular vessel density, branching complexity and foveal avascular zone size in normal tension glaucoma10.1038/s41598-020-80080-z2045-2322https://doaj.org/article/3f1470f47340480faa7524a152f66e272021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80080-zhttps://doaj.org/toc/2045-2322Abstract The aim of this study was to investigate the relationship between glaucoma severity and perifoveal vessel density (pfVD), branching complexity, and foveal avascular zone (FAZ) size in normal tension glaucoma (NTG). 31 patients with NTG washed out of glaucoma medications were subjected to tests including; intraocular pressure measurement; standard automated perimetry; optical coherence tomography (OCT) measurement of macular ganglion cell complex (mGCC), inner macular thickness (IMT) and circumpapillary retinal nerve fibre layer (cpRNFL); and OCT angiography measurement of pfVD, FAZ perimeter and multispectral fractal dimensions (MSFD). Eyes with more severe glaucoma had significantly thinner mGCC and cpRNFL and lower pfVD. MD decreased by 0.4 dB (95% CI 0.1 to 0.6 dB, P = 0.007) for every 1% decrease in pfVD. Lower MSFD was observed in eyes with lower pfVD and in patients with systemic hypertension. Multivariable analysis, accounting for age and OCTA quality, found lower pfVD remained significantly associated with thinner IMT, thinner mGCC and worse MD but not with MSFD. pfVD was reduced in NTG and was diminished in eyes with worse MD. Macular vessel branching complexity was not related to severity of visual field loss but was lower in patients with systemic hypertension.Kelvin K. W. ChengBeatrice L. TanLyndsay BrownCalum GrayEleonora BianchiBaljean DhillonTom MacGillivrayAndrew J. TathamNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kelvin K. W. Cheng Beatrice L. Tan Lyndsay Brown Calum Gray Eleonora Bianchi Baljean Dhillon Tom MacGillivray Andrew J. Tatham Macular vessel density, branching complexity and foveal avascular zone size in normal tension glaucoma
description	Abstract The aim of this study was to investigate the relationship between glaucoma severity and perifoveal vessel density (pfVD), branching complexity, and foveal avascular zone (FAZ) size in normal tension glaucoma (NTG). 31 patients with NTG washed out of glaucoma medications were subjected to tests including; intraocular pressure measurement; standard automated perimetry; optical coherence tomography (OCT) measurement of macular ganglion cell complex (mGCC), inner macular thickness (IMT) and circumpapillary retinal nerve fibre layer (cpRNFL); and OCT angiography measurement of pfVD, FAZ perimeter and multispectral fractal dimensions (MSFD). Eyes with more severe glaucoma had significantly thinner mGCC and cpRNFL and lower pfVD. MD decreased by 0.4 dB (95% CI 0.1 to 0.6 dB, P = 0.007) for every 1% decrease in pfVD. Lower MSFD was observed in eyes with lower pfVD and in patients with systemic hypertension. Multivariable analysis, accounting for age and OCTA quality, found lower pfVD remained significantly associated with thinner IMT, thinner mGCC and worse MD but not with MSFD. pfVD was reduced in NTG and was diminished in eyes with worse MD. Macular vessel branching complexity was not related to severity of visual field loss but was lower in patients with systemic hypertension.
format	article
author	Kelvin K. W. Cheng Beatrice L. Tan Lyndsay Brown Calum Gray Eleonora Bianchi Baljean Dhillon Tom MacGillivray Andrew J. Tatham
author_facet	Kelvin K. W. Cheng Beatrice L. Tan Lyndsay Brown Calum Gray Eleonora Bianchi Baljean Dhillon Tom MacGillivray Andrew J. Tatham
author_sort	Kelvin K. W. Cheng
title	Macular vessel density, branching complexity and foveal avascular zone size in normal tension glaucoma
title_short	Macular vessel density, branching complexity and foveal avascular zone size in normal tension glaucoma
title_full	Macular vessel density, branching complexity and foveal avascular zone size in normal tension glaucoma
title_fullStr	Macular vessel density, branching complexity and foveal avascular zone size in normal tension glaucoma
title_full_unstemmed	Macular vessel density, branching complexity and foveal avascular zone size in normal tension glaucoma
title_sort	macular vessel density, branching complexity and foveal avascular zone size in normal tension glaucoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3f1470f47340480faa7524a152f66e27
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Macular vessel density, branching complexity and foveal avascular zone size in normal tension glaucoma

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