Common Brain Structure Findings Across Children with Varied Reading Disability Profiles

Abstract Dyslexia is a developmental disorder in reading that exhibits varied patterns of expression across children. Here we examined the degree to which different kinds of reading disabilities (defined as profiles or patterns of reading problems) contribute to brain morphology results in Jacobian...

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Autores principales:	Mark A. Eckert, Kenneth I. Vaden, Amanda B. Maxwell, Stephanie L. Cute, Mulugeta Gebregziabher, Virginia W. Berninger, Dyslexia Data Consortium
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3f14c3a24f2148f39102124d62148c55
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spelling	oai:doaj.org-article:3f14c3a24f2148f39102124d62148c552021-12-02T16:06:32ZCommon Brain Structure Findings Across Children with Varied Reading Disability Profiles10.1038/s41598-017-05691-52045-2322https://doaj.org/article/3f14c3a24f2148f39102124d62148c552017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05691-5https://doaj.org/toc/2045-2322Abstract Dyslexia is a developmental disorder in reading that exhibits varied patterns of expression across children. Here we examined the degree to which different kinds of reading disabilities (defined as profiles or patterns of reading problems) contribute to brain morphology results in Jacobian determinant images that represent local brain shape and volume. A matched-pair brain morphometry approach was used to control for confounding from brain size and research site effects in this retrospective multi-site study of 134 children from eight different research sites. Parietal operculum, corona radiata, and internal capsule differences between cases and controls were consistently observed across children with evidence of classic dyslexia, specific comprehension deficit, and language learning disability. Thus, there can be common brain morphology findings across children with quite varied reading disability profiles that we hypothesize compound the developmental difficulties of children with unique reading disability profiles and reasons for their reading disability.Mark A. EckertKenneth I. VadenAmanda B. MaxwellStephanie L. CuteMulugeta GebregziabherVirginia W. BerningerDyslexia Data ConsortiumNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mark A. Eckert Kenneth I. Vaden Amanda B. Maxwell Stephanie L. Cute Mulugeta Gebregziabher Virginia W. Berninger Dyslexia Data Consortium Common Brain Structure Findings Across Children with Varied Reading Disability Profiles
description	Abstract Dyslexia is a developmental disorder in reading that exhibits varied patterns of expression across children. Here we examined the degree to which different kinds of reading disabilities (defined as profiles or patterns of reading problems) contribute to brain morphology results in Jacobian determinant images that represent local brain shape and volume. A matched-pair brain morphometry approach was used to control for confounding from brain size and research site effects in this retrospective multi-site study of 134 children from eight different research sites. Parietal operculum, corona radiata, and internal capsule differences between cases and controls were consistently observed across children with evidence of classic dyslexia, specific comprehension deficit, and language learning disability. Thus, there can be common brain morphology findings across children with quite varied reading disability profiles that we hypothesize compound the developmental difficulties of children with unique reading disability profiles and reasons for their reading disability.
format	article
author	Mark A. Eckert Kenneth I. Vaden Amanda B. Maxwell Stephanie L. Cute Mulugeta Gebregziabher Virginia W. Berninger Dyslexia Data Consortium
author_facet	Mark A. Eckert Kenneth I. Vaden Amanda B. Maxwell Stephanie L. Cute Mulugeta Gebregziabher Virginia W. Berninger Dyslexia Data Consortium
author_sort	Mark A. Eckert
title	Common Brain Structure Findings Across Children with Varied Reading Disability Profiles
title_short	Common Brain Structure Findings Across Children with Varied Reading Disability Profiles
title_full	Common Brain Structure Findings Across Children with Varied Reading Disability Profiles
title_fullStr	Common Brain Structure Findings Across Children with Varied Reading Disability Profiles
title_full_unstemmed	Common Brain Structure Findings Across Children with Varied Reading Disability Profiles
title_sort	common brain structure findings across children with varied reading disability profiles
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3f14c3a24f2148f39102124d62148c55
work_keys_str_mv	AT markaeckert commonbrainstructurefindingsacrosschildrenwithvariedreadingdisabilityprofiles AT kennethivaden commonbrainstructurefindingsacrosschildrenwithvariedreadingdisabilityprofiles AT amandabmaxwell commonbrainstructurefindingsacrosschildrenwithvariedreadingdisabilityprofiles AT stephanielcute commonbrainstructurefindingsacrosschildrenwithvariedreadingdisabilityprofiles AT mulugetagebregziabher commonbrainstructurefindingsacrosschildrenwithvariedreadingdisabilityprofiles AT virginiawberninger commonbrainstructurefindingsacrosschildrenwithvariedreadingdisabilityprofiles AT dyslexiadataconsortium commonbrainstructurefindingsacrosschildrenwithvariedreadingdisabilityprofiles
_version_	1718384956399419392

Common Brain Structure Findings Across Children with Varied Reading Disability Profiles

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