Collagen fiber orientation disorder from H&E images is prognostic for early stage breast cancer: clinical trial validation

Abstract Collagen fiber organization has been found to be implicated in breast cancer prognosis. In this study, we evaluated whether computerized features of Collagen Fiber Orientation Disorder in Tumor-associated Stroma (CFOD-TS) on Hematoxylin & Eosin (H&E) slide images were prognostic of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Haojia Li, Kaustav Bera, Paula Toro, PingFu Fu, Zelin Zhang, Cheng Lu, Michael Feldman, Shridar Ganesan, Lori J. Goldstein, Nancy E. Davidson, Akisha Glasgow, Aparna Harbhajanka, Hannah Gilmore, Anant Madabhushi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/3f1567d71b5f43f1be83cf5666df32a7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3f1567d71b5f43f1be83cf5666df32a7
record_format	dspace
spelling	oai:doaj.org-article:3f1567d71b5f43f1be83cf5666df32a72021-12-02T18:49:27ZCollagen fiber orientation disorder from H&E images is prognostic for early stage breast cancer: clinical trial validation10.1038/s41523-021-00310-z2374-4677https://doaj.org/article/3f1567d71b5f43f1be83cf5666df32a72021-08-01T00:00:00Zhttps://doi.org/10.1038/s41523-021-00310-zhttps://doaj.org/toc/2374-4677Abstract Collagen fiber organization has been found to be implicated in breast cancer prognosis. In this study, we evaluated whether computerized features of Collagen Fiber Orientation Disorder in Tumor-associated Stroma (CFOD-TS) on Hematoxylin & Eosin (H&E) slide images were prognostic of Disease Free Survival (DFS) in early stage Estrogen Receptor Positive (ER+) Invasive Breast Cancers (IBC). A Cox regression model named MCFOD-TS, was constructed using cohort St (N = 78) to predict DFS based on CFOD-TS features. The prognostic performance of MCFOD-TS was validated on cohort Sv (N = 219), a prospective clinical trial dataset (ECOG 2197). MCFOD-TS was prognostic of DFS in both St and Sv, independent of clinicopathological variables. Additionally, the molecular pathways regarding cell cycle regulation were identified as being significantly associated with MCFOD-TS derived risk scores. Our results also found that collagen fiber organization was more ordered in patients with short DFS. Our study provided a H&E image-based pipeline to derive a potential prognostic biomarker for early stage ER+ IBC without the need of special collagen staining or advanced microscopy techniques.Haojia LiKaustav BeraPaula ToroPingFu FuZelin ZhangCheng LuMichael FeldmanShridar GanesanLori J. GoldsteinNancy E. DavidsonAkisha GlasgowAparna HarbhajankaHannah GilmoreAnant MadabhushiNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 7, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Haojia Li Kaustav Bera Paula Toro PingFu Fu Zelin Zhang Cheng Lu Michael Feldman Shridar Ganesan Lori J. Goldstein Nancy E. Davidson Akisha Glasgow Aparna Harbhajanka Hannah Gilmore Anant Madabhushi Collagen fiber orientation disorder from H&E images is prognostic for early stage breast cancer: clinical trial validation
description	Abstract Collagen fiber organization has been found to be implicated in breast cancer prognosis. In this study, we evaluated whether computerized features of Collagen Fiber Orientation Disorder in Tumor-associated Stroma (CFOD-TS) on Hematoxylin & Eosin (H&E) slide images were prognostic of Disease Free Survival (DFS) in early stage Estrogen Receptor Positive (ER+) Invasive Breast Cancers (IBC). A Cox regression model named MCFOD-TS, was constructed using cohort St (N = 78) to predict DFS based on CFOD-TS features. The prognostic performance of MCFOD-TS was validated on cohort Sv (N = 219), a prospective clinical trial dataset (ECOG 2197). MCFOD-TS was prognostic of DFS in both St and Sv, independent of clinicopathological variables. Additionally, the molecular pathways regarding cell cycle regulation were identified as being significantly associated with MCFOD-TS derived risk scores. Our results also found that collagen fiber organization was more ordered in patients with short DFS. Our study provided a H&E image-based pipeline to derive a potential prognostic biomarker for early stage ER+ IBC without the need of special collagen staining or advanced microscopy techniques.
format	article
author	Haojia Li Kaustav Bera Paula Toro PingFu Fu Zelin Zhang Cheng Lu Michael Feldman Shridar Ganesan Lori J. Goldstein Nancy E. Davidson Akisha Glasgow Aparna Harbhajanka Hannah Gilmore Anant Madabhushi
author_facet	Haojia Li Kaustav Bera Paula Toro PingFu Fu Zelin Zhang Cheng Lu Michael Feldman Shridar Ganesan Lori J. Goldstein Nancy E. Davidson Akisha Glasgow Aparna Harbhajanka Hannah Gilmore Anant Madabhushi
author_sort	Haojia Li
title	Collagen fiber orientation disorder from H&E images is prognostic for early stage breast cancer: clinical trial validation
title_short	Collagen fiber orientation disorder from H&E images is prognostic for early stage breast cancer: clinical trial validation
title_full	Collagen fiber orientation disorder from H&E images is prognostic for early stage breast cancer: clinical trial validation
title_fullStr	Collagen fiber orientation disorder from H&E images is prognostic for early stage breast cancer: clinical trial validation
title_full_unstemmed	Collagen fiber orientation disorder from H&E images is prognostic for early stage breast cancer: clinical trial validation
title_sort	collagen fiber orientation disorder from h&e images is prognostic for early stage breast cancer: clinical trial validation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3f1567d71b5f43f1be83cf5666df32a7
work_keys_str_mv	AT haojiali collagenfiberorientationdisorderfromheimagesisprognosticforearlystagebreastcancerclinicaltrialvalidation AT kaustavbera collagenfiberorientationdisorderfromheimagesisprognosticforearlystagebreastcancerclinicaltrialvalidation AT paulatoro collagenfiberorientationdisorderfromheimagesisprognosticforearlystagebreastcancerclinicaltrialvalidation AT pingfufu collagenfiberorientationdisorderfromheimagesisprognosticforearlystagebreastcancerclinicaltrialvalidation AT zelinzhang collagenfiberorientationdisorderfromheimagesisprognosticforearlystagebreastcancerclinicaltrialvalidation AT chenglu collagenfiberorientationdisorderfromheimagesisprognosticforearlystagebreastcancerclinicaltrialvalidation AT michaelfeldman collagenfiberorientationdisorderfromheimagesisprognosticforearlystagebreastcancerclinicaltrialvalidation AT shridarganesan collagenfiberorientationdisorderfromheimagesisprognosticforearlystagebreastcancerclinicaltrialvalidation AT lorijgoldstein collagenfiberorientationdisorderfromheimagesisprognosticforearlystagebreastcancerclinicaltrialvalidation AT nancyedavidson collagenfiberorientationdisorderfromheimagesisprognosticforearlystagebreastcancerclinicaltrialvalidation AT akishaglasgow collagenfiberorientationdisorderfromheimagesisprognosticforearlystagebreastcancerclinicaltrialvalidation AT aparnaharbhajanka collagenfiberorientationdisorderfromheimagesisprognosticforearlystagebreastcancerclinicaltrialvalidation AT hannahgilmore collagenfiberorientationdisorderfromheimagesisprognosticforearlystagebreastcancerclinicaltrialvalidation AT anantmadabhushi collagenfiberorientationdisorderfromheimagesisprognosticforearlystagebreastcancerclinicaltrialvalidation
_version_	1718377556471709696

Collagen fiber orientation disorder from H&E images is prognostic for early stage breast cancer: clinical trial validation

Ejemplares similares