Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates

The tumor suppressor p53 is a master regulator of cellular stress response pathways, including cell cycle arrest and apoptosis. Here, the authors identify molecular mechanisms of p53 binding to high- and low-affinity p53 response elements in the genome, linked to cell cycle arrest and pro-apoptotic...

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Autores principales:	Marina Farkas, Hideharu Hashimoto, Yingtao Bi, Ramana V. Davuluri, Lois Resnick-Silverman, James J. Manfredi, Erik W. Debler, Steven B. McMahon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3f1e9178c9564dfeb7beebe3db18db73
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spelling	oai:doaj.org-article:3f1e9178c9564dfeb7beebe3db18db732021-12-02T13:57:04ZDistinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates10.1038/s41467-020-20783-z2041-1723https://doaj.org/article/3f1e9178c9564dfeb7beebe3db18db732021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20783-zhttps://doaj.org/toc/2041-1723The tumor suppressor p53 is a master regulator of cellular stress response pathways, including cell cycle arrest and apoptosis. Here, the authors identify molecular mechanisms of p53 binding to high- and low-affinity p53 response elements in the genome, linked to cell cycle arrest and pro-apoptotic genes, respectively.Marina FarkasHideharu HashimotoYingtao BiRamana V. DavuluriLois Resnick-SilvermanJames J. ManfrediErik W. DeblerSteven B. McMahonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marina Farkas Hideharu Hashimoto Yingtao Bi Ramana V. Davuluri Lois Resnick-Silverman James J. Manfredi Erik W. Debler Steven B. McMahon Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates
description	The tumor suppressor p53 is a master regulator of cellular stress response pathways, including cell cycle arrest and apoptosis. Here, the authors identify molecular mechanisms of p53 binding to high- and low-affinity p53 response elements in the genome, linked to cell cycle arrest and pro-apoptotic genes, respectively.
format	article
author	Marina Farkas Hideharu Hashimoto Yingtao Bi Ramana V. Davuluri Lois Resnick-Silverman James J. Manfredi Erik W. Debler Steven B. McMahon
author_facet	Marina Farkas Hideharu Hashimoto Yingtao Bi Ramana V. Davuluri Lois Resnick-Silverman James J. Manfredi Erik W. Debler Steven B. McMahon
author_sort	Marina Farkas
title	Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates
title_short	Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates
title_full	Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates
title_fullStr	Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates
title_full_unstemmed	Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates
title_sort	distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3f1e9178c9564dfeb7beebe3db18db73
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Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates

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