Rationale for Processing of a Mg-Zn-Ca Alloy by Equal-Channel Angular Pressing for Use in Biodegradable Implants for Osteoreconstruction

Widespread use of Mg-Zn-Ca alloys in clinical orthopedic practice requires improvement of their mechanical properties—in particular, ductility—and enhancement of their bioactivity for accelerated osteoreconstruction. The alloy was studied in two structural states: after homogenization and after equa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Natalia S. Martynenko, Natalia Yu. Anisimova, Olga V. Rybalchenko, Mikhail V. Kiselevskiy, Georgy Rybalchenko, Boris Straumal, Diana Temralieva, Almagul T. Mansharipova, Aigul O. Kabiyeva, Maratbek T. Gabdullin, Sergey Dobatkin, Yuri Estrin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	magnesium alloy equal-channel angular pressing biodegradation biocompatibility alkaline phosphatase activity osteoconduction Crystallography QD901-999
Acceso en línea:	https://doaj.org/article/3f1f48b26fa94fd5a4d800388869eb26
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3f1f48b26fa94fd5a4d800388869eb26
record_format	dspace
spelling	oai:doaj.org-article:3f1f48b26fa94fd5a4d800388869eb262021-11-25T17:19:10ZRationale for Processing of a Mg-Zn-Ca Alloy by Equal-Channel Angular Pressing for Use in Biodegradable Implants for Osteoreconstruction10.3390/cryst111113812073-4352https://doaj.org/article/3f1f48b26fa94fd5a4d800388869eb262021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4352/11/11/1381https://doaj.org/toc/2073-4352Widespread use of Mg-Zn-Ca alloys in clinical orthopedic practice requires improvement of their mechanical properties—in particular, ductility—and enhancement of their bioactivity for accelerated osteoreconstruction. The alloy was studied in two structural states: after homogenization and after equal-channel angular pressing. Immersion and potentiodynamic polarization tests showed that the corrosion rate of the alloy was not increased by deformation. The mass loss in vivo was also statistically insignificant. Furthermore, it was found that deformation did not compromise the biocompatibility of the alloy and did not have any significant effect on cell adhesion and proliferation. However, an extract of the alloy promoted the alkaline phosphatase activity of human mesenchymal stromal cells, which indicates osteogenic stimulation of cells. The osteoinduction of the deformed alloy significantly exceeded that of the homogenized one. Based on the results of this work, it can be concluded that the alloy Mg-1%Zn-0.3%Ca modified by equal-channel angular pressing is a promising candidate for the manufacture of biodegradable orthopedic implants since it stimulates osteogenic differentiation and has greater ductility, which provides it with a competitive advantage in comparison with the homogenized state.Natalia S. MartynenkoNatalia Yu. AnisimovaOlga V. RybalchenkoMikhail V. KiselevskiyGeorgy RybalchenkoBoris StraumalDiana TemralievaAlmagul T. MansharipovaAigul O. KabiyevaMaratbek T. GabdullinSergey DobatkinYuri EstrinMDPI AGarticlemagnesium alloyequal-channel angular pressingbiodegradationbiocompatibilityalkaline phosphatase activityosteoconductionCrystallographyQD901-999ENCrystals, Vol 11, Iss 1381, p 1381 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	magnesium alloy equal-channel angular pressing biodegradation biocompatibility alkaline phosphatase activity osteoconduction Crystallography QD901-999
spellingShingle	magnesium alloy equal-channel angular pressing biodegradation biocompatibility alkaline phosphatase activity osteoconduction Crystallography QD901-999 Natalia S. Martynenko Natalia Yu. Anisimova Olga V. Rybalchenko Mikhail V. Kiselevskiy Georgy Rybalchenko Boris Straumal Diana Temralieva Almagul T. Mansharipova Aigul O. Kabiyeva Maratbek T. Gabdullin Sergey Dobatkin Yuri Estrin Rationale for Processing of a Mg-Zn-Ca Alloy by Equal-Channel Angular Pressing for Use in Biodegradable Implants for Osteoreconstruction
description	Widespread use of Mg-Zn-Ca alloys in clinical orthopedic practice requires improvement of their mechanical properties—in particular, ductility—and enhancement of their bioactivity for accelerated osteoreconstruction. The alloy was studied in two structural states: after homogenization and after equal-channel angular pressing. Immersion and potentiodynamic polarization tests showed that the corrosion rate of the alloy was not increased by deformation. The mass loss in vivo was also statistically insignificant. Furthermore, it was found that deformation did not compromise the biocompatibility of the alloy and did not have any significant effect on cell adhesion and proliferation. However, an extract of the alloy promoted the alkaline phosphatase activity of human mesenchymal stromal cells, which indicates osteogenic stimulation of cells. The osteoinduction of the deformed alloy significantly exceeded that of the homogenized one. Based on the results of this work, it can be concluded that the alloy Mg-1%Zn-0.3%Ca modified by equal-channel angular pressing is a promising candidate for the manufacture of biodegradable orthopedic implants since it stimulates osteogenic differentiation and has greater ductility, which provides it with a competitive advantage in comparison with the homogenized state.
format	article
author	Natalia S. Martynenko Natalia Yu. Anisimova Olga V. Rybalchenko Mikhail V. Kiselevskiy Georgy Rybalchenko Boris Straumal Diana Temralieva Almagul T. Mansharipova Aigul O. Kabiyeva Maratbek T. Gabdullin Sergey Dobatkin Yuri Estrin
author_facet	Natalia S. Martynenko Natalia Yu. Anisimova Olga V. Rybalchenko Mikhail V. Kiselevskiy Georgy Rybalchenko Boris Straumal Diana Temralieva Almagul T. Mansharipova Aigul O. Kabiyeva Maratbek T. Gabdullin Sergey Dobatkin Yuri Estrin
author_sort	Natalia S. Martynenko
title	Rationale for Processing of a Mg-Zn-Ca Alloy by Equal-Channel Angular Pressing for Use in Biodegradable Implants for Osteoreconstruction
title_short	Rationale for Processing of a Mg-Zn-Ca Alloy by Equal-Channel Angular Pressing for Use in Biodegradable Implants for Osteoreconstruction
title_full	Rationale for Processing of a Mg-Zn-Ca Alloy by Equal-Channel Angular Pressing for Use in Biodegradable Implants for Osteoreconstruction
title_fullStr	Rationale for Processing of a Mg-Zn-Ca Alloy by Equal-Channel Angular Pressing for Use in Biodegradable Implants for Osteoreconstruction
title_full_unstemmed	Rationale for Processing of a Mg-Zn-Ca Alloy by Equal-Channel Angular Pressing for Use in Biodegradable Implants for Osteoreconstruction
title_sort	rationale for processing of a mg-zn-ca alloy by equal-channel angular pressing for use in biodegradable implants for osteoreconstruction
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3f1f48b26fa94fd5a4d800388869eb26
work_keys_str_mv	AT nataliasmartynenko rationaleforprocessingofamgzncaalloybyequalchannelangularpressingforuseinbiodegradableimplantsforosteoreconstruction AT nataliayuanisimova rationaleforprocessingofamgzncaalloybyequalchannelangularpressingforuseinbiodegradableimplantsforosteoreconstruction AT olgavrybalchenko rationaleforprocessingofamgzncaalloybyequalchannelangularpressingforuseinbiodegradableimplantsforosteoreconstruction AT mikhailvkiselevskiy rationaleforprocessingofamgzncaalloybyequalchannelangularpressingforuseinbiodegradableimplantsforosteoreconstruction AT georgyrybalchenko rationaleforprocessingofamgzncaalloybyequalchannelangularpressingforuseinbiodegradableimplantsforosteoreconstruction AT borisstraumal rationaleforprocessingofamgzncaalloybyequalchannelangularpressingforuseinbiodegradableimplantsforosteoreconstruction AT dianatemralieva rationaleforprocessingofamgzncaalloybyequalchannelangularpressingforuseinbiodegradableimplantsforosteoreconstruction AT almagultmansharipova rationaleforprocessingofamgzncaalloybyequalchannelangularpressingforuseinbiodegradableimplantsforosteoreconstruction AT aigulokabiyeva rationaleforprocessingofamgzncaalloybyequalchannelangularpressingforuseinbiodegradableimplantsforosteoreconstruction AT maratbektgabdullin rationaleforprocessingofamgzncaalloybyequalchannelangularpressingforuseinbiodegradableimplantsforosteoreconstruction AT sergeydobatkin rationaleforprocessingofamgzncaalloybyequalchannelangularpressingforuseinbiodegradableimplantsforosteoreconstruction AT yuriestrin rationaleforprocessingofamgzncaalloybyequalchannelangularpressingforuseinbiodegradableimplantsforosteoreconstruction
_version_	1718412524779470848

Rationale for Processing of a Mg-Zn-Ca Alloy by Equal-Channel Angular Pressing for Use in Biodegradable Implants for Osteoreconstruction

Ejemplares similares