Risk and mortality of aspiration pneumonia in Parkinson’s disease: a nationwide database study

Abstract This retrospective cohort study investigated the risk and mortality rate due to aspiration pneumonia in patients with Parkinson’s disease (PD) using a nationwide database. We identified 10,159 newly diagnosed PD patients between 2004 and 2006, and four age- and sex-matched controls for each...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jun Hee Won, Seong Jun Byun, Byung-Mo Oh, Sang Jun Park, Han Gil Seo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3f2058d66373455fac0d85ad172e5c15
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3f2058d66373455fac0d85ad172e5c15
record_format	dspace
spelling	oai:doaj.org-article:3f2058d66373455fac0d85ad172e5c152021-12-02T16:36:04ZRisk and mortality of aspiration pneumonia in Parkinson’s disease: a nationwide database study10.1038/s41598-021-86011-w2045-2322https://doaj.org/article/3f2058d66373455fac0d85ad172e5c152021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86011-whttps://doaj.org/toc/2045-2322Abstract This retrospective cohort study investigated the risk and mortality rate due to aspiration pneumonia in patients with Parkinson’s disease (PD) using a nationwide database. We identified 10,159 newly diagnosed PD patients between 2004 and 2006, and four age- and sex-matched controls for each PD patient from the National Health Insurance Service database in Korea. We analyzed the relative risk of aspiration pneumonia and mortality after the first occurrence of aspiration pneumonia until 2017. Throughout the study period, PD patients showed a higher incidence of aspiration pneumonia than their matched controls (3.01 vs. 0.59 events per 1,000 person-years), and they were at an increased risk of aspiration pneumonia (hazard ratio = 4.21; 95% confidence interval, 3.87–4.58). After the first occurrence of aspiration pneumonia, the mortality rate of PD patients was 23.9% after one month, 65.2% after 1 year, and 91.8% after 5 years, while that of controls was 30.9%, 67.4%, and 88.9%, respectively. Patients with PD are at an increased risk of aspiration pneumonia, and approximately two-thirds of the patients die within a year after experiencing aspiration pneumonia. Further studies are warranted to prevent aspiration pneumonia and implement proper treatments to prevent death after aspiration pneumonia in patients with PD.Jun Hee WonSeong Jun ByunByung-Mo OhSang Jun ParkHan Gil SeoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jun Hee Won Seong Jun Byun Byung-Mo Oh Sang Jun Park Han Gil Seo Risk and mortality of aspiration pneumonia in Parkinson’s disease: a nationwide database study
description	Abstract This retrospective cohort study investigated the risk and mortality rate due to aspiration pneumonia in patients with Parkinson’s disease (PD) using a nationwide database. We identified 10,159 newly diagnosed PD patients between 2004 and 2006, and four age- and sex-matched controls for each PD patient from the National Health Insurance Service database in Korea. We analyzed the relative risk of aspiration pneumonia and mortality after the first occurrence of aspiration pneumonia until 2017. Throughout the study period, PD patients showed a higher incidence of aspiration pneumonia than their matched controls (3.01 vs. 0.59 events per 1,000 person-years), and they were at an increased risk of aspiration pneumonia (hazard ratio = 4.21; 95% confidence interval, 3.87–4.58). After the first occurrence of aspiration pneumonia, the mortality rate of PD patients was 23.9% after one month, 65.2% after 1 year, and 91.8% after 5 years, while that of controls was 30.9%, 67.4%, and 88.9%, respectively. Patients with PD are at an increased risk of aspiration pneumonia, and approximately two-thirds of the patients die within a year after experiencing aspiration pneumonia. Further studies are warranted to prevent aspiration pneumonia and implement proper treatments to prevent death after aspiration pneumonia in patients with PD.
format	article
author	Jun Hee Won Seong Jun Byun Byung-Mo Oh Sang Jun Park Han Gil Seo
author_facet	Jun Hee Won Seong Jun Byun Byung-Mo Oh Sang Jun Park Han Gil Seo
author_sort	Jun Hee Won
title	Risk and mortality of aspiration pneumonia in Parkinson’s disease: a nationwide database study
title_short	Risk and mortality of aspiration pneumonia in Parkinson’s disease: a nationwide database study
title_full	Risk and mortality of aspiration pneumonia in Parkinson’s disease: a nationwide database study
title_fullStr	Risk and mortality of aspiration pneumonia in Parkinson’s disease: a nationwide database study
title_full_unstemmed	Risk and mortality of aspiration pneumonia in Parkinson’s disease: a nationwide database study
title_sort	risk and mortality of aspiration pneumonia in parkinson’s disease: a nationwide database study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3f2058d66373455fac0d85ad172e5c15
work_keys_str_mv	AT junheewon riskandmortalityofaspirationpneumoniainparkinsonsdiseaseanationwidedatabasestudy AT seongjunbyun riskandmortalityofaspirationpneumoniainparkinsonsdiseaseanationwidedatabasestudy AT byungmooh riskandmortalityofaspirationpneumoniainparkinsonsdiseaseanationwidedatabasestudy AT sangjunpark riskandmortalityofaspirationpneumoniainparkinsonsdiseaseanationwidedatabasestudy AT hangilseo riskandmortalityofaspirationpneumoniainparkinsonsdiseaseanationwidedatabasestudy
_version_	1718383626500964352

Risk and mortality of aspiration pneumonia in Parkinson’s disease: a nationwide database study

Ejemplares similares