Calcium stabilizes the strongest protein fold

Staphylococcal pathogens adhere to their human targets using adhesins, which can withstand extremely high forces. Here, authors use single-molecule force spectroscopy to determine the similarly high unfolding forces of B domains that link the adhesin to the bacterium.

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Autores principales:	Lukas F. Milles, Eduard M. Unterauer, Thomas Nicolaus, Hermann E. Gaub
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3f2523c006d44bfc9a24d45ca7291cb5
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spelling	oai:doaj.org-article:3f2523c006d44bfc9a24d45ca7291cb52021-12-02T16:49:18ZCalcium stabilizes the strongest protein fold10.1038/s41467-018-07145-62041-1723https://doaj.org/article/3f2523c006d44bfc9a24d45ca7291cb52018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07145-6https://doaj.org/toc/2041-1723Staphylococcal pathogens adhere to their human targets using adhesins, which can withstand extremely high forces. Here, authors use single-molecule force spectroscopy to determine the similarly high unfolding forces of B domains that link the adhesin to the bacterium.Lukas F. MillesEduard M. UnterauerThomas NicolausHermann E. GaubNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lukas F. Milles Eduard M. Unterauer Thomas Nicolaus Hermann E. Gaub Calcium stabilizes the strongest protein fold
description	Staphylococcal pathogens adhere to their human targets using adhesins, which can withstand extremely high forces. Here, authors use single-molecule force spectroscopy to determine the similarly high unfolding forces of B domains that link the adhesin to the bacterium.
format	article
author	Lukas F. Milles Eduard M. Unterauer Thomas Nicolaus Hermann E. Gaub
author_facet	Lukas F. Milles Eduard M. Unterauer Thomas Nicolaus Hermann E. Gaub
author_sort	Lukas F. Milles
title	Calcium stabilizes the strongest protein fold
title_short	Calcium stabilizes the strongest protein fold
title_full	Calcium stabilizes the strongest protein fold
title_fullStr	Calcium stabilizes the strongest protein fold
title_full_unstemmed	Calcium stabilizes the strongest protein fold
title_sort	calcium stabilizes the strongest protein fold
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3f2523c006d44bfc9a24d45ca7291cb5
work_keys_str_mv	AT lukasfmilles calciumstabilizesthestrongestproteinfold AT eduardmunterauer calciumstabilizesthestrongestproteinfold AT thomasnicolaus calciumstabilizesthestrongestproteinfold AT hermannegaub calciumstabilizesthestrongestproteinfold
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Calcium stabilizes the strongest protein fold

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