Can Serum Nutritional Related Biomarkers Predict Mortality Of Critically Ill Older Patients With Acute Kidney Injury?

Yu Gong,1 Feng Ding,2 Yong Gu2 1Department of Internal Medicine, Division of Nephrology, Shanghai Municipal Eighth People’s Hospital, Shanghai, People’s Republic of China; 2Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, People’s Republic of ChinaC...

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Autores principales:	Gong Y, Ding F, Gu Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Critically ill older patients acute kidney injury mortality nutritional related biomarker Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/3f2736f1695d4231981982dfe9a71511
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spelling	oai:doaj.org-article:3f2736f1695d4231981982dfe9a715112021-12-02T06:15:35ZCan Serum Nutritional Related Biomarkers Predict Mortality Of Critically Ill Older Patients With Acute Kidney Injury?1178-1998https://doaj.org/article/3f2736f1695d4231981982dfe9a715112019-10-01T00:00:00Zhttps://www.dovepress.com/can-serum-nutritional-related-biomarkers-predict-mortality-of-critical-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Yu Gong,1 Feng Ding,2 Yong Gu2 1Department of Internal Medicine, Division of Nephrology, Shanghai Municipal Eighth People’s Hospital, Shanghai, People’s Republic of China; 2Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence: Yu GongDepartment of Internal Medicine, Division of Nephrology, Shanghai Municipal Eighth People’s Hospital, 8 Caobao Road, Shanghai 200235, People’s Republic of ChinaTel +86 21 18930718612Email gyfd66@126.comBackground: Critically ill older patients with acute kidney injury (AKI), also referred to as acute renal failure, are associated with high in-hospital mortalities. Preexisting malnutrition is highly prevalent among AKI patients and increases in-hospital mortality rate. This study is to evaluate the predictive power of some serum nutritional related biomarkers predicting the 90 days in-hospital mortality of critically ill older patients with AKI.Methods: A prospective, observational study was conducted in a university teaching hospital. One hundred and five critically ill older patients with AKI aged 60–95 were enrolled and were divided into survival group (n=44) and non-survival group (n=61) in the light of their final outcomes. Receiver operating characteristic analyses (ROC) were performed to calculate the area under ROC curve (AUC). Sensitivity and specificity of in-hospital mortality prediction were calculated.Results: Significant differences were found between the survival group and non-survival group of critically ill older patients with AKI. AUC of low density lipoprotein (LDL) and albumin were 0.686 and 0.595, respectively. The asymptotic 95% confidence intervals of LDL and albumin were 0.524–0.820 and 0.488–0.696, respectively. Sensitivity of the 90 days in-hospital mortality prediction of LDL and albumin were 68.71% and 69.09%, respectively. Specificity of 90 days in-hospital mortality prediction of LDL and albumin were 69.23% and 50.0%, respectively.Conclusion: LDL and albumin did not have sufficient power to predict the 90 days in-hospital mortality of critically ill older patients with AKI. Further research on the association between malnutrition and poor prognosis of critically ill older patients with AKI is needed in the future.Trial registration: ClinicalTrials.gov identifier: NCT00953992.Keywords: critically ill older patients, acute kidney injury, mortality, nutritional related biomarkerGong YDing FGu YDove Medical PressarticleCritically ill older patientsacute kidney injurymortalitynutritional related biomarkerGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 1763-1769 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Critically ill older patients acute kidney injury mortality nutritional related biomarker Geriatrics RC952-954.6
spellingShingle	Critically ill older patients acute kidney injury mortality nutritional related biomarker Geriatrics RC952-954.6 Gong Y Ding F Gu Y Can Serum Nutritional Related Biomarkers Predict Mortality Of Critically Ill Older Patients With Acute Kidney Injury?
description	Yu Gong,1 Feng Ding,2 Yong Gu2 1Department of Internal Medicine, Division of Nephrology, Shanghai Municipal Eighth People’s Hospital, Shanghai, People’s Republic of China; 2Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, People’s Republic of ChinaCorrespondence: Yu GongDepartment of Internal Medicine, Division of Nephrology, Shanghai Municipal Eighth People’s Hospital, 8 Caobao Road, Shanghai 200235, People’s Republic of ChinaTel +86 21 18930718612Email gyfd66@126.comBackground: Critically ill older patients with acute kidney injury (AKI), also referred to as acute renal failure, are associated with high in-hospital mortalities. Preexisting malnutrition is highly prevalent among AKI patients and increases in-hospital mortality rate. This study is to evaluate the predictive power of some serum nutritional related biomarkers predicting the 90 days in-hospital mortality of critically ill older patients with AKI.Methods: A prospective, observational study was conducted in a university teaching hospital. One hundred and five critically ill older patients with AKI aged 60–95 were enrolled and were divided into survival group (n=44) and non-survival group (n=61) in the light of their final outcomes. Receiver operating characteristic analyses (ROC) were performed to calculate the area under ROC curve (AUC). Sensitivity and specificity of in-hospital mortality prediction were calculated.Results: Significant differences were found between the survival group and non-survival group of critically ill older patients with AKI. AUC of low density lipoprotein (LDL) and albumin were 0.686 and 0.595, respectively. The asymptotic 95% confidence intervals of LDL and albumin were 0.524–0.820 and 0.488–0.696, respectively. Sensitivity of the 90 days in-hospital mortality prediction of LDL and albumin were 68.71% and 69.09%, respectively. Specificity of 90 days in-hospital mortality prediction of LDL and albumin were 69.23% and 50.0%, respectively.Conclusion: LDL and albumin did not have sufficient power to predict the 90 days in-hospital mortality of critically ill older patients with AKI. Further research on the association between malnutrition and poor prognosis of critically ill older patients with AKI is needed in the future.Trial registration: ClinicalTrials.gov identifier: NCT00953992.Keywords: critically ill older patients, acute kidney injury, mortality, nutritional related biomarker
format	article
author	Gong Y Ding F Gu Y
author_facet	Gong Y Ding F Gu Y
author_sort	Gong Y
title	Can Serum Nutritional Related Biomarkers Predict Mortality Of Critically Ill Older Patients With Acute Kidney Injury?
title_short	Can Serum Nutritional Related Biomarkers Predict Mortality Of Critically Ill Older Patients With Acute Kidney Injury?
title_full	Can Serum Nutritional Related Biomarkers Predict Mortality Of Critically Ill Older Patients With Acute Kidney Injury?
title_fullStr	Can Serum Nutritional Related Biomarkers Predict Mortality Of Critically Ill Older Patients With Acute Kidney Injury?
title_full_unstemmed	Can Serum Nutritional Related Biomarkers Predict Mortality Of Critically Ill Older Patients With Acute Kidney Injury?
title_sort	can serum nutritional related biomarkers predict mortality of critically ill older patients with acute kidney injury?
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/3f2736f1695d4231981982dfe9a71511
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Can Serum Nutritional Related Biomarkers Predict Mortality Of Critically Ill Older Patients With Acute Kidney Injury?

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