Assessment of Three New Loci from Genome-wide Association Study in Essential Tremor in Chinese population

Abstract Essential tremor (ET) is the most common tremor disorder. Evidences indicated that genetics plays an essential role in the researches of etiology. A new genome-wide association study (GWAS) from European population identified three novel loci in ET, which were rs10937625 in STK32B, rs175900...

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Autores principales:	Yuan Zhang, Yuwen Zhao, Xiaoting Zhou, Kai Li, Minhan Yi, Jifeng Guo, Xinxiang Yan, Beisha Tang, Qiying Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3f2a296479cf4dabbddf15a310346328
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spelling	oai:doaj.org-article:3f2a296479cf4dabbddf15a3103463282021-12-02T16:07:04ZAssessment of Three New Loci from Genome-wide Association Study in Essential Tremor in Chinese population10.1038/s41598-017-08863-52045-2322https://doaj.org/article/3f2a296479cf4dabbddf15a3103463282017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08863-5https://doaj.org/toc/2045-2322Abstract Essential tremor (ET) is the most common tremor disorder. Evidences indicated that genetics plays an essential role in the researches of etiology. A new genome-wide association study (GWAS) from European population identified three novel loci in ET, which were rs10937625 in STK32B, rs17590046 in PPARGC1A, and rs12764057, rs10822974 and rs7903491 in CTNNA3. Due to the different genetic background in different population, we performed a case-control study to investigate these variants in a cohort of 533 subjects in Chinese population. We found a significant difference in the distributions of genotypes and alleles frequencies between ET and control groups of rs10937625 (genotype p = 0.037, OR = 0.69[0.48–0.98]; allele p = 0.033, OR = 0.82[0.69–0.99]) and rs7903491 (genotype p = 0.030, OR = 1.34[1.03–1.74]; allele p = 0.029, OR = 1.16[1.02–1.32]) after adjusted for age and gender. And no associations were detected between rs17590046 (genotype p = 0.794; allele p = 0.791), rs12764057 (genotype p = 0.337; allele p = 0.337), rs10822974 (genotype p = 0.102; allele p = 0.100) and ET in Chinese population individually. Our research supports that C allele of rs10937625 in STK32B is a protective factor and G allele of rs7903491 in CTNNA3 is a risk factor for ET in Chinese population.Yuan ZhangYuwen ZhaoXiaoting ZhouKai LiMinhan YiJifeng GuoXinxiang YanBeisha TangQiying SunNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-5 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuan Zhang Yuwen Zhao Xiaoting Zhou Kai Li Minhan Yi Jifeng Guo Xinxiang Yan Beisha Tang Qiying Sun Assessment of Three New Loci from Genome-wide Association Study in Essential Tremor in Chinese population
description	Abstract Essential tremor (ET) is the most common tremor disorder. Evidences indicated that genetics plays an essential role in the researches of etiology. A new genome-wide association study (GWAS) from European population identified three novel loci in ET, which were rs10937625 in STK32B, rs17590046 in PPARGC1A, and rs12764057, rs10822974 and rs7903491 in CTNNA3. Due to the different genetic background in different population, we performed a case-control study to investigate these variants in a cohort of 533 subjects in Chinese population. We found a significant difference in the distributions of genotypes and alleles frequencies between ET and control groups of rs10937625 (genotype p = 0.037, OR = 0.69[0.48–0.98]; allele p = 0.033, OR = 0.82[0.69–0.99]) and rs7903491 (genotype p = 0.030, OR = 1.34[1.03–1.74]; allele p = 0.029, OR = 1.16[1.02–1.32]) after adjusted for age and gender. And no associations were detected between rs17590046 (genotype p = 0.794; allele p = 0.791), rs12764057 (genotype p = 0.337; allele p = 0.337), rs10822974 (genotype p = 0.102; allele p = 0.100) and ET in Chinese population individually. Our research supports that C allele of rs10937625 in STK32B is a protective factor and G allele of rs7903491 in CTNNA3 is a risk factor for ET in Chinese population.
format	article
author	Yuan Zhang Yuwen Zhao Xiaoting Zhou Kai Li Minhan Yi Jifeng Guo Xinxiang Yan Beisha Tang Qiying Sun
author_facet	Yuan Zhang Yuwen Zhao Xiaoting Zhou Kai Li Minhan Yi Jifeng Guo Xinxiang Yan Beisha Tang Qiying Sun
author_sort	Yuan Zhang
title	Assessment of Three New Loci from Genome-wide Association Study in Essential Tremor in Chinese population
title_short	Assessment of Three New Loci from Genome-wide Association Study in Essential Tremor in Chinese population
title_full	Assessment of Three New Loci from Genome-wide Association Study in Essential Tremor in Chinese population
title_fullStr	Assessment of Three New Loci from Genome-wide Association Study in Essential Tremor in Chinese population
title_full_unstemmed	Assessment of Three New Loci from Genome-wide Association Study in Essential Tremor in Chinese population
title_sort	assessment of three new loci from genome-wide association study in essential tremor in chinese population
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3f2a296479cf4dabbddf15a310346328
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Assessment of Three New Loci from Genome-wide Association Study in Essential Tremor in Chinese population

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