Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation

Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation

Some anticancer drugs target cell microtubules inhibiting mitosis and cell division. Here, the authors show that CRMP2 induces microtubule bundling and that this activity is regulated by the FER kinase, thus providing a rationale for targeting FER in combination with microtubule-targeting drugs.

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Autores principales: Yiyan Zheng, Ritika Sethi, Lingegowda S. Mangala, Charlotte Taylor, Juliet Goldsmith, Ming Wang, Kenta Masuda, Mohammad Karaminejadranjbar, David Mannion, Fabrizio Miranda, Sandra Herrero-Gonzalez, Karin Hellner, Fiona Chen, Abdulkhaliq Alsaadi, Ashwag Albukhari, Donatien Chedom Fotso, Christopher Yau, Dahai Jiang, Sunila Pradeep, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Stefan Knapp, Nathanael S. Gray, Leticia Campo, Kevin A. Myers, Sunanda Dhar, David Ferguson, Robert C. Bast, Anil K. Sood, Frank von Delft, Ahmed Ashour Ahmed
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/3f3066d1a6b14342a99fe65262e6ce95
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spelling oai:doaj.org-article:3f3066d1a6b14342a99fe65262e6ce952021-12-02T17:32:47ZTuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation10.1038/s41467-017-02811-72041-1723https://doaj.org/article/3f3066d1a6b14342a99fe65262e6ce952018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02811-7https://doaj.org/toc/2041-1723Some anticancer drugs target cell microtubules inhibiting mitosis and cell division. Here, the authors show that CRMP2 induces microtubule bundling and that this activity is regulated by the FER kinase, thus providing a rationale for targeting FER in combination with microtubule-targeting drugs.Yiyan ZhengRitika SethiLingegowda S. MangalaCharlotte TaylorJuliet GoldsmithMing WangKenta MasudaMohammad KaraminejadranjbarDavid MannionFabrizio MirandaSandra Herrero-GonzalezKarin HellnerFiona ChenAbdulkhaliq AlsaadiAshwag AlbukhariDonatien Chedom FotsoChristopher YauDahai JiangSunila PradeepCristian Rodriguez-AguayoGabriel Lopez-BeresteinStefan KnappNathanael S. GrayLeticia CampoKevin A. MyersSunanda DharDavid FergusonRobert C. BastAnil K. SoodFrank von DelftAhmed Ashour AhmedNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yiyan Zheng
Ritika Sethi
Lingegowda S. Mangala
Charlotte Taylor
Juliet Goldsmith
Ming Wang
Kenta Masuda
Mohammad Karaminejadranjbar
David Mannion
Fabrizio Miranda
Sandra Herrero-Gonzalez
Karin Hellner
Fiona Chen
Abdulkhaliq Alsaadi
Ashwag Albukhari
Donatien Chedom Fotso
Christopher Yau
Dahai Jiang
Sunila Pradeep
Cristian Rodriguez-Aguayo
Gabriel Lopez-Berestein
Stefan Knapp
Nathanael S. Gray
Leticia Campo
Kevin A. Myers
Sunanda Dhar
David Ferguson
Robert C. Bast
Anil K. Sood
Frank von Delft
Ahmed Ashour Ahmed
Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation
description Some anticancer drugs target cell microtubules inhibiting mitosis and cell division. Here, the authors show that CRMP2 induces microtubule bundling and that this activity is regulated by the FER kinase, thus providing a rationale for targeting FER in combination with microtubule-targeting drugs.
format article
author Yiyan Zheng
Ritika Sethi
Lingegowda S. Mangala
Charlotte Taylor
Juliet Goldsmith
Ming Wang
Kenta Masuda
Mohammad Karaminejadranjbar
David Mannion
Fabrizio Miranda
Sandra Herrero-Gonzalez
Karin Hellner
Fiona Chen
Abdulkhaliq Alsaadi
Ashwag Albukhari
Donatien Chedom Fotso
Christopher Yau
Dahai Jiang
Sunila Pradeep
Cristian Rodriguez-Aguayo
Gabriel Lopez-Berestein
Stefan Knapp
Nathanael S. Gray
Leticia Campo
Kevin A. Myers
Sunanda Dhar
David Ferguson
Robert C. Bast
Anil K. Sood
Frank von Delft
Ahmed Ashour Ahmed
author_facet Yiyan Zheng
Ritika Sethi
Lingegowda S. Mangala
Charlotte Taylor
Juliet Goldsmith
Ming Wang
Kenta Masuda
Mohammad Karaminejadranjbar
David Mannion
Fabrizio Miranda
Sandra Herrero-Gonzalez
Karin Hellner
Fiona Chen
Abdulkhaliq Alsaadi
Ashwag Albukhari
Donatien Chedom Fotso
Christopher Yau
Dahai Jiang
Sunila Pradeep
Cristian Rodriguez-Aguayo
Gabriel Lopez-Berestein
Stefan Knapp
Nathanael S. Gray
Leticia Campo
Kevin A. Myers
Sunanda Dhar
David Ferguson
Robert C. Bast
Anil K. Sood
Frank von Delft
Ahmed Ashour Ahmed
author_sort Yiyan Zheng
title Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation
title_short Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation
title_full Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation
title_fullStr Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation
title_full_unstemmed Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation
title_sort tuning microtubule dynamics to enhance cancer therapy by modulating fer-mediated crmp2 phosphorylation
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/3f3066d1a6b14342a99fe65262e6ce95
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