Exploration of Xanthone Derivatives as Anti-Cancer Agents against Colorectal Cancer

Colorectal cancer currently occupies the third position of globally cancer morbidity and is the second leading cause of cancer death after lung cancer. Chemotherapy administration is still the main modality for the colorectal cancer stage I to III. Its usage is limited, since its high resistance and...

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Autor principal:	Isnatin Miladiyah
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Sultan Agung Semarang 2020
Materias:	colorectal cancer xanthone derivatives apoptosis cell cycle synergistic effect Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3f349b4b803d48eba448a127d5cf65fa
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spelling	oai:doaj.org-article:3f349b4b803d48eba448a127d5cf65fa2021-11-25T13:16:36ZExploration of Xanthone Derivatives as Anti-Cancer Agents against Colorectal Cancer2085-15452339-093X10.30659/sainsmed.v11i1.7681https://doaj.org/article/3f349b4b803d48eba448a127d5cf65fa2020-07-01T00:00:00Zhttp://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/7681https://doaj.org/toc/2085-1545https://doaj.org/toc/2339-093XColorectal cancer currently occupies the third position of globally cancer morbidity and is the second leading cause of cancer death after lung cancer. Chemotherapy administration is still the main modality for the colorectal cancer stage I to III. Its usage is limited, since its high resistance and risk of side effects. Thus, exploration and development of novel colorectal anti-cancer drugs, including compounds derived from nature origin is needed. Xanthone becomes one natural compound which may be potentially developed as an anti-colorectal cancer due to its cytotoxic and anti-proliferative activities. The in vitro cytotoxic and anti-proliferative actions of xanthone compounds occur through a variety of mechanisms involving both apoptotic induction and inhibition of cell cycle, while in vivo may reduce the tumor size. Since colorectal cancer is frequently treated in a combination therapy, xanthone compounds have also been studied in a combination use and proven effective as co-chemotherapy with the standard chemotherapy drugs. This paper aims at providing an overview of colorectal cancer, pathology, risk factors and protective factors, as well as discussing the current therapies and potential xanthone compounds as an alternative therapy which may be developed later for the colorectal cancerIsnatin MiladiyahUniversitas Sultan Agung Semarangarticlecolorectal cancerxanthone derivativesapoptosiscell cyclesynergistic effectMedicine (General)R5-920ENSains Medika, Vol 11, Iss 1, Pp 33-41 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal cancer xanthone derivatives apoptosis cell cycle synergistic effect Medicine (General) R5-920
spellingShingle	colorectal cancer xanthone derivatives apoptosis cell cycle synergistic effect Medicine (General) R5-920 Isnatin Miladiyah Exploration of Xanthone Derivatives as Anti-Cancer Agents against Colorectal Cancer
description	Colorectal cancer currently occupies the third position of globally cancer morbidity and is the second leading cause of cancer death after lung cancer. Chemotherapy administration is still the main modality for the colorectal cancer stage I to III. Its usage is limited, since its high resistance and risk of side effects. Thus, exploration and development of novel colorectal anti-cancer drugs, including compounds derived from nature origin is needed. Xanthone becomes one natural compound which may be potentially developed as an anti-colorectal cancer due to its cytotoxic and anti-proliferative activities. The in vitro cytotoxic and anti-proliferative actions of xanthone compounds occur through a variety of mechanisms involving both apoptotic induction and inhibition of cell cycle, while in vivo may reduce the tumor size. Since colorectal cancer is frequently treated in a combination therapy, xanthone compounds have also been studied in a combination use and proven effective as co-chemotherapy with the standard chemotherapy drugs. This paper aims at providing an overview of colorectal cancer, pathology, risk factors and protective factors, as well as discussing the current therapies and potential xanthone compounds as an alternative therapy which may be developed later for the colorectal cancer
format	article
author	Isnatin Miladiyah
author_facet	Isnatin Miladiyah
author_sort	Isnatin Miladiyah
title	Exploration of Xanthone Derivatives as Anti-Cancer Agents against Colorectal Cancer
title_short	Exploration of Xanthone Derivatives as Anti-Cancer Agents against Colorectal Cancer
title_full	Exploration of Xanthone Derivatives as Anti-Cancer Agents against Colorectal Cancer
title_fullStr	Exploration of Xanthone Derivatives as Anti-Cancer Agents against Colorectal Cancer
title_full_unstemmed	Exploration of Xanthone Derivatives as Anti-Cancer Agents against Colorectal Cancer
title_sort	exploration of xanthone derivatives as anti-cancer agents against colorectal cancer
publisher	Universitas Sultan Agung Semarang
publishDate	2020
url	https://doaj.org/article/3f349b4b803d48eba448a127d5cf65fa
work_keys_str_mv	AT isnatinmiladiyah explorationofxanthonederivativesasanticanceragentsagainstcolorectalcancer
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Exploration of Xanthone Derivatives as Anti-Cancer Agents against Colorectal Cancer

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