Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization

The presence of long-lived memory IgA-producing B cells in the intestine has been difficult to document. Here the authors show that these cells can be induced by oral but not systemic immunization in mice, and characterize unique features that distinguish them from IgA plasma cells.

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Autores principales:	Mats Bemark, Helena Hazanov, Anneli Strömberg, Rathan Komban, Joel Holmqvist, Sofia Köster, Johan Mattsson, Per Sikora, Ramit Mehr, Nils Y. Lycke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3f378a82abe14213ae3c6b066e47eba1
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spelling	oai:doaj.org-article:3f378a82abe14213ae3c6b066e47eba12021-12-02T15:34:30ZLimited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization10.1038/ncomms126982041-1723https://doaj.org/article/3f378a82abe14213ae3c6b066e47eba12016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12698https://doaj.org/toc/2041-1723The presence of long-lived memory IgA-producing B cells in the intestine has been difficult to document. Here the authors show that these cells can be induced by oral but not systemic immunization in mice, and characterize unique features that distinguish them from IgA plasma cells.Mats BemarkHelena HazanovAnneli StrömbergRathan KombanJoel HolmqvistSofia KösterJohan MattssonPer SikoraRamit MehrNils Y. LyckeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mats Bemark Helena Hazanov Anneli Strömberg Rathan Komban Joel Holmqvist Sofia Köster Johan Mattsson Per Sikora Ramit Mehr Nils Y. Lycke Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization
description	The presence of long-lived memory IgA-producing B cells in the intestine has been difficult to document. Here the authors show that these cells can be induced by oral but not systemic immunization in mice, and characterize unique features that distinguish them from IgA plasma cells.
format	article
author	Mats Bemark Helena Hazanov Anneli Strömberg Rathan Komban Joel Holmqvist Sofia Köster Johan Mattsson Per Sikora Ramit Mehr Nils Y. Lycke
author_facet	Mats Bemark Helena Hazanov Anneli Strömberg Rathan Komban Joel Holmqvist Sofia Köster Johan Mattsson Per Sikora Ramit Mehr Nils Y. Lycke
author_sort	Mats Bemark
title	Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization
title_short	Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization
title_full	Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization
title_fullStr	Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization
title_full_unstemmed	Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization
title_sort	limited clonal relatedness between gut iga plasma cells and memory b cells after oral immunization
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3f378a82abe14213ae3c6b066e47eba1
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Limited clonal relatedness between gut IgA plasma cells and memory B cells after oral immunization

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