Changes in peripapillary and subfoveal choroidal thickness in patients with central retinal vein occlusion.

<h4>Purpose</h4>We sought to evaluate changes of mean peripapillary choroidal thickness (PCT) and subfoveal choroidal thickness (SFCT) over 12 months in patients with unilateral central retinal vein occlusion (CRVO).<h4>Methods</h4>Our retrospective, observational study inclu...

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Autores principales:	Hae Min Kang, Jeong Hoon Choi, Hyoung Jun Koh, Sung Chul Lee
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3f393ec29ac349efb8d7ee4ae348b21e
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spelling	oai:doaj.org-article:3f393ec29ac349efb8d7ee4ae348b21e2021-12-02T20:14:57ZChanges in peripapillary and subfoveal choroidal thickness in patients with central retinal vein occlusion.1932-620310.1371/journal.pone.0255182https://doaj.org/article/3f393ec29ac349efb8d7ee4ae348b21e2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255182https://doaj.org/toc/1932-6203<h4>Purpose</h4>We sought to evaluate changes of mean peripapillary choroidal thickness (PCT) and subfoveal choroidal thickness (SFCT) over 12 months in patients with unilateral central retinal vein occlusion (CRVO).<h4>Methods</h4>Our retrospective, observational study included 19 patients with treatment-naïve, unilateral CRVO who completed at least 12 months of follow-up period. Mean PCT and mean SFCT in CRVO-affected eyes and unaffected contralateral eyes were measured at each follow-up visit, and then compared. Differences between baseline and 12 months (ΔSFCT and ΔPCT) and percentage changes (ΔSFCT or ΔPCT/baseline×100%) were determined. We also investigated the predictive factors for visual outcome in the CRVO-affected eyes.<h4>Results</h4>In the CRVO-affected eyes, mean PCT was 146.7±41.9 μm at baseline, and 106.5±24.2 μm at 12 months (P < 0.001). Mean PCT of the contralateral eyes was 129.8±42.6 μm at baseline and 124.6±39.7 μm at 12 months (P = 0.089). Mean SFCT of CRVO-affected eyes was 225.8±77.9 μm at baseline, and 199.4±66.6 μm at 12 months (P = 0.009). Mean SFCT of the contralateral eyes was 218.4±83.0 μm at baseline, and 208.4±78.1 μm at 12 months (P = 0.089). Δ PCT was -41.6±25.3 μm in the CRVO-affected eyes, and -5.2±5.8 μm in the contralateral eyes (P<0.001). % PCT was -24.9±14.0% in the CRVO-affected eyes, and -4.0±0.4% in the contralateral eyes (P = 0.001). Δ SFCT was -26.4±24.6 μm in the CRVO-affected eyes, and -9.5±16.7μm in the contralateral eyes (P = 0.016). % SFCT was -10.4±9.8% in the CRVO-affected eyes, and -3.4±6.4% in the contralateral eyes (P = 0.015). Among the various factors, BCVA at baseline (β = 0.797, P = 0.001) and % SFCT (β = 0.712, P = 0.001) were significantly associated with visual outcome at 12 months in the CRVO-affected eyes.<h4>Conclusion</h4>Both peripapillary and subfoveal choroidal thickness reduced significantly over 12 months in the CRVO-affected eyes, but not in the contralateral eyes. In addition, the absolute reduction amount and reduction ratio of PCT and SFCT were significantly greater in the CRVO-affected eyes than the contralateral eyes.Hae Min KangJeong Hoon ChoiHyoung Jun KohSung Chul LeePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255182 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hae Min Kang Jeong Hoon Choi Hyoung Jun Koh Sung Chul Lee Changes in peripapillary and subfoveal choroidal thickness in patients with central retinal vein occlusion.
description	<h4>Purpose</h4>We sought to evaluate changes of mean peripapillary choroidal thickness (PCT) and subfoveal choroidal thickness (SFCT) over 12 months in patients with unilateral central retinal vein occlusion (CRVO).<h4>Methods</h4>Our retrospective, observational study included 19 patients with treatment-naïve, unilateral CRVO who completed at least 12 months of follow-up period. Mean PCT and mean SFCT in CRVO-affected eyes and unaffected contralateral eyes were measured at each follow-up visit, and then compared. Differences between baseline and 12 months (ΔSFCT and ΔPCT) and percentage changes (ΔSFCT or ΔPCT/baseline×100%) were determined. We also investigated the predictive factors for visual outcome in the CRVO-affected eyes.<h4>Results</h4>In the CRVO-affected eyes, mean PCT was 146.7±41.9 μm at baseline, and 106.5±24.2 μm at 12 months (P < 0.001). Mean PCT of the contralateral eyes was 129.8±42.6 μm at baseline and 124.6±39.7 μm at 12 months (P = 0.089). Mean SFCT of CRVO-affected eyes was 225.8±77.9 μm at baseline, and 199.4±66.6 μm at 12 months (P = 0.009). Mean SFCT of the contralateral eyes was 218.4±83.0 μm at baseline, and 208.4±78.1 μm at 12 months (P = 0.089). Δ PCT was -41.6±25.3 μm in the CRVO-affected eyes, and -5.2±5.8 μm in the contralateral eyes (P<0.001). % PCT was -24.9±14.0% in the CRVO-affected eyes, and -4.0±0.4% in the contralateral eyes (P = 0.001). Δ SFCT was -26.4±24.6 μm in the CRVO-affected eyes, and -9.5±16.7μm in the contralateral eyes (P = 0.016). % SFCT was -10.4±9.8% in the CRVO-affected eyes, and -3.4±6.4% in the contralateral eyes (P = 0.015). Among the various factors, BCVA at baseline (β = 0.797, P = 0.001) and % SFCT (β = 0.712, P = 0.001) were significantly associated with visual outcome at 12 months in the CRVO-affected eyes.<h4>Conclusion</h4>Both peripapillary and subfoveal choroidal thickness reduced significantly over 12 months in the CRVO-affected eyes, but not in the contralateral eyes. In addition, the absolute reduction amount and reduction ratio of PCT and SFCT were significantly greater in the CRVO-affected eyes than the contralateral eyes.
format	article
author	Hae Min Kang Jeong Hoon Choi Hyoung Jun Koh Sung Chul Lee
author_facet	Hae Min Kang Jeong Hoon Choi Hyoung Jun Koh Sung Chul Lee
author_sort	Hae Min Kang
title	Changes in peripapillary and subfoveal choroidal thickness in patients with central retinal vein occlusion.
title_short	Changes in peripapillary and subfoveal choroidal thickness in patients with central retinal vein occlusion.
title_full	Changes in peripapillary and subfoveal choroidal thickness in patients with central retinal vein occlusion.
title_fullStr	Changes in peripapillary and subfoveal choroidal thickness in patients with central retinal vein occlusion.
title_full_unstemmed	Changes in peripapillary and subfoveal choroidal thickness in patients with central retinal vein occlusion.
title_sort	changes in peripapillary and subfoveal choroidal thickness in patients with central retinal vein occlusion.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/3f393ec29ac349efb8d7ee4ae348b21e
work_keys_str_mv	AT haeminkang changesinperipapillaryandsubfovealchoroidalthicknessinpatientswithcentralretinalveinocclusion AT jeonghoonchoi changesinperipapillaryandsubfovealchoroidalthicknessinpatientswithcentralretinalveinocclusion AT hyoungjunkoh changesinperipapillaryandsubfovealchoroidalthicknessinpatientswithcentralretinalveinocclusion AT sungchullee changesinperipapillaryandsubfovealchoroidalthicknessinpatientswithcentralretinalveinocclusion
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Changes in peripapillary and subfoveal choroidal thickness in patients with central retinal vein occlusion.

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