HMMR antisense RNA 1, a novel long noncoding RNA, regulates the progression of basal-like breast cancer cells

Wei Liu, Jun Ma, Yong Cheng, Hongbo Zhang, Wengguang Luo, Hongyan Zhang Department of Radiation Oncology, Anhui Provincial Hospital, Hefei, People’s Republic of China Abstract: Recently, accumulating evidence has suggested that long noncoding RNAs (lncRNAs) play...

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Autores principales:	Liu W, Ma J, Cheng Y, Zhang H, Luo W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	basal-like breast cancers long non-coding RNA Hyaluronan Mediated Motility Receptor (HMMR) HMMR Antisense RNA 1 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/3f3a3238d8374be085885dcf2f21e17f
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spelling	oai:doaj.org-article:3f3a3238d8374be085885dcf2f21e17f2021-12-02T00:42:01ZHMMR antisense RNA 1, a novel long noncoding RNA, regulates the progression of basal-like breast cancer cells1179-1314https://doaj.org/article/3f3a3238d8374be085885dcf2f21e17f2016-11-01T00:00:00Zhttps://www.dovepress.com/hmmr-antisense-rna-1-a-novel-long-noncoding-rna-regulates-the-progress-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Wei Liu, Jun Ma, Yong Cheng, Hongbo Zhang, Wengguang Luo, Hongyan Zhang Department of Radiation Oncology, Anhui Provincial Hospital, Hefei, People’s Republic of China Abstract: Recently, accumulating evidence has suggested that long noncoding RNAs (lncRNAs) play crucial roles in carcinogenesis and cancer progression. Hyaluronan-mediated motility receptor (HMMR) is an essential cancer-related gene in basal-like breast cancer (BLBC). In our study, HMMR antisense RNA 1 (HMMR-AS1) was analyzed in BLBC patients through polymerase chain reaction analysis. Here, we found that the expression of HMMR was positively correlated with HMMR-AS1 (RP11-80G.1). When HMMR-AS1 (RP11-80G.1) was knocked down, the expression of HMMR markedly reduced. Furthermore, in MDA-MB-231 and MDA-MB-468 breast cancer cells, the proliferation and migration abilities were remarkably suppressed via knocking down HMMR-AS1 (RP11-80G.1) in vitro. The results showed that lncRNA HMMR-AS1 (RP11-80G.1) influenced the progression of BLBCs through regulating HMMR, suggesting that HMMR-AS1 (RP11-80G.1) could be regarded as a novel biomarker and therapeutic target in the treatment of BLBCs in future. Keywords: HMMR antisense RNA 1, long noncoding RNA, hyaluronan mediated motility receptor, HMMR, basal-like breast cancer cellsLiu WMa JCheng YZhang HLuo WZhang HDove Medical Pressarticlebasal-like breast cancerslong non-coding RNAHyaluronan Mediated Motility Receptor (HMMR)HMMR Antisense RNA 1Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 8, Pp 223-229 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	basal-like breast cancers long non-coding RNA Hyaluronan Mediated Motility Receptor (HMMR) HMMR Antisense RNA 1 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	basal-like breast cancers long non-coding RNA Hyaluronan Mediated Motility Receptor (HMMR) HMMR Antisense RNA 1 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Liu W Ma J Cheng Y Zhang H Luo W Zhang H HMMR antisense RNA 1, a novel long noncoding RNA, regulates the progression of basal-like breast cancer cells
description	Wei Liu, Jun Ma, Yong Cheng, Hongbo Zhang, Wengguang Luo, Hongyan Zhang Department of Radiation Oncology, Anhui Provincial Hospital, Hefei, People’s Republic of China Abstract: Recently, accumulating evidence has suggested that long noncoding RNAs (lncRNAs) play crucial roles in carcinogenesis and cancer progression. Hyaluronan-mediated motility receptor (HMMR) is an essential cancer-related gene in basal-like breast cancer (BLBC). In our study, HMMR antisense RNA 1 (HMMR-AS1) was analyzed in BLBC patients through polymerase chain reaction analysis. Here, we found that the expression of HMMR was positively correlated with HMMR-AS1 (RP11-80G.1). When HMMR-AS1 (RP11-80G.1) was knocked down, the expression of HMMR markedly reduced. Furthermore, in MDA-MB-231 and MDA-MB-468 breast cancer cells, the proliferation and migration abilities were remarkably suppressed via knocking down HMMR-AS1 (RP11-80G.1) in vitro. The results showed that lncRNA HMMR-AS1 (RP11-80G.1) influenced the progression of BLBCs through regulating HMMR, suggesting that HMMR-AS1 (RP11-80G.1) could be regarded as a novel biomarker and therapeutic target in the treatment of BLBCs in future. Keywords: HMMR antisense RNA 1, long noncoding RNA, hyaluronan mediated motility receptor, HMMR, basal-like breast cancer cells
format	article
author	Liu W Ma J Cheng Y Zhang H Luo W Zhang H
author_facet	Liu W Ma J Cheng Y Zhang H Luo W Zhang H
author_sort	Liu W
title	HMMR antisense RNA 1, a novel long noncoding RNA, regulates the progression of basal-like breast cancer cells
title_short	HMMR antisense RNA 1, a novel long noncoding RNA, regulates the progression of basal-like breast cancer cells
title_full	HMMR antisense RNA 1, a novel long noncoding RNA, regulates the progression of basal-like breast cancer cells
title_fullStr	HMMR antisense RNA 1, a novel long noncoding RNA, regulates the progression of basal-like breast cancer cells
title_full_unstemmed	HMMR antisense RNA 1, a novel long noncoding RNA, regulates the progression of basal-like breast cancer cells
title_sort	hmmr antisense rna 1, a novel long noncoding rna, regulates the progression of basal-like breast cancer cells
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/3f3a3238d8374be085885dcf2f21e17f
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HMMR antisense RNA 1, a novel long noncoding RNA, regulates the progression of basal-like breast cancer cells

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