Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy

Unlike canonical macroautophagy, alternative autophagy does not require the factors Atg5 and Atg7, but does require Ulk1. Here the authors show that phosphorylation of Ulk1 at Ser746 by RIPK3 is required for alternative autophagy initiation at the Golgi in response to genotoxic stress.

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Autores principales:	Satoru Torii, Hirofumi Yamaguchi, Akira Nakanishi, Satoko Arakawa, Shinya Honda, Kenta Moriwaki, Hiroyasu Nakano, Shigeomi Shimizu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3f3a5cabe5ec4005addc0c3f0c1db251
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spelling	oai:doaj.org-article:3f3a5cabe5ec4005addc0c3f0c1db2512021-12-02T14:40:38ZIdentification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy10.1038/s41467-020-15577-22041-1723https://doaj.org/article/3f3a5cabe5ec4005addc0c3f0c1db2512020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15577-2https://doaj.org/toc/2041-1723Unlike canonical macroautophagy, alternative autophagy does not require the factors Atg5 and Atg7, but does require Ulk1. Here the authors show that phosphorylation of Ulk1 at Ser746 by RIPK3 is required for alternative autophagy initiation at the Golgi in response to genotoxic stress.Satoru ToriiHirofumi YamaguchiAkira NakanishiSatoko ArakawaShinya HondaKenta MoriwakiHiroyasu NakanoShigeomi ShimizuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Satoru Torii Hirofumi Yamaguchi Akira Nakanishi Satoko Arakawa Shinya Honda Kenta Moriwaki Hiroyasu Nakano Shigeomi Shimizu Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy
description	Unlike canonical macroautophagy, alternative autophagy does not require the factors Atg5 and Atg7, but does require Ulk1. Here the authors show that phosphorylation of Ulk1 at Ser746 by RIPK3 is required for alternative autophagy initiation at the Golgi in response to genotoxic stress.
format	article
author	Satoru Torii Hirofumi Yamaguchi Akira Nakanishi Satoko Arakawa Shinya Honda Kenta Moriwaki Hiroyasu Nakano Shigeomi Shimizu
author_facet	Satoru Torii Hirofumi Yamaguchi Akira Nakanishi Satoko Arakawa Shinya Honda Kenta Moriwaki Hiroyasu Nakano Shigeomi Shimizu
author_sort	Satoru Torii
title	Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy
title_short	Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy
title_full	Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy
title_fullStr	Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy
title_full_unstemmed	Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy
title_sort	identification of a phosphorylation site on ulk1 required for genotoxic stress-induced alternative autophagy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3f3a5cabe5ec4005addc0c3f0c1db251
work_keys_str_mv	AT satorutorii identificationofaphosphorylationsiteonulk1requiredforgenotoxicstressinducedalternativeautophagy AT hirofumiyamaguchi identificationofaphosphorylationsiteonulk1requiredforgenotoxicstressinducedalternativeautophagy AT akiranakanishi identificationofaphosphorylationsiteonulk1requiredforgenotoxicstressinducedalternativeautophagy AT satokoarakawa identificationofaphosphorylationsiteonulk1requiredforgenotoxicstressinducedalternativeautophagy AT shinyahonda identificationofaphosphorylationsiteonulk1requiredforgenotoxicstressinducedalternativeautophagy AT kentamoriwaki identificationofaphosphorylationsiteonulk1requiredforgenotoxicstressinducedalternativeautophagy AT hiroyasunakano identificationofaphosphorylationsiteonulk1requiredforgenotoxicstressinducedalternativeautophagy AT shigeomishimizu identificationofaphosphorylationsiteonulk1requiredforgenotoxicstressinducedalternativeautophagy
_version_	1718390169595281408

Identification of a phosphorylation site on Ulk1 required for genotoxic stress-induced alternative autophagy

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