Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels

Clonal dynamics of Barrett’s esophagus (BE) leading to cancer are poorly understood. Here, they report BE segments are clonal, have frequent mutations at the gastro-esophageal junction, genomic instability precedes genome doubling/clonal expansion, and a correlation between inter- and intra-biopsy g...

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Autores principales:	Pierre Martinez, Diego Mallo, Thomas G. Paulson, Xiaohong Li, Carissa A. Sanchez, Brian J. Reid, Trevor A. Graham, Mary K. Kuhner, Carlo C. Maley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3f3cef910e5f438080a7e775be0b1883
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spelling	oai:doaj.org-article:3f3cef910e5f438080a7e775be0b18832021-12-02T17:33:00ZEvolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels10.1038/s41467-017-02621-x2041-1723https://doaj.org/article/3f3cef910e5f438080a7e775be0b18832018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02621-xhttps://doaj.org/toc/2041-1723Clonal dynamics of Barrett’s esophagus (BE) leading to cancer are poorly understood. Here, they report BE segments are clonal, have frequent mutations at the gastro-esophageal junction, genomic instability precedes genome doubling/clonal expansion, and a correlation between inter- and intra-biopsy genetic diversity.Pierre MartinezDiego MalloThomas G. PaulsonXiaohong LiCarissa A. SanchezBrian J. ReidTrevor A. GrahamMary K. KuhnerCarlo C. MaleyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pierre Martinez Diego Mallo Thomas G. Paulson Xiaohong Li Carissa A. Sanchez Brian J. Reid Trevor A. Graham Mary K. Kuhner Carlo C. Maley Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels
description	Clonal dynamics of Barrett’s esophagus (BE) leading to cancer are poorly understood. Here, they report BE segments are clonal, have frequent mutations at the gastro-esophageal junction, genomic instability precedes genome doubling/clonal expansion, and a correlation between inter- and intra-biopsy genetic diversity.
format	article
author	Pierre Martinez Diego Mallo Thomas G. Paulson Xiaohong Li Carissa A. Sanchez Brian J. Reid Trevor A. Graham Mary K. Kuhner Carlo C. Maley
author_facet	Pierre Martinez Diego Mallo Thomas G. Paulson Xiaohong Li Carissa A. Sanchez Brian J. Reid Trevor A. Graham Mary K. Kuhner Carlo C. Maley
author_sort	Pierre Martinez
title	Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels
title_short	Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels
title_full	Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels
title_fullStr	Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels
title_full_unstemmed	Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels
title_sort	evolution of barrett’s esophagus through space and time at single-crypt and whole-biopsy levels
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3f3cef910e5f438080a7e775be0b1883
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Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels

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