Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels

Evolution of Barrett’s esophagus through space and time at single-crypt and whole-biopsy levels

Clonal dynamics of Barrett’s esophagus (BE) leading to cancer are poorly understood. Here, they report BE segments are clonal, have frequent mutations at the gastro-esophageal junction, genomic instability precedes genome doubling/clonal expansion, and a correlation between inter- and intra-biopsy g...

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Autores principales: Pierre Martinez, Diego Mallo, Thomas G. Paulson, Xiaohong Li, Carissa A. Sanchez, Brian J. Reid, Trevor A. Graham, Mary K. Kuhner, Carlo C. Maley
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/3f3cef910e5f438080a7e775be0b1883
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