Potential adverse effects of nanoparticles on the reproductive system

Ruolan Wang,1 Bin Song,2 Junrong Wu,1 Yanli Zhang,1 Aijie Chen,1 Longquan Shao1,3 1Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; 2Guizhou Provincial People’s Hospital, Guiyang 550002, China; 3Guangdong Provincial Key Laboratory of Construction and Detection in Ti...

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Autores principales:	Wang R, Song B, Wu J, Zhang Y, Chen A, Shao LQ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	nanoparticle，toxicity，reproductive Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3f3f38b5385348159942c4579bd514ff
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spelling	oai:doaj.org-article:3f3f38b5385348159942c4579bd514ff2021-12-02T02:56:00ZPotential adverse effects of nanoparticles on the reproductive system1178-2013https://doaj.org/article/3f3f38b5385348159942c4579bd514ff2018-12-01T00:00:00Zhttps://www.dovepress.com/potential-adverse-effects-of-nanoparticles-on-the-reproductive-system-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ruolan Wang,1 Bin Song,2 Junrong Wu,1 Yanli Zhang,1 Aijie Chen,1 Longquan Shao1,3 1Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; 2Guizhou Provincial People’s Hospital, Guiyang 550002, China; 3Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Guangzhou 510515, China Abstract: With the vigorous development of nanometer-sized materials, nanoproducts are becoming widely used in all aspects of life. In medicine, nanoparticles (NPs) can be used as nanoscopic drug carriers and for nanoimaging technologies. Thus, substantial attention has been paid to the potential risks of NPs. Previous studies have shown that numerous types of NPs are able to pass certain biological barriers and exert toxic effects on crucial organs, such as the brain, liver, and kidney. Only recently, attention has been directed toward the reproductive toxicity of nanomaterials. NPs can pass through the blood–testis barrier, placental barrier, and epithelial barrier, which protect reproductive tissues, and then accumulate in reproductive organs. NP accumulation damages organs (testis, epididymis, ovary, and uterus) by destroying Sertoli cells, Leydig cells, and germ cells, causing reproductive organ dysfunction that adversely affects sperm quality, quantity, morphology, and motility or reduces the number of mature oocytes and disrupts primary and secondary follicular development. In addition, NPs can disrupt the levels of secreted hormones, causing changes in sexual behavior. However, the current review primarily examines toxicological phenomena. The molecular mechanisms involved in NP toxicity to the reproductive system are not fully understood, but possible mechanisms include oxidative stress, apoptosis, inflammation, and genotoxicity. Previous studies have shown that NPs can increase inflammation, oxidative stress, and apoptosis and induce ROS, causing damage at the molecular and genetic levels which results in cytotoxicity. This review provides an understanding of the applications and toxicological effects of NPs on the reproductive system. Keywords: nanoparticles, toxic, reproductive, sperm, ovary, ROSWang RSong BWu JZhang YChen AShao LQDove Medical Pressarticlenanoparticle，toxicity，reproductiveMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 8487-8506 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanoparticle，toxicity，reproductive Medicine (General) R5-920
spellingShingle	nanoparticle，toxicity，reproductive Medicine (General) R5-920 Wang R Song B Wu J Zhang Y Chen A Shao LQ Potential adverse effects of nanoparticles on the reproductive system
description	Ruolan Wang,1 Bin Song,2 Junrong Wu,1 Yanli Zhang,1 Aijie Chen,1 Longquan Shao1,3 1Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; 2Guizhou Provincial People’s Hospital, Guiyang 550002, China; 3Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Guangzhou 510515, China Abstract: With the vigorous development of nanometer-sized materials, nanoproducts are becoming widely used in all aspects of life. In medicine, nanoparticles (NPs) can be used as nanoscopic drug carriers and for nanoimaging technologies. Thus, substantial attention has been paid to the potential risks of NPs. Previous studies have shown that numerous types of NPs are able to pass certain biological barriers and exert toxic effects on crucial organs, such as the brain, liver, and kidney. Only recently, attention has been directed toward the reproductive toxicity of nanomaterials. NPs can pass through the blood–testis barrier, placental barrier, and epithelial barrier, which protect reproductive tissues, and then accumulate in reproductive organs. NP accumulation damages organs (testis, epididymis, ovary, and uterus) by destroying Sertoli cells, Leydig cells, and germ cells, causing reproductive organ dysfunction that adversely affects sperm quality, quantity, morphology, and motility or reduces the number of mature oocytes and disrupts primary and secondary follicular development. In addition, NPs can disrupt the levels of secreted hormones, causing changes in sexual behavior. However, the current review primarily examines toxicological phenomena. The molecular mechanisms involved in NP toxicity to the reproductive system are not fully understood, but possible mechanisms include oxidative stress, apoptosis, inflammation, and genotoxicity. Previous studies have shown that NPs can increase inflammation, oxidative stress, and apoptosis and induce ROS, causing damage at the molecular and genetic levels which results in cytotoxicity. This review provides an understanding of the applications and toxicological effects of NPs on the reproductive system. Keywords: nanoparticles, toxic, reproductive, sperm, ovary, ROS
format	article
author	Wang R Song B Wu J Zhang Y Chen A Shao LQ
author_facet	Wang R Song B Wu J Zhang Y Chen A Shao LQ
author_sort	Wang R
title	Potential adverse effects of nanoparticles on the reproductive system
title_short	Potential adverse effects of nanoparticles on the reproductive system
title_full	Potential adverse effects of nanoparticles on the reproductive system
title_fullStr	Potential adverse effects of nanoparticles on the reproductive system
title_full_unstemmed	Potential adverse effects of nanoparticles on the reproductive system
title_sort	potential adverse effects of nanoparticles on the reproductive system
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/3f3f38b5385348159942c4579bd514ff
work_keys_str_mv	AT wangr potentialadverseeffectsofnanoparticlesonthereproductivesystem AT songb potentialadverseeffectsofnanoparticlesonthereproductivesystem AT wuj potentialadverseeffectsofnanoparticlesonthereproductivesystem AT zhangy potentialadverseeffectsofnanoparticlesonthereproductivesystem AT chena potentialadverseeffectsofnanoparticlesonthereproductivesystem AT shaolq potentialadverseeffectsofnanoparticlesonthereproductivesystem
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Potential adverse effects of nanoparticles on the reproductive system

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