Exploring the evolution of novel enzyme functions within structurally defined protein superfamilies.

In order to understand the evolution of enzyme reactions and to gain an overview of biological catalysis we have combined sequence and structural data to generate phylogenetic trees in an analysis of 276 structurally defined enzyme superfamilies, and used these to study how enzyme functions have evo...

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Bibliographic Details
Main Authors: Nicholas Furnham, Ian Sillitoe, Gemma L Holliday, Alison L Cuff, Roman A Laskowski, Christine A Orengo, Janet M Thornton
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
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Online Access:https://doaj.org/article/3f40aaa07cb648a8bc60cdf2ba6ec48b
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