The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries

The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries

p140Cap adaptor proteins interfere with adhesion and growth factor-dependent signalling in cancer cells but the mechanisms are unclear. Here the authors show that p140Cap interferes with ERBB2-dependent activation of Rac GTPase-controlled circuitries reducing metastasis and cancer progression.

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Autores principales: Silvia Grasso, Jennifer Chapelle, Vincenzo Salemme, Simona Aramu, Isabella Russo, Nicoletta Vitale, Ludovica Verdun di Cantogno, Katiuscia Dallaglio, Isabella Castellano, Augusto Amici, Giorgia Centonze, Nanaocha Sharma, Serena Lunardi, Sara Cabodi, Federica Cavallo, Alessia Lamolinara, Lorenzo Stramucci, Enrico Moiso, Paolo Provero, Adriana Albini, Anna Sapino, Johan Staaf, Pier Paolo Di Fiore, Giovanni Bertalot, Salvatore Pece, Daniela Tosoni, Stefano Confalonieri, Manuela Iezzi, Paola Di Stefano, Emilia Turco, Paola Defilippi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/3f467620764d4f4e9419cd933a8e92a7
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spelling oai:doaj.org-article:3f467620764d4f4e9419cd933a8e92a72021-12-02T15:38:31ZThe scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries10.1038/ncomms147972041-1723https://doaj.org/article/3f467620764d4f4e9419cd933a8e92a72017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14797https://doaj.org/toc/2041-1723p140Cap adaptor proteins interfere with adhesion and growth factor-dependent signalling in cancer cells but the mechanisms are unclear. Here the authors show that p140Cap interferes with ERBB2-dependent activation of Rac GTPase-controlled circuitries reducing metastasis and cancer progression.Silvia GrassoJennifer ChapelleVincenzo SalemmeSimona AramuIsabella RussoNicoletta VitaleLudovica Verdun di CantognoKatiuscia DallaglioIsabella CastellanoAugusto AmiciGiorgia CentonzeNanaocha SharmaSerena LunardiSara CabodiFederica CavalloAlessia LamolinaraLorenzo StramucciEnrico MoisoPaolo ProveroAdriana AlbiniAnna SapinoJohan StaafPier Paolo Di FioreGiovanni BertalotSalvatore PeceDaniela TosoniStefano ConfalonieriManuela IezziPaola Di StefanoEmilia TurcoPaola DefilippiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Silvia Grasso
Jennifer Chapelle
Vincenzo Salemme
Simona Aramu
Isabella Russo
Nicoletta Vitale
Ludovica Verdun di Cantogno
Katiuscia Dallaglio
Isabella Castellano
Augusto Amici
Giorgia Centonze
Nanaocha Sharma
Serena Lunardi
Sara Cabodi
Federica Cavallo
Alessia Lamolinara
Lorenzo Stramucci
Enrico Moiso
Paolo Provero
Adriana Albini
Anna Sapino
Johan Staaf
Pier Paolo Di Fiore
Giovanni Bertalot
Salvatore Pece
Daniela Tosoni
Stefano Confalonieri
Manuela Iezzi
Paola Di Stefano
Emilia Turco
Paola Defilippi
The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries
description p140Cap adaptor proteins interfere with adhesion and growth factor-dependent signalling in cancer cells but the mechanisms are unclear. Here the authors show that p140Cap interferes with ERBB2-dependent activation of Rac GTPase-controlled circuitries reducing metastasis and cancer progression.
format article
author Silvia Grasso
Jennifer Chapelle
Vincenzo Salemme
Simona Aramu
Isabella Russo
Nicoletta Vitale
Ludovica Verdun di Cantogno
Katiuscia Dallaglio
Isabella Castellano
Augusto Amici
Giorgia Centonze
Nanaocha Sharma
Serena Lunardi
Sara Cabodi
Federica Cavallo
Alessia Lamolinara
Lorenzo Stramucci
Enrico Moiso
Paolo Provero
Adriana Albini
Anna Sapino
Johan Staaf
Pier Paolo Di Fiore
Giovanni Bertalot
Salvatore Pece
Daniela Tosoni
Stefano Confalonieri
Manuela Iezzi
Paola Di Stefano
Emilia Turco
Paola Defilippi
author_facet Silvia Grasso
Jennifer Chapelle
Vincenzo Salemme
Simona Aramu
Isabella Russo
Nicoletta Vitale
Ludovica Verdun di Cantogno
Katiuscia Dallaglio
Isabella Castellano
Augusto Amici
Giorgia Centonze
Nanaocha Sharma
Serena Lunardi
Sara Cabodi
Federica Cavallo
Alessia Lamolinara
Lorenzo Stramucci
Enrico Moiso
Paolo Provero
Adriana Albini
Anna Sapino
Johan Staaf
Pier Paolo Di Fiore
Giovanni Bertalot
Salvatore Pece
Daniela Tosoni
Stefano Confalonieri
Manuela Iezzi
Paola Di Stefano
Emilia Turco
Paola Defilippi
author_sort Silvia Grasso
title The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries
title_short The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries
title_full The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries
title_fullStr The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries
title_full_unstemmed The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries
title_sort scaffold protein p140cap limits erbb2-mediated breast cancer progression interfering with rac gtpase-controlled circuitries
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/3f467620764d4f4e9419cd933a8e92a7
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