Do Certain Flavonoid IMPS Have a Vital Function?

Flavonoids are a vast group of metabolites that are essential for vascular plant physiology and, thus, occur ubiquitously in plant-based/-derived foods. The solitary designation of thousands of known flavonoids hides the fact that their metabolomes are structurally highly diverse, consist of dispara...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	David S. Seigler, J. Brent Friesen, Jonathan Bisson, James G. Graham, Ana Bedran-Russo, James B. McAlpine, Guido F. Pauli
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	flavonoids Vitamin P Vitamin C invalid metabolic panaceas (IMPS) vitamins micronutrients Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/3f4686f1e932447daa29d3faee39f939
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3f4686f1e932447daa29d3faee39f939
record_format	dspace
spelling	oai:doaj.org-article:3f4686f1e932447daa29d3faee39f9392021-12-02T00:36:30ZDo Certain Flavonoid IMPS Have a Vital Function?2296-861X10.3389/fnut.2021.762753https://doaj.org/article/3f4686f1e932447daa29d3faee39f9392021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.762753/fullhttps://doaj.org/toc/2296-861XFlavonoids are a vast group of metabolites that are essential for vascular plant physiology and, thus, occur ubiquitously in plant-based/-derived foods. The solitary designation of thousands of known flavonoids hides the fact that their metabolomes are structurally highly diverse, consist of disparate subgroups, yet undergo a certain degree of metabolic interconversion. Unsurprisingly, flavonoids have been an important theme in nutrition research. Already in the 1930s, it was discovered that the ability of synthetic Vitamin C to treat scurvy was inferior to that of plant extracts containing Vitamin C. Subsequent experimental evidence led to the proposal of Vitamin P (permeability) as an essential phytochemical nutrient. However, attempts to isolate and characterize Vitamin P gave confusing and sometimes irreproducible results, which today can be interpreted as rooted in the unrecognized (residual) complexity of the intervention materials. Over the years, primarily flavonoids (and some coumarins) were known as having Vitamin P-like activity. More recently, in a NAPRALERT meta-analysis, essentially all of these Vitamin P candidates were identified as IMPs (Invalid/Improbable/Interfering Metabolic Panaceas). While the historic inability to define a single compound and specific mode of action led to general skepticism about the Vitamin P proposition for “bioflavonoids,” the more logical conclusion is that several abundant and metabolically labile plant constituents fill this essential role in human nutrition at the interface of vitamins, cofactors, and micronutrients. Reviewing 100+ years of the multilingual Vitamin P and C literature provides the rationales for this conclusion and new perspectives for future research.David S. SeiglerJ. Brent FriesenJ. Brent FriesenJ. Brent FriesenJ. Brent FriesenJonathan BissonJonathan BissonJonathan BissonJames G. GrahamJames G. GrahamJames G. GrahamAna Bedran-RussoAna Bedran-RussoJames B. McAlpineJames B. McAlpineJames B. McAlpineGuido F. PauliGuido F. PauliGuido F. PauliFrontiers Media S.A.articleflavonoidsVitamin PVitamin Cinvalid metabolic panaceas (IMPS)vitaminsmicronutrientsNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	flavonoids Vitamin P Vitamin C invalid metabolic panaceas (IMPS) vitamins micronutrients Nutrition. Foods and food supply TX341-641
spellingShingle	flavonoids Vitamin P Vitamin C invalid metabolic panaceas (IMPS) vitamins micronutrients Nutrition. Foods and food supply TX341-641 David S. Seigler J. Brent Friesen J. Brent Friesen J. Brent Friesen J. Brent Friesen Jonathan Bisson Jonathan Bisson Jonathan Bisson James G. Graham James G. Graham James G. Graham Ana Bedran-Russo Ana Bedran-Russo James B. McAlpine James B. McAlpine James B. McAlpine Guido F. Pauli Guido F. Pauli Guido F. Pauli Do Certain Flavonoid IMPS Have a Vital Function?
description	Flavonoids are a vast group of metabolites that are essential for vascular plant physiology and, thus, occur ubiquitously in plant-based/-derived foods. The solitary designation of thousands of known flavonoids hides the fact that their metabolomes are structurally highly diverse, consist of disparate subgroups, yet undergo a certain degree of metabolic interconversion. Unsurprisingly, flavonoids have been an important theme in nutrition research. Already in the 1930s, it was discovered that the ability of synthetic Vitamin C to treat scurvy was inferior to that of plant extracts containing Vitamin C. Subsequent experimental evidence led to the proposal of Vitamin P (permeability) as an essential phytochemical nutrient. However, attempts to isolate and characterize Vitamin P gave confusing and sometimes irreproducible results, which today can be interpreted as rooted in the unrecognized (residual) complexity of the intervention materials. Over the years, primarily flavonoids (and some coumarins) were known as having Vitamin P-like activity. More recently, in a NAPRALERT meta-analysis, essentially all of these Vitamin P candidates were identified as IMPs (Invalid/Improbable/Interfering Metabolic Panaceas). While the historic inability to define a single compound and specific mode of action led to general skepticism about the Vitamin P proposition for “bioflavonoids,” the more logical conclusion is that several abundant and metabolically labile plant constituents fill this essential role in human nutrition at the interface of vitamins, cofactors, and micronutrients. Reviewing 100+ years of the multilingual Vitamin P and C literature provides the rationales for this conclusion and new perspectives for future research.
format	article
author	David S. Seigler J. Brent Friesen J. Brent Friesen J. Brent Friesen J. Brent Friesen Jonathan Bisson Jonathan Bisson Jonathan Bisson James G. Graham James G. Graham James G. Graham Ana Bedran-Russo Ana Bedran-Russo James B. McAlpine James B. McAlpine James B. McAlpine Guido F. Pauli Guido F. Pauli Guido F. Pauli
author_facet	David S. Seigler J. Brent Friesen J. Brent Friesen J. Brent Friesen J. Brent Friesen Jonathan Bisson Jonathan Bisson Jonathan Bisson James G. Graham James G. Graham James G. Graham Ana Bedran-Russo Ana Bedran-Russo James B. McAlpine James B. McAlpine James B. McAlpine Guido F. Pauli Guido F. Pauli Guido F. Pauli
author_sort	David S. Seigler
title	Do Certain Flavonoid IMPS Have a Vital Function?
title_short	Do Certain Flavonoid IMPS Have a Vital Function?
title_full	Do Certain Flavonoid IMPS Have a Vital Function?
title_fullStr	Do Certain Flavonoid IMPS Have a Vital Function?
title_full_unstemmed	Do Certain Flavonoid IMPS Have a Vital Function?
title_sort	do certain flavonoid imps have a vital function?
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/3f4686f1e932447daa29d3faee39f939
work_keys_str_mv	AT davidsseigler docertainflavonoidimpshaveavitalfunction AT jbrentfriesen docertainflavonoidimpshaveavitalfunction AT jbrentfriesen docertainflavonoidimpshaveavitalfunction AT jbrentfriesen docertainflavonoidimpshaveavitalfunction AT jbrentfriesen docertainflavonoidimpshaveavitalfunction AT jonathanbisson docertainflavonoidimpshaveavitalfunction AT jonathanbisson docertainflavonoidimpshaveavitalfunction AT jonathanbisson docertainflavonoidimpshaveavitalfunction AT jamesggraham docertainflavonoidimpshaveavitalfunction AT jamesggraham docertainflavonoidimpshaveavitalfunction AT jamesggraham docertainflavonoidimpshaveavitalfunction AT anabedranrusso docertainflavonoidimpshaveavitalfunction AT anabedranrusso docertainflavonoidimpshaveavitalfunction AT jamesbmcalpine docertainflavonoidimpshaveavitalfunction AT jamesbmcalpine docertainflavonoidimpshaveavitalfunction AT jamesbmcalpine docertainflavonoidimpshaveavitalfunction AT guidofpauli docertainflavonoidimpshaveavitalfunction AT guidofpauli docertainflavonoidimpshaveavitalfunction AT guidofpauli docertainflavonoidimpshaveavitalfunction
_version_	1718403611254325248

Do Certain Flavonoid IMPS Have a Vital Function?

Ejemplares similares