Structure and mechanism of the human NHE1-CHP1 complex

Sodium/proton exchanger 1 (NHE1) and its obligate binding partner Calcineurin B-homologous protein 1 (CHP1) regulate intracellular pH and volume homeostasis. Structures of the human NHE1-CHP1 complex offer insight into the regulation of NHE1 pH-sensitivity by CHP1 and into the interactions with NHE1...

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Main Authors:	Yanli Dong, Yiwei Gao, Alina Ilie, DuSik Kim, Annie Boucher, Bin Li, Xuejun C. Zhang, John Orlowski, Yan Zhao
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/3f4c24b1d2414fd2bb2b6bbd97155253
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spelling	oai:doaj.org-article:3f4c24b1d2414fd2bb2b6bbd971552532021-12-02T17:52:37ZStructure and mechanism of the human NHE1-CHP1 complex10.1038/s41467-021-23496-z2041-1723https://doaj.org/article/3f4c24b1d2414fd2bb2b6bbd971552532021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23496-zhttps://doaj.org/toc/2041-1723Sodium/proton exchanger 1 (NHE1) and its obligate binding partner Calcineurin B-homologous protein 1 (CHP1) regulate intracellular pH and volume homeostasis. Structures of the human NHE1-CHP1 complex offer insight into the regulation of NHE1 pH-sensitivity by CHP1 and into the interactions with NHE1 inhibitors.Yanli DongYiwei GaoAlina IlieDuSik KimAnnie BoucherBin LiXuejun C. ZhangJohn OrlowskiYan ZhaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yanli Dong Yiwei Gao Alina Ilie DuSik Kim Annie Boucher Bin Li Xuejun C. Zhang John Orlowski Yan Zhao Structure and mechanism of the human NHE1-CHP1 complex
description	Sodium/proton exchanger 1 (NHE1) and its obligate binding partner Calcineurin B-homologous protein 1 (CHP1) regulate intracellular pH and volume homeostasis. Structures of the human NHE1-CHP1 complex offer insight into the regulation of NHE1 pH-sensitivity by CHP1 and into the interactions with NHE1 inhibitors.
format	article
author	Yanli Dong Yiwei Gao Alina Ilie DuSik Kim Annie Boucher Bin Li Xuejun C. Zhang John Orlowski Yan Zhao
author_facet	Yanli Dong Yiwei Gao Alina Ilie DuSik Kim Annie Boucher Bin Li Xuejun C. Zhang John Orlowski Yan Zhao
author_sort	Yanli Dong
title	Structure and mechanism of the human NHE1-CHP1 complex
title_short	Structure and mechanism of the human NHE1-CHP1 complex
title_full	Structure and mechanism of the human NHE1-CHP1 complex
title_fullStr	Structure and mechanism of the human NHE1-CHP1 complex
title_full_unstemmed	Structure and mechanism of the human NHE1-CHP1 complex
title_sort	structure and mechanism of the human nhe1-chp1 complex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3f4c24b1d2414fd2bb2b6bbd97155253
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Structure and mechanism of the human NHE1-CHP1 complex

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