Does swimming exercise affect experimental chronic kidney disease in rats treated with gum acacia?

Different modes of exercise are reported to be beneficial in subjects with chronic kidney disease (CKD). Similar benefits have also been ascribed to the dietary supplement gum acacia (GA). Using several physiological, biochemical, immunological, and histopathological measurements, we assessed the ef...

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Autores principales:	Badreldin H Ali, Suhail Al-Salam, Mohammed Al Za'abi, Khalid A Al Balushi, Aishwarya Ramkumar, Mostafa I Waly, Javid Yasin, Sirin A Adham, Abderrahim Nemmar
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3f4e16c84a444dd186ce144365530e2d
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spelling	oai:doaj.org-article:3f4e16c84a444dd186ce144365530e2d2021-11-25T06:07:44ZDoes swimming exercise affect experimental chronic kidney disease in rats treated with gum acacia?1932-620310.1371/journal.pone.0102528https://doaj.org/article/3f4e16c84a444dd186ce144365530e2d2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25048380/?tool=EBIhttps://doaj.org/toc/1932-6203Different modes of exercise are reported to be beneficial in subjects with chronic kidney disease (CKD). Similar benefits have also been ascribed to the dietary supplement gum acacia (GA). Using several physiological, biochemical, immunological, and histopathological measurements, we assessed the effect of swimming exercise (SE) on adenine-induced CKD, and tested whether SE would influence the salutary action of GA in rats with CKD. Eight groups of rats were used, the first four of which were fed normal chow for 5 weeks, feed mixed with adenine (0.25% w/w) to induce CKD, GA in the drinking water (15% w/v), or were given adenine plus GA, as above. Another four groups were similarly treated, but were subjected to SE during the experimental period, while the first four groups remained sedentary. The pre-SE program lasted for four days (before the start of the experimental treatments), during which the rats were made to swim for 5 to 10 min, and then gradually extended to 20 min per day. Thereafter, the rats in the 5th, 6th, 7th, and 8th groups started to receive their respective treatments, and were subjected to SE three days a week for 45 min each. Adenine induced the typical signs of CKD as confirmed by histopathology, and the other measurements, and GA significantly ameliorated all these signs. SE did not affect the salutary action of GA on renal histology, but it partially improved some of the above biochemical and physiological analytes, suggesting that addition of this mode of exercise to GA supplementation may improve further the benefits of GA supplementation.Badreldin H AliSuhail Al-SalamMohammed Al Za'abiKhalid A Al BalushiAishwarya RamkumarMostafa I WalyJavid YasinSirin A AdhamAbderrahim NemmarPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 7, p e102528 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Badreldin H Ali Suhail Al-Salam Mohammed Al Za'abi Khalid A Al Balushi Aishwarya Ramkumar Mostafa I Waly Javid Yasin Sirin A Adham Abderrahim Nemmar Does swimming exercise affect experimental chronic kidney disease in rats treated with gum acacia?
description	Different modes of exercise are reported to be beneficial in subjects with chronic kidney disease (CKD). Similar benefits have also been ascribed to the dietary supplement gum acacia (GA). Using several physiological, biochemical, immunological, and histopathological measurements, we assessed the effect of swimming exercise (SE) on adenine-induced CKD, and tested whether SE would influence the salutary action of GA in rats with CKD. Eight groups of rats were used, the first four of which were fed normal chow for 5 weeks, feed mixed with adenine (0.25% w/w) to induce CKD, GA in the drinking water (15% w/v), or were given adenine plus GA, as above. Another four groups were similarly treated, but were subjected to SE during the experimental period, while the first four groups remained sedentary. The pre-SE program lasted for four days (before the start of the experimental treatments), during which the rats were made to swim for 5 to 10 min, and then gradually extended to 20 min per day. Thereafter, the rats in the 5th, 6th, 7th, and 8th groups started to receive their respective treatments, and were subjected to SE three days a week for 45 min each. Adenine induced the typical signs of CKD as confirmed by histopathology, and the other measurements, and GA significantly ameliorated all these signs. SE did not affect the salutary action of GA on renal histology, but it partially improved some of the above biochemical and physiological analytes, suggesting that addition of this mode of exercise to GA supplementation may improve further the benefits of GA supplementation.
format	article
author	Badreldin H Ali Suhail Al-Salam Mohammed Al Za'abi Khalid A Al Balushi Aishwarya Ramkumar Mostafa I Waly Javid Yasin Sirin A Adham Abderrahim Nemmar
author_facet	Badreldin H Ali Suhail Al-Salam Mohammed Al Za'abi Khalid A Al Balushi Aishwarya Ramkumar Mostafa I Waly Javid Yasin Sirin A Adham Abderrahim Nemmar
author_sort	Badreldin H Ali
title	Does swimming exercise affect experimental chronic kidney disease in rats treated with gum acacia?
title_short	Does swimming exercise affect experimental chronic kidney disease in rats treated with gum acacia?
title_full	Does swimming exercise affect experimental chronic kidney disease in rats treated with gum acacia?
title_fullStr	Does swimming exercise affect experimental chronic kidney disease in rats treated with gum acacia?
title_full_unstemmed	Does swimming exercise affect experimental chronic kidney disease in rats treated with gum acacia?
title_sort	does swimming exercise affect experimental chronic kidney disease in rats treated with gum acacia?
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/3f4e16c84a444dd186ce144365530e2d
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Does swimming exercise affect experimental chronic kidney disease in rats treated with gum acacia?

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