Efficacy of Catheter Ablation for Atrial Arrhythmias in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy—A Multicenter Study
<b>Background:</b> Atrial arrhythmias are present in up to 20% of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). Catheter ablation (CA) is an effective treatment for atrial arrhythmias in the general population. Data regarding CA for atrial arrhythmias in ARVC are...
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oai:doaj.org-article:3f4edaafc7c1464cbc4537fc1787ff132021-11-11T17:35:45ZEfficacy of Catheter Ablation for Atrial Arrhythmias in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy—A Multicenter Study10.3390/jcm102149622077-0383https://doaj.org/article/3f4edaafc7c1464cbc4537fc1787ff132021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4962https://doaj.org/toc/2077-0383<b>Background:</b> Atrial arrhythmias are present in up to 20% of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). Catheter ablation (CA) is an effective treatment for atrial arrhythmias in the general population. Data regarding CA for atrial arrhythmias in ARVC are scarce. <b>Objective</b>: To assess the safety and efficacy of CA for atrial arrhythmias in patients with ARVC. <b>Methods:</b> In this international collaborative effort, all patients with a definite diagnosis of ARVC undergoing CA for atrial fibrillation (AF), focal atrial tachycardia (AT), or cavotricuspid isthmus (CTI)-dependent atrial flutter (AFl) were extracted from twelve ARVC registries. Demographic, periprocedural, and long-term arrhythmic outcome data were collected. <b>Results:</b> Thirty-seven patients were enrolled in the study (age 50.2 ± 16.6 years, male 84%, CHA<sub>2</sub>DS<sub>2</sub>VASc 1 (1,2), HAS-BLED 0 (0–2)). The arrhythmia leading to CA was AF in 23 (62%), focal left AT in 5 (14%), and CTI-dependent AFl in 9 (24%). Acute procedural success was achieved in all procedures but one (<i>n</i> = 1 focal left AT; 97% acute success). The median follow-up period was 27 (13–67) months, and 96%, 74%, and 61% of patients undergoing AF ablation were free from any atrial arrhythmia recurrence after a single procedure at 6 months, 12 months, and last follow-up, respectively. After focal AT ablation, freedom from atrial arrhythmia recurrence was 80%, 80%, and 60% at 6 months, 12 months, and last follow-up, respectively. All patients undergoing CTI ablation were free from atrial arrhythmia recurrences at 6 months, with 89% single-procedural arrhythmic freedom at last follow-up. One major complication (2.7%; PV stenosis requiring PV stenting) occurred. <b>Conclusions:</b> CA is safe and effective in managing atrial arrhythmias in patients with ARVC, with success rates comparable to the general population.Alessio GasperettiCynthia A. JamesLiang ChenNiklas SchenkerMichela CasellaShinwan KanyShibu MathewPaolo CompagnucciAndreas MüssigbrodtHenrik K. JensenAnneli SvenssonSarah CostaGiovanni B. ForleoPyotr G. PlatonovClaudio TondoJiang-Ping SongAntonio Dello RussoFrank RuschitzkaCorinna BrunckhorstHugh CalkinsFirat DuruArdan M. SagunerMDPI AGarticlearrhythmogenic right ventricular cardiomyopathyatrial fibrillationatrial flutterpulmonary vein isolationablation in special populationsMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4962, p 4962 (2021) |
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DOAJ |
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EN |
| topic |
arrhythmogenic right ventricular cardiomyopathy atrial fibrillation atrial flutter pulmonary vein isolation ablation in special populations Medicine R |
| spellingShingle |
arrhythmogenic right ventricular cardiomyopathy atrial fibrillation atrial flutter pulmonary vein isolation ablation in special populations Medicine R Alessio Gasperetti Cynthia A. James Liang Chen Niklas Schenker Michela Casella Shinwan Kany Shibu Mathew Paolo Compagnucci Andreas Müssigbrodt Henrik K. Jensen Anneli Svensson Sarah Costa Giovanni B. Forleo Pyotr G. Platonov Claudio Tondo Jiang-Ping Song Antonio Dello Russo Frank Ruschitzka Corinna Brunckhorst Hugh Calkins Firat Duru Ardan M. Saguner Efficacy of Catheter Ablation for Atrial Arrhythmias in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy—A Multicenter Study |
| description |
<b>Background:</b> Atrial arrhythmias are present in up to 20% of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). Catheter ablation (CA) is an effective treatment for atrial arrhythmias in the general population. Data regarding CA for atrial arrhythmias in ARVC are scarce. <b>Objective</b>: To assess the safety and efficacy of CA for atrial arrhythmias in patients with ARVC. <b>Methods:</b> In this international collaborative effort, all patients with a definite diagnosis of ARVC undergoing CA for atrial fibrillation (AF), focal atrial tachycardia (AT), or cavotricuspid isthmus (CTI)-dependent atrial flutter (AFl) were extracted from twelve ARVC registries. Demographic, periprocedural, and long-term arrhythmic outcome data were collected. <b>Results:</b> Thirty-seven patients were enrolled in the study (age 50.2 ± 16.6 years, male 84%, CHA<sub>2</sub>DS<sub>2</sub>VASc 1 (1,2), HAS-BLED 0 (0–2)). The arrhythmia leading to CA was AF in 23 (62%), focal left AT in 5 (14%), and CTI-dependent AFl in 9 (24%). Acute procedural success was achieved in all procedures but one (<i>n</i> = 1 focal left AT; 97% acute success). The median follow-up period was 27 (13–67) months, and 96%, 74%, and 61% of patients undergoing AF ablation were free from any atrial arrhythmia recurrence after a single procedure at 6 months, 12 months, and last follow-up, respectively. After focal AT ablation, freedom from atrial arrhythmia recurrence was 80%, 80%, and 60% at 6 months, 12 months, and last follow-up, respectively. All patients undergoing CTI ablation were free from atrial arrhythmia recurrences at 6 months, with 89% single-procedural arrhythmic freedom at last follow-up. One major complication (2.7%; PV stenosis requiring PV stenting) occurred. <b>Conclusions:</b> CA is safe and effective in managing atrial arrhythmias in patients with ARVC, with success rates comparable to the general population. |
| format |
article |
| author |
Alessio Gasperetti Cynthia A. James Liang Chen Niklas Schenker Michela Casella Shinwan Kany Shibu Mathew Paolo Compagnucci Andreas Müssigbrodt Henrik K. Jensen Anneli Svensson Sarah Costa Giovanni B. Forleo Pyotr G. Platonov Claudio Tondo Jiang-Ping Song Antonio Dello Russo Frank Ruschitzka Corinna Brunckhorst Hugh Calkins Firat Duru Ardan M. Saguner |
| author_facet |
Alessio Gasperetti Cynthia A. James Liang Chen Niklas Schenker Michela Casella Shinwan Kany Shibu Mathew Paolo Compagnucci Andreas Müssigbrodt Henrik K. Jensen Anneli Svensson Sarah Costa Giovanni B. Forleo Pyotr G. Platonov Claudio Tondo Jiang-Ping Song Antonio Dello Russo Frank Ruschitzka Corinna Brunckhorst Hugh Calkins Firat Duru Ardan M. Saguner |
| author_sort |
Alessio Gasperetti |
| title |
Efficacy of Catheter Ablation for Atrial Arrhythmias in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy—A Multicenter Study |
| title_short |
Efficacy of Catheter Ablation for Atrial Arrhythmias in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy—A Multicenter Study |
| title_full |
Efficacy of Catheter Ablation for Atrial Arrhythmias in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy—A Multicenter Study |
| title_fullStr |
Efficacy of Catheter Ablation for Atrial Arrhythmias in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy—A Multicenter Study |
| title_full_unstemmed |
Efficacy of Catheter Ablation for Atrial Arrhythmias in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy—A Multicenter Study |
| title_sort |
efficacy of catheter ablation for atrial arrhythmias in patients with arrhythmogenic right ventricular cardiomyopathy—a multicenter study |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/3f4edaafc7c1464cbc4537fc1787ff13 |
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