On the Origin of <named-content content-type="genus-species">Candida auris</named-content>: Ancestor, Environmental Stresses, and Antiseptics

ABSTRACT Candida auris has emerged as a serious threat to the health care settings. Advancements in molecular biology have provided several insights into the evolution of C. auris since it was first described in 2009. However, the simultaneous emergence of four different clades of the fungus at dist...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Megha Sharma, Arunaloke Chakrabarti
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	Candida auris emerging infection epidemiology evolution Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/3f4f64264007488fa34e2e6c0961e30d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3f4f64264007488fa34e2e6c0961e30d
record_format	dspace
spelling	oai:doaj.org-article:3f4f64264007488fa34e2e6c0961e30d2021-11-15T15:55:43ZOn the Origin of <named-content content-type="genus-species">Candida auris</named-content>: Ancestor, Environmental Stresses, and Antiseptics10.1128/mBio.02102-202150-7511https://doaj.org/article/3f4f64264007488fa34e2e6c0961e30d2020-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02102-20https://doaj.org/toc/2150-7511ABSTRACT Candida auris has emerged as a serious threat to the health care settings. Advancements in molecular biology have provided several insights into the evolution of C. auris since it was first described in 2009. However, the simultaneous emergence of four different clades of the fungus at distinct geographical locations remains a mystery. The hypotheses already proposed by researchers fall short of explaining how and why C. auris emerged. In this article, we theorize that C. auris emerged from a common ancestor, subsequently migrated to specific geographical locations, and diversified genetically. This hypothesis is supported by genomic insights, historical events, and indirect scientific facts. C. auris adapted to humans at locations and times coinciding with the divergence from the most recent common ancestor, emerging almost simultaneously as an opportunist pathogen due to antiseptic practices. Future research will support or refute this hypothesis.Megha SharmaArunaloke ChakrabartiAmerican Society for MicrobiologyarticleCandida aurisemerging infectionepidemiologyevolutionMicrobiologyQR1-502ENmBio, Vol 11, Iss 6 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Candida auris emerging infection epidemiology evolution Microbiology QR1-502
spellingShingle	Candida auris emerging infection epidemiology evolution Microbiology QR1-502 Megha Sharma Arunaloke Chakrabarti On the Origin of <named-content content-type="genus-species">Candida auris</named-content>: Ancestor, Environmental Stresses, and Antiseptics
description	ABSTRACT Candida auris has emerged as a serious threat to the health care settings. Advancements in molecular biology have provided several insights into the evolution of C. auris since it was first described in 2009. However, the simultaneous emergence of four different clades of the fungus at distinct geographical locations remains a mystery. The hypotheses already proposed by researchers fall short of explaining how and why C. auris emerged. In this article, we theorize that C. auris emerged from a common ancestor, subsequently migrated to specific geographical locations, and diversified genetically. This hypothesis is supported by genomic insights, historical events, and indirect scientific facts. C. auris adapted to humans at locations and times coinciding with the divergence from the most recent common ancestor, emerging almost simultaneously as an opportunist pathogen due to antiseptic practices. Future research will support or refute this hypothesis.
format	article
author	Megha Sharma Arunaloke Chakrabarti
author_facet	Megha Sharma Arunaloke Chakrabarti
author_sort	Megha Sharma
title	On the Origin of <named-content content-type="genus-species">Candida auris</named-content>: Ancestor, Environmental Stresses, and Antiseptics
title_short	On the Origin of <named-content content-type="genus-species">Candida auris</named-content>: Ancestor, Environmental Stresses, and Antiseptics
title_full	On the Origin of <named-content content-type="genus-species">Candida auris</named-content>: Ancestor, Environmental Stresses, and Antiseptics
title_fullStr	On the Origin of <named-content content-type="genus-species">Candida auris</named-content>: Ancestor, Environmental Stresses, and Antiseptics
title_full_unstemmed	On the Origin of <named-content content-type="genus-species">Candida auris</named-content>: Ancestor, Environmental Stresses, and Antiseptics
title_sort	on the origin of <named-content content-type="genus-species">candida auris</named-content>: ancestor, environmental stresses, and antiseptics
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/3f4f64264007488fa34e2e6c0961e30d
work_keys_str_mv	AT meghasharma ontheoriginofnamedcontentcontenttypegenusspeciescandidaaurisnamedcontentancestorenvironmentalstressesandantiseptics AT arunalokechakrabarti ontheoriginofnamedcontentcontenttypegenusspeciescandidaaurisnamedcontentancestorenvironmentalstressesandantiseptics
_version_	1718427145158524928

On the Origin of <named-content content-type="genus-species">Candida auris</named-content>: Ancestor, Environmental Stresses, and Antiseptics

Ejemplares similares