Genomic characterization of malignant progression in neoplastic pancreatic cysts

Neoplastic pancreatic cysts are associated with invasive pancreatic cancer, but their origins and evolutionary relationships are unclear. Here, the authors present the evolutionary analysis of neoplastic cysts and report them as precursors of invasive pancreatic cancer, and that SMAD4/TGFBR2 alterat...

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Autores principales:	Michaël Noë, Noushin Niknafs, Catherine G. Fischer, Wenzel M. Hackeng, Violeta Beleva Guthrie, Waki Hosoda, Marija Debeljak, Eniko Papp, Vilmos Adleff, James R. White, Claudio Luchini, Antonio Pea, Aldo Scarpa, Giovanni Butturini, Giuseppe Zamboni, Paola Castelli, Seung-Mo Hong, Shinichi Yachida, Nobuyoshi Hiraoka, Anthony J. Gill, Jaswinder S. Samra, G. Johan A. Offerhaus, Anne Hoorens, Joanne Verheij, Casper Jansen, N. Volkan Adsay, Wei Jiang, Jordan Winter, Jorge Albores-Saavedra, Benoit Terris, Elizabeth D. Thompson, Nicholas J. Roberts, Ralph H. Hruban, Rachel Karchin, Robert B. Scharpf, Lodewijk A. A. Brosens, Victor E. Velculescu, Laura D. Wood
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3f4f6cf36e134a3094f1e12eeacabd74
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spelling	oai:doaj.org-article:3f4f6cf36e134a3094f1e12eeacabd742021-12-02T16:27:51ZGenomic characterization of malignant progression in neoplastic pancreatic cysts10.1038/s41467-020-17917-82041-1723https://doaj.org/article/3f4f6cf36e134a3094f1e12eeacabd742020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17917-8https://doaj.org/toc/2041-1723Neoplastic pancreatic cysts are associated with invasive pancreatic cancer, but their origins and evolutionary relationships are unclear. Here, the authors present the evolutionary analysis of neoplastic cysts and report them as precursors of invasive pancreatic cancer, and that SMAD4/TGFBR2 alterations are likely drivers of invasion in a subset of cases.Michaël NoëNoushin NiknafsCatherine G. FischerWenzel M. HackengVioleta Beleva GuthrieWaki HosodaMarija DebeljakEniko PappVilmos AdleffJames R. WhiteClaudio LuchiniAntonio PeaAldo ScarpaGiovanni ButturiniGiuseppe ZamboniPaola CastelliSeung-Mo HongShinichi YachidaNobuyoshi HiraokaAnthony J. GillJaswinder S. SamraG. Johan A. OfferhausAnne HoorensJoanne VerheijCasper JansenN. Volkan AdsayWei JiangJordan WinterJorge Albores-SaavedraBenoit TerrisElizabeth D. ThompsonNicholas J. RobertsRalph H. HrubanRachel KarchinRobert B. ScharpfLodewijk A. A. BrosensVictor E. VelculescuLaura D. WoodNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michaël Noë Noushin Niknafs Catherine G. Fischer Wenzel M. Hackeng Violeta Beleva Guthrie Waki Hosoda Marija Debeljak Eniko Papp Vilmos Adleff James R. White Claudio Luchini Antonio Pea Aldo Scarpa Giovanni Butturini Giuseppe Zamboni Paola Castelli Seung-Mo Hong Shinichi Yachida Nobuyoshi Hiraoka Anthony J. Gill Jaswinder S. Samra G. Johan A. Offerhaus Anne Hoorens Joanne Verheij Casper Jansen N. Volkan Adsay Wei Jiang Jordan Winter Jorge Albores-Saavedra Benoit Terris Elizabeth D. Thompson Nicholas J. Roberts Ralph H. Hruban Rachel Karchin Robert B. Scharpf Lodewijk A. A. Brosens Victor E. Velculescu Laura D. Wood Genomic characterization of malignant progression in neoplastic pancreatic cysts
description	Neoplastic pancreatic cysts are associated with invasive pancreatic cancer, but their origins and evolutionary relationships are unclear. Here, the authors present the evolutionary analysis of neoplastic cysts and report them as precursors of invasive pancreatic cancer, and that SMAD4/TGFBR2 alterations are likely drivers of invasion in a subset of cases.
format	article
author	Michaël Noë Noushin Niknafs Catherine G. Fischer Wenzel M. Hackeng Violeta Beleva Guthrie Waki Hosoda Marija Debeljak Eniko Papp Vilmos Adleff James R. White Claudio Luchini Antonio Pea Aldo Scarpa Giovanni Butturini Giuseppe Zamboni Paola Castelli Seung-Mo Hong Shinichi Yachida Nobuyoshi Hiraoka Anthony J. Gill Jaswinder S. Samra G. Johan A. Offerhaus Anne Hoorens Joanne Verheij Casper Jansen N. Volkan Adsay Wei Jiang Jordan Winter Jorge Albores-Saavedra Benoit Terris Elizabeth D. Thompson Nicholas J. Roberts Ralph H. Hruban Rachel Karchin Robert B. Scharpf Lodewijk A. A. Brosens Victor E. Velculescu Laura D. Wood
author_facet	Michaël Noë Noushin Niknafs Catherine G. Fischer Wenzel M. Hackeng Violeta Beleva Guthrie Waki Hosoda Marija Debeljak Eniko Papp Vilmos Adleff James R. White Claudio Luchini Antonio Pea Aldo Scarpa Giovanni Butturini Giuseppe Zamboni Paola Castelli Seung-Mo Hong Shinichi Yachida Nobuyoshi Hiraoka Anthony J. Gill Jaswinder S. Samra G. Johan A. Offerhaus Anne Hoorens Joanne Verheij Casper Jansen N. Volkan Adsay Wei Jiang Jordan Winter Jorge Albores-Saavedra Benoit Terris Elizabeth D. Thompson Nicholas J. Roberts Ralph H. Hruban Rachel Karchin Robert B. Scharpf Lodewijk A. A. Brosens Victor E. Velculescu Laura D. Wood
author_sort	Michaël Noë
title	Genomic characterization of malignant progression in neoplastic pancreatic cysts
title_short	Genomic characterization of malignant progression in neoplastic pancreatic cysts
title_full	Genomic characterization of malignant progression in neoplastic pancreatic cysts
title_fullStr	Genomic characterization of malignant progression in neoplastic pancreatic cysts
title_full_unstemmed	Genomic characterization of malignant progression in neoplastic pancreatic cysts
title_sort	genomic characterization of malignant progression in neoplastic pancreatic cysts
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3f4f6cf36e134a3094f1e12eeacabd74
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Genomic characterization of malignant progression in neoplastic pancreatic cysts

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