Perinatal SSRI exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats

Abstract Selective serotonin reuptake inhibitors (SSRI), such as fluoxetine, are used as first-line antidepressant medication during pregnancy. Since SSRIs cross the placenta the unborn child is exposed to the maternal SSRI medication, resulting in, amongst others, increased risk for autism in offsp...

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Autores principales:	Noortje Van der Knaap, Dirk Wiedermann, Dirk Schubert, Mathias Hoehn, Judith R. Homberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3f50710e65f44b949ab474cfecf79cee
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spelling	oai:doaj.org-article:3f50710e65f44b949ab474cfecf79cee2021-12-02T13:50:49ZPerinatal SSRI exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats10.1038/s41598-021-81327-z2045-2322https://doaj.org/article/3f50710e65f44b949ab474cfecf79cee2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81327-zhttps://doaj.org/toc/2045-2322Abstract Selective serotonin reuptake inhibitors (SSRI), such as fluoxetine, are used as first-line antidepressant medication during pregnancy. Since SSRIs cross the placenta the unborn child is exposed to the maternal SSRI medication, resulting in, amongst others, increased risk for autism in offspring. This likely results from developmental changes in brain function. Studies employing rats lacking the serotonin transporter have shown that elevations in serotonin levels particularly affect the development of the whisker related part of the primary somatosensory (barrel) cortex. Therefore, we hypothesized that serotonin level disturbances during development alter brain activity related to whisker stimulation. We treated female dams with fluoxetine or vehicle from gestational day 11 onwards for 21 days. We investigated offspring’s brain activity during whisker stimulation using functional magnetic resonance imaging (fMRI) at adolescence and adulthood. Our results indicate that adolescent offspring displayed increased activity in hippocampal subareas and the mammillary body in the thalamus. Adult offspring exhibited increased functional activation of areas associated with (higher) sensory processing and memory such as the hippocampus, perirhinal and entorhinal cortex, retrospinal granular cortex, piriform cortex and secondary visual cortex. Our data imply that perinatal SSRI exposure leads to complex alterations in brain networks involved in sensory perception and processing.Noortje Van der KnaapDirk WiedermannDirk SchubertMathias HoehnJudith R. HombergNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Noortje Van der Knaap Dirk Wiedermann Dirk Schubert Mathias Hoehn Judith R. Homberg Perinatal SSRI exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats
description	Abstract Selective serotonin reuptake inhibitors (SSRI), such as fluoxetine, are used as first-line antidepressant medication during pregnancy. Since SSRIs cross the placenta the unborn child is exposed to the maternal SSRI medication, resulting in, amongst others, increased risk for autism in offspring. This likely results from developmental changes in brain function. Studies employing rats lacking the serotonin transporter have shown that elevations in serotonin levels particularly affect the development of the whisker related part of the primary somatosensory (barrel) cortex. Therefore, we hypothesized that serotonin level disturbances during development alter brain activity related to whisker stimulation. We treated female dams with fluoxetine or vehicle from gestational day 11 onwards for 21 days. We investigated offspring’s brain activity during whisker stimulation using functional magnetic resonance imaging (fMRI) at adolescence and adulthood. Our results indicate that adolescent offspring displayed increased activity in hippocampal subareas and the mammillary body in the thalamus. Adult offspring exhibited increased functional activation of areas associated with (higher) sensory processing and memory such as the hippocampus, perirhinal and entorhinal cortex, retrospinal granular cortex, piriform cortex and secondary visual cortex. Our data imply that perinatal SSRI exposure leads to complex alterations in brain networks involved in sensory perception and processing.
format	article
author	Noortje Van der Knaap Dirk Wiedermann Dirk Schubert Mathias Hoehn Judith R. Homberg
author_facet	Noortje Van der Knaap Dirk Wiedermann Dirk Schubert Mathias Hoehn Judith R. Homberg
author_sort	Noortje Van der Knaap
title	Perinatal SSRI exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats
title_short	Perinatal SSRI exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats
title_full	Perinatal SSRI exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats
title_fullStr	Perinatal SSRI exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats
title_full_unstemmed	Perinatal SSRI exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats
title_sort	perinatal ssri exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3f50710e65f44b949ab474cfecf79cee
work_keys_str_mv	AT noortjevanderknaap perinatalssriexposureaffectsbrainfunctionalactivityassociatedwithwhiskerstimulationinadolescentandadultrats AT dirkwiedermann perinatalssriexposureaffectsbrainfunctionalactivityassociatedwithwhiskerstimulationinadolescentandadultrats AT dirkschubert perinatalssriexposureaffectsbrainfunctionalactivityassociatedwithwhiskerstimulationinadolescentandadultrats AT mathiashoehn perinatalssriexposureaffectsbrainfunctionalactivityassociatedwithwhiskerstimulationinadolescentandadultrats AT judithrhomberg perinatalssriexposureaffectsbrainfunctionalactivityassociatedwithwhiskerstimulationinadolescentandadultrats
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Perinatal SSRI exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats

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