Leukocyte peroxidase and leptin: an associated link of glycemic tolerance and bronchial asthma?

Sergio ParcoImmunopathology Unit, Laboratory of the Department of Medicine, Children&rsquo;s Hospital, IRCCS Burlo Garofolo, Trieste, ItalyAbstract: Recent observations suggest the presence of an interaction between leptin and the inflammatory system during bronchial asthma. Although there i...

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Autor principal:	Sergio Parco
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/3f519fd5c9e342f792c212356b7226df
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spelling	oai:doaj.org-article:3f519fd5c9e342f792c212356b7226df2021-12-02T07:45:47ZLeukocyte peroxidase and leptin: an associated link of glycemic tolerance and bronchial asthma?1178-7007https://doaj.org/article/3f519fd5c9e342f792c212356b7226df2010-05-01T00:00:00Zhttp://www.dovepress.com/leukocyte-peroxidase-and-leptin-an-associated-link-of-glycemic-toleran-a4416https://doaj.org/toc/1178-7007Sergio ParcoImmunopathology Unit, Laboratory of the Department of Medicine, Children&rsquo;s Hospital, IRCCS Burlo Garofolo, Trieste, ItalyAbstract: Recent observations suggest the presence of an interaction between leptin and the inflammatory system during bronchial asthma. Although there is evidence of a positive association between asthma and obesity in adults and children, little is yet known about the role of serum leptin, as a potential mediator for bronchial epithelial homeostasis, and intraleukocyte myeloperoxidase (MPO), a hemoprotein with a molecular weight of 140 kDa, expression of the inflammatory system, in asthmatic children. Glycemic tolerance is an important pathogenetic element in developing type 2 mellitus diabetes and a confirmed predictor of incident asthma-like symptoms in adults. This work is aimed at assessing a possible correlation between basal leukocyte myeloperoxidase levels, basal leptin and insulin-glycemic tolerance in obese children. Thirty obese children aged between 7 and 15 years were examined. The analyzed data showed a normal response to the insulinemic stimulus in children of both sexes whose basal leptin and MPO values, expressed as MPO intracellular index, werewithin the normal range.Keywords: leptin, myeloperoxidase, glycemic tolerance, asthma Sergio ParcoDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2010, Iss default, Pp 113-116 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Sergio Parco Leukocyte peroxidase and leptin: an associated link of glycemic tolerance and bronchial asthma?
description	Sergio ParcoImmunopathology Unit, Laboratory of the Department of Medicine, Children&rsquo;s Hospital, IRCCS Burlo Garofolo, Trieste, ItalyAbstract: Recent observations suggest the presence of an interaction between leptin and the inflammatory system during bronchial asthma. Although there is evidence of a positive association between asthma and obesity in adults and children, little is yet known about the role of serum leptin, as a potential mediator for bronchial epithelial homeostasis, and intraleukocyte myeloperoxidase (MPO), a hemoprotein with a molecular weight of 140 kDa, expression of the inflammatory system, in asthmatic children. Glycemic tolerance is an important pathogenetic element in developing type 2 mellitus diabetes and a confirmed predictor of incident asthma-like symptoms in adults. This work is aimed at assessing a possible correlation between basal leukocyte myeloperoxidase levels, basal leptin and insulin-glycemic tolerance in obese children. Thirty obese children aged between 7 and 15 years were examined. The analyzed data showed a normal response to the insulinemic stimulus in children of both sexes whose basal leptin and MPO values, expressed as MPO intracellular index, werewithin the normal range.Keywords: leptin, myeloperoxidase, glycemic tolerance, asthma
format	article
author	Sergio Parco
author_facet	Sergio Parco
author_sort	Sergio Parco
title	Leukocyte peroxidase and leptin: an associated link of glycemic tolerance and bronchial asthma?
title_short	Leukocyte peroxidase and leptin: an associated link of glycemic tolerance and bronchial asthma?
title_full	Leukocyte peroxidase and leptin: an associated link of glycemic tolerance and bronchial asthma?
title_fullStr	Leukocyte peroxidase and leptin: an associated link of glycemic tolerance and bronchial asthma?
title_full_unstemmed	Leukocyte peroxidase and leptin: an associated link of glycemic tolerance and bronchial asthma?
title_sort	leukocyte peroxidase and leptin: an associated link of glycemic tolerance and bronchial asthma?
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/3f519fd5c9e342f792c212356b7226df
work_keys_str_mv	AT sergioparco leukocyteperoxidaseandleptinanassociatedlinkofglycemictoleranceandbronchialasthma
_version_	1718399217344446464

Leukocyte peroxidase and leptin: an associated link of glycemic tolerance and bronchial asthma?

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