A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61

Varicella-zoster virus (VZV) establishes lifelong infection in the majority of the population, but mechanisms underlying latency remain unclear. Here, the authors use ultra-deep RNA sequencing, enriched for viral RNAs, of latently infected human trigeminal ganglia and identify a spliced, latency-ass...

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Autores principales:	Daniel P. Depledge, Werner J. D. Ouwendijk, Tomohiko Sadaoka, Shirley E. Braspenning, Yasuko Mori, Randall J. Cohrs, Georges M. G. M. Verjans, Judith Breuer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3f51ee80bfab464b894f8be32f3866ef
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spelling	oai:doaj.org-article:3f51ee80bfab464b894f8be32f3866ef2021-12-02T16:49:52ZA spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 6110.1038/s41467-018-03569-22041-1723https://doaj.org/article/3f51ee80bfab464b894f8be32f3866ef2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03569-2https://doaj.org/toc/2041-1723Varicella-zoster virus (VZV) establishes lifelong infection in the majority of the population, but mechanisms underlying latency remain unclear. Here, the authors use ultra-deep RNA sequencing, enriched for viral RNAs, of latently infected human trigeminal ganglia and identify a spliced, latency-associated VZV mRNA.Daniel P. DepledgeWerner J. D. OuwendijkTomohiko SadaokaShirley E. BraspenningYasuko MoriRandall J. CohrsGeorges M. G. M. VerjansJudith BreuerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel P. Depledge Werner J. D. Ouwendijk Tomohiko Sadaoka Shirley E. Braspenning Yasuko Mori Randall J. Cohrs Georges M. G. M. Verjans Judith Breuer A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61
description	Varicella-zoster virus (VZV) establishes lifelong infection in the majority of the population, but mechanisms underlying latency remain unclear. Here, the authors use ultra-deep RNA sequencing, enriched for viral RNAs, of latently infected human trigeminal ganglia and identify a spliced, latency-associated VZV mRNA.
format	article
author	Daniel P. Depledge Werner J. D. Ouwendijk Tomohiko Sadaoka Shirley E. Braspenning Yasuko Mori Randall J. Cohrs Georges M. G. M. Verjans Judith Breuer
author_facet	Daniel P. Depledge Werner J. D. Ouwendijk Tomohiko Sadaoka Shirley E. Braspenning Yasuko Mori Randall J. Cohrs Georges M. G. M. Verjans Judith Breuer
author_sort	Daniel P. Depledge
title	A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61
title_short	A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61
title_full	A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61
title_fullStr	A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61
title_full_unstemmed	A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61
title_sort	spliced latency-associated vzv transcript maps antisense to the viral transactivator gene 61
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3f51ee80bfab464b894f8be32f3866ef
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A spliced latency-associated VZV transcript maps antisense to the viral transactivator gene 61

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