Diagnosing point-of-care diagnostics for neglected tropical diseases.

Inadequate and nonintegrated diagnostics are the Achilles' heel of global efforts to monitor, control, and eradicate neglected tropical diseases (NTDs). While treatment is often available, NTDs are endemic among marginalized populations, due to the unavailability or inadequacy of diagnostic tes...

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Autores principales:	Mitasha Bharadwaj, Michel Bengtson, Mirte Golverdingen, Loulotte Waling, Cees Dekker
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/3f56eb3b735a4d8b87f6ace33c678c6f
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spelling	oai:doaj.org-article:3f56eb3b735a4d8b87f6ace33c678c6f2021-11-25T06:31:46ZDiagnosing point-of-care diagnostics for neglected tropical diseases.1935-27271935-273510.1371/journal.pntd.0009405https://doaj.org/article/3f56eb3b735a4d8b87f6ace33c678c6f2021-06-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009405https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735Inadequate and nonintegrated diagnostics are the Achilles' heel of global efforts to monitor, control, and eradicate neglected tropical diseases (NTDs). While treatment is often available, NTDs are endemic among marginalized populations, due to the unavailability or inadequacy of diagnostic tests that cause empirical misdiagnoses. The need of the hour is early diagnosis at the point-of-care (PoC) of NTD patients. Here, we review the status quo of PoC diagnostic tests and practices for all of the 24 NTDs identified in the World Health Organization's (WHO) 2021-2030 roadmap, based on their different diagnostic requirements. We discuss the capabilities and shortcomings of current diagnostic tests, identify diagnostic needs, and formulate prerequisites of relevant PoC tests. Next to technical requirements, we stress the importance of availability and awareness programs for establishing PoC tests that fit endemic resource-limited settings. Better understanding of NTD diagnostics will pave the path for setting realistic goals for healthcare in areas with minimal resources, thereby alleviating the global healthcare burden.Mitasha BharadwajMichel BengtsonMirte GolverdingenLoulotte WalingCees DekkerPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 6, p e0009405 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Mitasha Bharadwaj Michel Bengtson Mirte Golverdingen Loulotte Waling Cees Dekker Diagnosing point-of-care diagnostics for neglected tropical diseases.
description	Inadequate and nonintegrated diagnostics are the Achilles' heel of global efforts to monitor, control, and eradicate neglected tropical diseases (NTDs). While treatment is often available, NTDs are endemic among marginalized populations, due to the unavailability or inadequacy of diagnostic tests that cause empirical misdiagnoses. The need of the hour is early diagnosis at the point-of-care (PoC) of NTD patients. Here, we review the status quo of PoC diagnostic tests and practices for all of the 24 NTDs identified in the World Health Organization's (WHO) 2021-2030 roadmap, based on their different diagnostic requirements. We discuss the capabilities and shortcomings of current diagnostic tests, identify diagnostic needs, and formulate prerequisites of relevant PoC tests. Next to technical requirements, we stress the importance of availability and awareness programs for establishing PoC tests that fit endemic resource-limited settings. Better understanding of NTD diagnostics will pave the path for setting realistic goals for healthcare in areas with minimal resources, thereby alleviating the global healthcare burden.
format	article
author	Mitasha Bharadwaj Michel Bengtson Mirte Golverdingen Loulotte Waling Cees Dekker
author_facet	Mitasha Bharadwaj Michel Bengtson Mirte Golverdingen Loulotte Waling Cees Dekker
author_sort	Mitasha Bharadwaj
title	Diagnosing point-of-care diagnostics for neglected tropical diseases.
title_short	Diagnosing point-of-care diagnostics for neglected tropical diseases.
title_full	Diagnosing point-of-care diagnostics for neglected tropical diseases.
title_fullStr	Diagnosing point-of-care diagnostics for neglected tropical diseases.
title_full_unstemmed	Diagnosing point-of-care diagnostics for neglected tropical diseases.
title_sort	diagnosing point-of-care diagnostics for neglected tropical diseases.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/3f56eb3b735a4d8b87f6ace33c678c6f
work_keys_str_mv	AT mitashabharadwaj diagnosingpointofcarediagnosticsforneglectedtropicaldiseases AT michelbengtson diagnosingpointofcarediagnosticsforneglectedtropicaldiseases AT mirtegolverdingen diagnosingpointofcarediagnosticsforneglectedtropicaldiseases AT loulottewaling diagnosingpointofcarediagnosticsforneglectedtropicaldiseases AT ceesdekker diagnosingpointofcarediagnosticsforneglectedtropicaldiseases
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Diagnosing point-of-care diagnostics for neglected tropical diseases.

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