Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma

Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma

The driver mutations for the two main molecular subgroups of diffuse large B-cell lymphoma (DLBCL) are poorly defined. Here, an integrative genomics analysis identifies 3′ UTR NFKBIZ mutations within the activated B-cell DLBCL subgroup and small FCGR2B amplifications in the germinal centre B-cell DL...

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Autores principales: Sarah E. Arthur, Aixiang Jiang, Bruno M. Grande, Miguel Alcaide, Razvan Cojocaru, Christopher K. Rushton, Anja Mottok, Laura K. Hilton, Prince Kumar Lat, Eric Y. Zhao, Luka Culibrk, Daisuke Ennishi, Selin Jessa, Lauren Chong, Nicole Thomas, Prasath Pararajalingam, Barbara Meissner, Merrill Boyle, Jordan Davidson, Kevin R. Bushell, Daniel Lai, Pedro Farinha, Graham W. Slack, Gregg B. Morin, Sohrab Shah, Dipankar Sen, Steven J. M. Jones, Andrew J. Mungall, Randy D. Gascoyne, Timothy E. Audas, Peter Unrau, Marco A. Marra, Joseph M. Connors, Christian Steidl, David W. Scott, Ryan D. Morin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/3f5730acbfb542c08d8c3ac5e60f9653
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spelling oai:doaj.org-article:3f5730acbfb542c08d8c3ac5e60f96532021-12-02T16:49:23ZGenome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma10.1038/s41467-018-06354-32041-1723https://doaj.org/article/3f5730acbfb542c08d8c3ac5e60f96532018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06354-3https://doaj.org/toc/2041-1723The driver mutations for the two main molecular subgroups of diffuse large B-cell lymphoma (DLBCL) are poorly defined. Here, an integrative genomics analysis identifies 3′ UTR NFKBIZ mutations within the activated B-cell DLBCL subgroup and small FCGR2B amplifications in the germinal centre B-cell DLBCL subgroup.Sarah E. ArthurAixiang JiangBruno M. GrandeMiguel AlcaideRazvan CojocaruChristopher K. RushtonAnja MottokLaura K. HiltonPrince Kumar LatEric Y. ZhaoLuka CulibrkDaisuke EnnishiSelin JessaLauren ChongNicole ThomasPrasath PararajalingamBarbara MeissnerMerrill BoyleJordan DavidsonKevin R. BushellDaniel LaiPedro FarinhaGraham W. SlackGregg B. MorinSohrab ShahDipankar SenSteven J. M. JonesAndrew J. MungallRandy D. GascoyneTimothy E. AudasPeter UnrauMarco A. MarraJoseph M. ConnorsChristian SteidlDavid W. ScottRyan D. MorinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sarah E. Arthur
Aixiang Jiang
Bruno M. Grande
Miguel Alcaide
Razvan Cojocaru
Christopher K. Rushton
Anja Mottok
Laura K. Hilton
Prince Kumar Lat
Eric Y. Zhao
Luka Culibrk
Daisuke Ennishi
Selin Jessa
Lauren Chong
Nicole Thomas
Prasath Pararajalingam
Barbara Meissner
Merrill Boyle
Jordan Davidson
Kevin R. Bushell
Daniel Lai
Pedro Farinha
Graham W. Slack
Gregg B. Morin
Sohrab Shah
Dipankar Sen
Steven J. M. Jones
Andrew J. Mungall
Randy D. Gascoyne
Timothy E. Audas
Peter Unrau
Marco A. Marra
Joseph M. Connors
Christian Steidl
David W. Scott
Ryan D. Morin
Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma
description The driver mutations for the two main molecular subgroups of diffuse large B-cell lymphoma (DLBCL) are poorly defined. Here, an integrative genomics analysis identifies 3′ UTR NFKBIZ mutations within the activated B-cell DLBCL subgroup and small FCGR2B amplifications in the germinal centre B-cell DLBCL subgroup.
format article
author Sarah E. Arthur
Aixiang Jiang
Bruno M. Grande
Miguel Alcaide
Razvan Cojocaru
Christopher K. Rushton
Anja Mottok
Laura K. Hilton
Prince Kumar Lat
Eric Y. Zhao
Luka Culibrk
Daisuke Ennishi
Selin Jessa
Lauren Chong
Nicole Thomas
Prasath Pararajalingam
Barbara Meissner
Merrill Boyle
Jordan Davidson
Kevin R. Bushell
Daniel Lai
Pedro Farinha
Graham W. Slack
Gregg B. Morin
Sohrab Shah
Dipankar Sen
Steven J. M. Jones
Andrew J. Mungall
Randy D. Gascoyne
Timothy E. Audas
Peter Unrau
Marco A. Marra
Joseph M. Connors
Christian Steidl
David W. Scott
Ryan D. Morin
author_facet Sarah E. Arthur
Aixiang Jiang
Bruno M. Grande
Miguel Alcaide
Razvan Cojocaru
Christopher K. Rushton
Anja Mottok
Laura K. Hilton
Prince Kumar Lat
Eric Y. Zhao
Luka Culibrk
Daisuke Ennishi
Selin Jessa
Lauren Chong
Nicole Thomas
Prasath Pararajalingam
Barbara Meissner
Merrill Boyle
Jordan Davidson
Kevin R. Bushell
Daniel Lai
Pedro Farinha
Graham W. Slack
Gregg B. Morin
Sohrab Shah
Dipankar Sen
Steven J. M. Jones
Andrew J. Mungall
Randy D. Gascoyne
Timothy E. Audas
Peter Unrau
Marco A. Marra
Joseph M. Connors
Christian Steidl
David W. Scott
Ryan D. Morin
author_sort Sarah E. Arthur
title Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma
title_short Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma
title_full Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma
title_fullStr Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma
title_full_unstemmed Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma
title_sort genome-wide discovery of somatic regulatory variants in diffuse large b-cell lymphoma
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/3f5730acbfb542c08d8c3ac5e60f9653
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