Comparison of pancreatic fat content measured by different methods employing MR mDixon sequence.

<h4>Objective</h4>To compare the reliability of different methods for measuring fat content of pancreas by MR modified Dixon(mDixon) Sequence and accurately evaluate pancreatic fat in as simple a way as possible.<h4>Methods</h4>This is a retrospective study, 64 patients were...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xiaoyang Li, Qiushi Yang, Hang Ye, Shuo Li, Yuzhu Wang, Wanjiang Yu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3f57fa976796457e9c348a69757f2422
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3f57fa976796457e9c348a69757f2422
record_format	dspace
spelling	oai:doaj.org-article:3f57fa976796457e9c348a69757f24222021-12-02T20:16:18ZComparison of pancreatic fat content measured by different methods employing MR mDixon sequence.1932-620310.1371/journal.pone.0260001https://doaj.org/article/3f57fa976796457e9c348a69757f24222021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0260001https://doaj.org/toc/1932-6203<h4>Objective</h4>To compare the reliability of different methods for measuring fat content of pancreas by MR modified Dixon(mDixon) Sequence and accurately evaluate pancreatic fat in as simple a way as possible.<h4>Methods</h4>This is a retrospective study, 64 patients were included in this study who underwent abdominal MR scan that contained the mDixon sequence from June 2019 to May 2020(Included 7 patients with type 2 diabetes and 4 patients with impaired glucose tolerance (IGT), they were admitted to hospital through the obesity clinic set up by endocrine department, all of them were initially diagnosed and untreated). All of the 64 patients were scanned in 3.0T MR (Philips Ingenia II) due to their condition, 10-34 slice pancreas images were obtained, which were different from each other. Three different methods of measurement were employed by two observers using Philips Intellispace Portal software: (1) All images (whole-pancreas) measurement, the whole-pancreatic fat fraction (wPFF) was calculated by software. (2) Interval slices measurement, that is half-pancreatic slices fat fraction (hPFF) measured in the same way, fat fraction obtained by the interlayer assay was calculated. (3) As usual, the fat content of pancreatic head, body and tail fat was measured respectively, and in order to improve credibility, we also measured head、 body and tail in every layer, and its average value was taken. The elapsed time of the above different measurement methods was recorded. Intra-group correlation coefficient (ICC) was used to analyze the consistency of the measured data within and between observers. T-tests and Friedman tests were applied to compare the difference of measured values among groups.<h4>Results</h4>No matter in normal person or diabetic or IGT, hPFF has shown good stability (ICChPFF = 0.988), and there was no significant difference compared with wPFF. But the average fat percentage composition of head, body and tail were significantly different from wPFF and hPFF (P < 0.01). At the same time, compared with normal person, pancreatic fat content in IGT and diabetic patients showed progressive significance(P<0.05).<h4>Conclusion</h4>The distribution of pancreatic fat is not uniform, the method of measuring half pancreas by interlayer data collection can reflect the fat content of the entire pancreas, this suggests that measuring 50% of the pancreas is sufficient, this method effectively saves time and effort without affecting the results, which may have a better clinical application prospect.Xiaoyang LiQiushi YangHang YeShuo LiYuzhu WangWanjiang YuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0260001 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaoyang Li Qiushi Yang Hang Ye Shuo Li Yuzhu Wang Wanjiang Yu Comparison of pancreatic fat content measured by different methods employing MR mDixon sequence.
description	<h4>Objective</h4>To compare the reliability of different methods for measuring fat content of pancreas by MR modified Dixon(mDixon) Sequence and accurately evaluate pancreatic fat in as simple a way as possible.<h4>Methods</h4>This is a retrospective study, 64 patients were included in this study who underwent abdominal MR scan that contained the mDixon sequence from June 2019 to May 2020(Included 7 patients with type 2 diabetes and 4 patients with impaired glucose tolerance (IGT), they were admitted to hospital through the obesity clinic set up by endocrine department, all of them were initially diagnosed and untreated). All of the 64 patients were scanned in 3.0T MR (Philips Ingenia II) due to their condition, 10-34 slice pancreas images were obtained, which were different from each other. Three different methods of measurement were employed by two observers using Philips Intellispace Portal software: (1) All images (whole-pancreas) measurement, the whole-pancreatic fat fraction (wPFF) was calculated by software. (2) Interval slices measurement, that is half-pancreatic slices fat fraction (hPFF) measured in the same way, fat fraction obtained by the interlayer assay was calculated. (3) As usual, the fat content of pancreatic head, body and tail fat was measured respectively, and in order to improve credibility, we also measured head、 body and tail in every layer, and its average value was taken. The elapsed time of the above different measurement methods was recorded. Intra-group correlation coefficient (ICC) was used to analyze the consistency of the measured data within and between observers. T-tests and Friedman tests were applied to compare the difference of measured values among groups.<h4>Results</h4>No matter in normal person or diabetic or IGT, hPFF has shown good stability (ICChPFF = 0.988), and there was no significant difference compared with wPFF. But the average fat percentage composition of head, body and tail were significantly different from wPFF and hPFF (P < 0.01). At the same time, compared with normal person, pancreatic fat content in IGT and diabetic patients showed progressive significance(P<0.05).<h4>Conclusion</h4>The distribution of pancreatic fat is not uniform, the method of measuring half pancreas by interlayer data collection can reflect the fat content of the entire pancreas, this suggests that measuring 50% of the pancreas is sufficient, this method effectively saves time and effort without affecting the results, which may have a better clinical application prospect.
format	article
author	Xiaoyang Li Qiushi Yang Hang Ye Shuo Li Yuzhu Wang Wanjiang Yu
author_facet	Xiaoyang Li Qiushi Yang Hang Ye Shuo Li Yuzhu Wang Wanjiang Yu
author_sort	Xiaoyang Li
title	Comparison of pancreatic fat content measured by different methods employing MR mDixon sequence.
title_short	Comparison of pancreatic fat content measured by different methods employing MR mDixon sequence.
title_full	Comparison of pancreatic fat content measured by different methods employing MR mDixon sequence.
title_fullStr	Comparison of pancreatic fat content measured by different methods employing MR mDixon sequence.
title_full_unstemmed	Comparison of pancreatic fat content measured by different methods employing MR mDixon sequence.
title_sort	comparison of pancreatic fat content measured by different methods employing mr mdixon sequence.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/3f57fa976796457e9c348a69757f2422
work_keys_str_mv	AT xiaoyangli comparisonofpancreaticfatcontentmeasuredbydifferentmethodsemployingmrmdixonsequence AT qiushiyang comparisonofpancreaticfatcontentmeasuredbydifferentmethodsemployingmrmdixonsequence AT hangye comparisonofpancreaticfatcontentmeasuredbydifferentmethodsemployingmrmdixonsequence AT shuoli comparisonofpancreaticfatcontentmeasuredbydifferentmethodsemployingmrmdixonsequence AT yuzhuwang comparisonofpancreaticfatcontentmeasuredbydifferentmethodsemployingmrmdixonsequence AT wanjiangyu comparisonofpancreaticfatcontentmeasuredbydifferentmethodsemployingmrmdixonsequence
_version_	1718374520441536512

Comparison of pancreatic fat content measured by different methods employing MR mDixon sequence.

Ejemplares similares