Nonsurgical Options for the Treatment of Basal Cell Carcinoma

Objectives: The aim of this review article is to summarize the effectiveness, potential adverse events, and indications of the main nonsurgical treatment alternatives for basal cell carcinoma. Methods: An extensive literature review was carried out. The most relevant articles were discussed and...

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Autores principales: John Paoli, Johan Dahlén Gyllencreutz, Julia Fougelberg, Eva Johansson Backman, Maja Modin, Sam Polesie, Oscar Zaar
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Lenguaje:EN
Publicado: Mattioli1885 2019
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Acceso en línea:https://doaj.org/article/3f590b7d9f67481cbd30dd651b8b9cda
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spelling oai:doaj.org-article:3f590b7d9f67481cbd30dd651b8b9cda2021-11-17T08:29:33ZNonsurgical Options for the Treatment of Basal Cell Carcinoma10.5826/dpc.0902a012160-9381https://doaj.org/article/3f590b7d9f67481cbd30dd651b8b9cda2019-04-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/604https://doaj.org/toc/2160-9381 Objectives: The aim of this review article is to summarize the effectiveness, potential adverse events, and indications of the main nonsurgical treatment alternatives for basal cell carcinoma. Methods: An extensive literature review was carried out. The most relevant articles were discussed and selected by the authors in order to provide a brief but evidence-based overview of the most common nonsurgical methods used for treating basal cell carcinoma. Results: Although surgery and Mohs micrographic surgery are often considered the optimal treatment options for basal cell carcinoma, these tumors can also be treated successfully with destructive techniques (eg, curettage alone, cryosurgery, or electrodesiccation), photodynamic therapy, topical drugs (eg, 5-fluorouracil, imiquimod, or ingenol mebutate), radiotherapy, or hedgehog pathway inhibitors. When choosing between these alternatives, physicians must take into consideration the tumor’s size, location, and histopathological subtype. Special care should be taken when treating recurrent tumors. Furthermore, physician experience is of great importance when using destructive techniques. Finally, patient preference, potential adverse events, and cosmetic outcome should also be considered. Conclusions: Dermatologists and physicians treating basal cell carcinoma should have knowledge of and experience with the large arsenal of therapeutic alternatives available for the successful, safe, and individualized management of patients with basal cell carcinoma. John PaoliJohan Dahlén GyllencreutzJulia FougelbergEva Johansson BackmanMaja ModinSam PolesieOscar ZaarMattioli1885articlebasal cell carcinomadestructive therapytopical drugsradiotherapyhedgehog inhibitorsDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 9, Iss 2 (2019)
institution DOAJ
collection DOAJ
language EN
topic basal cell carcinoma
destructive therapy
topical drugs
radiotherapy
hedgehog inhibitors
Dermatology
RL1-803
spellingShingle basal cell carcinoma
destructive therapy
topical drugs
radiotherapy
hedgehog inhibitors
Dermatology
RL1-803
John Paoli
Johan Dahlén Gyllencreutz
Julia Fougelberg
Eva Johansson Backman
Maja Modin
Sam Polesie
Oscar Zaar
Nonsurgical Options for the Treatment of Basal Cell Carcinoma
description Objectives: The aim of this review article is to summarize the effectiveness, potential adverse events, and indications of the main nonsurgical treatment alternatives for basal cell carcinoma. Methods: An extensive literature review was carried out. The most relevant articles were discussed and selected by the authors in order to provide a brief but evidence-based overview of the most common nonsurgical methods used for treating basal cell carcinoma. Results: Although surgery and Mohs micrographic surgery are often considered the optimal treatment options for basal cell carcinoma, these tumors can also be treated successfully with destructive techniques (eg, curettage alone, cryosurgery, or electrodesiccation), photodynamic therapy, topical drugs (eg, 5-fluorouracil, imiquimod, or ingenol mebutate), radiotherapy, or hedgehog pathway inhibitors. When choosing between these alternatives, physicians must take into consideration the tumor’s size, location, and histopathological subtype. Special care should be taken when treating recurrent tumors. Furthermore, physician experience is of great importance when using destructive techniques. Finally, patient preference, potential adverse events, and cosmetic outcome should also be considered. Conclusions: Dermatologists and physicians treating basal cell carcinoma should have knowledge of and experience with the large arsenal of therapeutic alternatives available for the successful, safe, and individualized management of patients with basal cell carcinoma.
format article
author John Paoli
Johan Dahlén Gyllencreutz
Julia Fougelberg
Eva Johansson Backman
Maja Modin
Sam Polesie
Oscar Zaar
author_facet John Paoli
Johan Dahlén Gyllencreutz
Julia Fougelberg
Eva Johansson Backman
Maja Modin
Sam Polesie
Oscar Zaar
author_sort John Paoli
title Nonsurgical Options for the Treatment of Basal Cell Carcinoma
title_short Nonsurgical Options for the Treatment of Basal Cell Carcinoma
title_full Nonsurgical Options for the Treatment of Basal Cell Carcinoma
title_fullStr Nonsurgical Options for the Treatment of Basal Cell Carcinoma
title_full_unstemmed Nonsurgical Options for the Treatment of Basal Cell Carcinoma
title_sort nonsurgical options for the treatment of basal cell carcinoma
publisher Mattioli1885
publishDate 2019
url https://doaj.org/article/3f590b7d9f67481cbd30dd651b8b9cda
work_keys_str_mv AT johnpaoli nonsurgicaloptionsforthetreatmentofbasalcellcarcinoma
AT johandahlengyllencreutz nonsurgicaloptionsforthetreatmentofbasalcellcarcinoma
AT juliafougelberg nonsurgicaloptionsforthetreatmentofbasalcellcarcinoma
AT evajohanssonbackman nonsurgicaloptionsforthetreatmentofbasalcellcarcinoma
AT majamodin nonsurgicaloptionsforthetreatmentofbasalcellcarcinoma
AT sampolesie nonsurgicaloptionsforthetreatmentofbasalcellcarcinoma
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