Nonsurgical Options for the Treatment of Basal Cell Carcinoma

Objectives: The aim of this review article is to summarize the effectiveness, potential adverse events, and indications of the main nonsurgical treatment alternatives for basal cell carcinoma. Methods: An extensive literature review was carried out. The most relevant articles were discussed and...

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Autores principales:	John Paoli, Johan Dahlén Gyllencreutz, Julia Fougelberg, Eva Johansson Backman, Maja Modin, Sam Polesie, Oscar Zaar
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2019
Materias:	basal cell carcinoma destructive therapy topical drugs radiotherapy hedgehog inhibitors Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/3f590b7d9f67481cbd30dd651b8b9cda
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spelling	oai:doaj.org-article:3f590b7d9f67481cbd30dd651b8b9cda2021-11-17T08:29:33ZNonsurgical Options for the Treatment of Basal Cell Carcinoma10.5826/dpc.0902a012160-9381https://doaj.org/article/3f590b7d9f67481cbd30dd651b8b9cda2019-04-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/604https://doaj.org/toc/2160-9381 Objectives: The aim of this review article is to summarize the effectiveness, potential adverse events, and indications of the main nonsurgical treatment alternatives for basal cell carcinoma. Methods: An extensive literature review was carried out. The most relevant articles were discussed and selected by the authors in order to provide a brief but evidence-based overview of the most common nonsurgical methods used for treating basal cell carcinoma. Results: Although surgery and Mohs micrographic surgery are often considered the optimal treatment options for basal cell carcinoma, these tumors can also be treated successfully with destructive techniques (eg, curettage alone, cryosurgery, or electrodesiccation), photodynamic therapy, topical drugs (eg, 5-fluorouracil, imiquimod, or ingenol mebutate), radiotherapy, or hedgehog pathway inhibitors. When choosing between these alternatives, physicians must take into consideration the tumor’s size, location, and histopathological subtype. Special care should be taken when treating recurrent tumors. Furthermore, physician experience is of great importance when using destructive techniques. Finally, patient preference, potential adverse events, and cosmetic outcome should also be considered. Conclusions: Dermatologists and physicians treating basal cell carcinoma should have knowledge of and experience with the large arsenal of therapeutic alternatives available for the successful, safe, and individualized management of patients with basal cell carcinoma. John PaoliJohan Dahlén GyllencreutzJulia FougelbergEva Johansson BackmanMaja ModinSam PolesieOscar ZaarMattioli1885articlebasal cell carcinomadestructive therapytopical drugsradiotherapyhedgehog inhibitorsDermatologyRL1-803ENDermatology Practical & Conceptual, Vol 9, Iss 2 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	basal cell carcinoma destructive therapy topical drugs radiotherapy hedgehog inhibitors Dermatology RL1-803
spellingShingle	basal cell carcinoma destructive therapy topical drugs radiotherapy hedgehog inhibitors Dermatology RL1-803 John Paoli Johan Dahlén Gyllencreutz Julia Fougelberg Eva Johansson Backman Maja Modin Sam Polesie Oscar Zaar Nonsurgical Options for the Treatment of Basal Cell Carcinoma
description	Objectives: The aim of this review article is to summarize the effectiveness, potential adverse events, and indications of the main nonsurgical treatment alternatives for basal cell carcinoma. Methods: An extensive literature review was carried out. The most relevant articles were discussed and selected by the authors in order to provide a brief but evidence-based overview of the most common nonsurgical methods used for treating basal cell carcinoma. Results: Although surgery and Mohs micrographic surgery are often considered the optimal treatment options for basal cell carcinoma, these tumors can also be treated successfully with destructive techniques (eg, curettage alone, cryosurgery, or electrodesiccation), photodynamic therapy, topical drugs (eg, 5-fluorouracil, imiquimod, or ingenol mebutate), radiotherapy, or hedgehog pathway inhibitors. When choosing between these alternatives, physicians must take into consideration the tumor’s size, location, and histopathological subtype. Special care should be taken when treating recurrent tumors. Furthermore, physician experience is of great importance when using destructive techniques. Finally, patient preference, potential adverse events, and cosmetic outcome should also be considered. Conclusions: Dermatologists and physicians treating basal cell carcinoma should have knowledge of and experience with the large arsenal of therapeutic alternatives available for the successful, safe, and individualized management of patients with basal cell carcinoma.
format	article
author	John Paoli Johan Dahlén Gyllencreutz Julia Fougelberg Eva Johansson Backman Maja Modin Sam Polesie Oscar Zaar
author_facet	John Paoli Johan Dahlén Gyllencreutz Julia Fougelberg Eva Johansson Backman Maja Modin Sam Polesie Oscar Zaar
author_sort	John Paoli
title	Nonsurgical Options for the Treatment of Basal Cell Carcinoma
title_short	Nonsurgical Options for the Treatment of Basal Cell Carcinoma
title_full	Nonsurgical Options for the Treatment of Basal Cell Carcinoma
title_fullStr	Nonsurgical Options for the Treatment of Basal Cell Carcinoma
title_full_unstemmed	Nonsurgical Options for the Treatment of Basal Cell Carcinoma
title_sort	nonsurgical options for the treatment of basal cell carcinoma
publisher	Mattioli1885
publishDate	2019
url	https://doaj.org/article/3f590b7d9f67481cbd30dd651b8b9cda
work_keys_str_mv	AT johnpaoli nonsurgicaloptionsforthetreatmentofbasalcellcarcinoma AT johandahlengyllencreutz nonsurgicaloptionsforthetreatmentofbasalcellcarcinoma AT juliafougelberg nonsurgicaloptionsforthetreatmentofbasalcellcarcinoma AT evajohanssonbackman nonsurgicaloptionsforthetreatmentofbasalcellcarcinoma AT majamodin nonsurgicaloptionsforthetreatmentofbasalcellcarcinoma AT sampolesie nonsurgicaloptionsforthetreatmentofbasalcellcarcinoma AT oscarzaar nonsurgicaloptionsforthetreatmentofbasalcellcarcinoma
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Nonsurgical Options for the Treatment of Basal Cell Carcinoma

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