Resolving kinetic intermediates during the regulated assembly and disassembly of fusion pores

SNAREs mediate the formation of a fusion pore during exocytosis which connects the lumen of a vesicle with the extracellular space. Here, authors use single molecule approaches to define the role of synaptotagmin 1 and NSF in synaptic pore formation and dissolution.

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Bibliographic Details
Main Authors: Debasis Das, Huan Bao, Kevin C. Courtney, Lanxi Wu, Edwin R. Chapman
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/3f5a1f5773cd4fc6a794f2fc8bf7582b
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Summary:SNAREs mediate the formation of a fusion pore during exocytosis which connects the lumen of a vesicle with the extracellular space. Here, authors use single molecule approaches to define the role of synaptotagmin 1 and NSF in synaptic pore formation and dissolution.