Dynamic changes of scleral spur length in different accommodation stimuli states

Abstract This study aimed to evaluate the scleral spur length (SSL) in response to different accommodation stimuli states, as well as the correlation with Schlemm’s canal (SC) and trabecular meshwork (TM). 74 children were recruited for this study. The 0D, − 4D, and − 8.0 D accommodation stimuli sta...

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Auteurs principaux:	Liugui Chen, Wei Jin, Xinlei Hao, Xuejie Li, Yiqiao Xing
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Medicine R Science Q
Accès en ligne:	https://doaj.org/article/3f5b17f350d84b4fa5a0682e1649c7e0
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spelling	oai:doaj.org-article:3f5b17f350d84b4fa5a0682e1649c7e02021-12-02T15:31:27ZDynamic changes of scleral spur length in different accommodation stimuli states10.1038/s41598-021-97754-x2045-2322https://doaj.org/article/3f5b17f350d84b4fa5a0682e1649c7e02021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97754-xhttps://doaj.org/toc/2045-2322Abstract This study aimed to evaluate the scleral spur length (SSL) in response to different accommodation stimuli states, as well as the correlation with Schlemm’s canal (SC) and trabecular meshwork (TM). 74 children were recruited for this study. The 0D, − 4D, and − 8.0 D accommodation stimuli state was achieved by looking at a variable distance optotype. The ciliary muscle (CM), scleral spur (SS), SC, and TM were imaged by swept-source optical coherence tomography. The SSL (Method III) increased significantly from 221.56 ± 30.74 μm at base state to 234.99 ± 30.11 μm at − 4D accommodation stimuli state (p = 0.028) and increased to 250.09 ± 29.87 μm at − 8D accommodation stimuli state (p = 0.011). Method III had the largest areas under receiver operating characteristic (ROC) curves (0.798, 95% CI 0.721–0.875). Moreover, CM 1, SC, and trabecular meshwork length (TML) were significantly correlated with SSL (Method III) (p < 0.05). These findings suggest that the contractile ability and compliance of the SS play an important role in maintaining the morphology of the SC. Moreover, the force of accommodation regulates the SC size by increasing the length of SS.Liugui ChenWei JinXinlei HaoXuejie LiYiqiao XingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Liugui Chen Wei Jin Xinlei Hao Xuejie Li Yiqiao Xing Dynamic changes of scleral spur length in different accommodation stimuli states
description	Abstract This study aimed to evaluate the scleral spur length (SSL) in response to different accommodation stimuli states, as well as the correlation with Schlemm’s canal (SC) and trabecular meshwork (TM). 74 children were recruited for this study. The 0D, − 4D, and − 8.0 D accommodation stimuli state was achieved by looking at a variable distance optotype. The ciliary muscle (CM), scleral spur (SS), SC, and TM were imaged by swept-source optical coherence tomography. The SSL (Method III) increased significantly from 221.56 ± 30.74 μm at base state to 234.99 ± 30.11 μm at − 4D accommodation stimuli state (p = 0.028) and increased to 250.09 ± 29.87 μm at − 8D accommodation stimuli state (p = 0.011). Method III had the largest areas under receiver operating characteristic (ROC) curves (0.798, 95% CI 0.721–0.875). Moreover, CM 1, SC, and trabecular meshwork length (TML) were significantly correlated with SSL (Method III) (p < 0.05). These findings suggest that the contractile ability and compliance of the SS play an important role in maintaining the morphology of the SC. Moreover, the force of accommodation regulates the SC size by increasing the length of SS.
format	article
author	Liugui Chen Wei Jin Xinlei Hao Xuejie Li Yiqiao Xing
author_facet	Liugui Chen Wei Jin Xinlei Hao Xuejie Li Yiqiao Xing
author_sort	Liugui Chen
title	Dynamic changes of scleral spur length in different accommodation stimuli states
title_short	Dynamic changes of scleral spur length in different accommodation stimuli states
title_full	Dynamic changes of scleral spur length in different accommodation stimuli states
title_fullStr	Dynamic changes of scleral spur length in different accommodation stimuli states
title_full_unstemmed	Dynamic changes of scleral spur length in different accommodation stimuli states
title_sort	dynamic changes of scleral spur length in different accommodation stimuli states
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3f5b17f350d84b4fa5a0682e1649c7e0
work_keys_str_mv	AT liuguichen dynamicchangesofscleralspurlengthindifferentaccommodationstimulistates AT weijin dynamicchangesofscleralspurlengthindifferentaccommodationstimulistates AT xinleihao dynamicchangesofscleralspurlengthindifferentaccommodationstimulistates AT xuejieli dynamicchangesofscleralspurlengthindifferentaccommodationstimulistates AT yiqiaoxing dynamicchangesofscleralspurlengthindifferentaccommodationstimulistates
_version_	1718387137529774080

Dynamic changes of scleral spur length in different accommodation stimuli states

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