Non-ketogenic combination of nutritional strategies provides robust protection against seizures

Abstract Epilepsy is a neurological condition that affects 1% of the world population. Conventional treatments of epilepsy use drugs targeting neuronal excitability, inhibitory or excitatory transmission. Yet, one third of patients presents an intractable form of epilepsy and fails to respond to pha...

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Autores principales:	Glenn Dallérac, Julien Moulard, Jean-François Benoist, Stefan Rouach, Stéphane Auvin, Angèle Guilbot, Loïc Lenoir, Nathalie Rouach
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3f5bb815ae8d486b8919ce065ebb45d8
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spelling	oai:doaj.org-article:3f5bb815ae8d486b8919ce065ebb45d82021-12-02T16:06:18ZNon-ketogenic combination of nutritional strategies provides robust protection against seizures10.1038/s41598-017-05542-32045-2322https://doaj.org/article/3f5bb815ae8d486b8919ce065ebb45d82017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05542-3https://doaj.org/toc/2045-2322Abstract Epilepsy is a neurological condition that affects 1% of the world population. Conventional treatments of epilepsy use drugs targeting neuronal excitability, inhibitory or excitatory transmission. Yet, one third of patients presents an intractable form of epilepsy and fails to respond to pharmacological anti-epileptic strategies. The ketogenic diet is a well-established non-pharmacological treatment that has been proven to be effective in reducing seizure frequency in the pharmaco-resistant patients. This dietary solution is however extremely restrictive and can be associated with complications caused by the high [fat]:[carbohydrate + protein] ratio. Recent advances suggest that the traditional 4:1 ratio of the ketogenic diet is not a requisite for its therapeutic effect. We show here that combining nutritional strategies targeting specific amino-acids, carbohydrates and fatty acids with a low [fat]:[proteins + carbohydrates] ratio also reduces excitatory drive and protects against seizures to the same extent as the ketogenic diet. Similarly, the morphological and molecular correlates of temporal lobe seizures were reduced in animals fed with the combined diet. These results provide evidence that low-fat dietary strategies more palatable than the ketogenic diet could be useful in epilepsy.Glenn DalléracJulien MoulardJean-François BenoistStefan RouachStéphane AuvinAngèle GuilbotLoïc LenoirNathalie RouachNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Glenn Dallérac Julien Moulard Jean-François Benoist Stefan Rouach Stéphane Auvin Angèle Guilbot Loïc Lenoir Nathalie Rouach Non-ketogenic combination of nutritional strategies provides robust protection against seizures
description	Abstract Epilepsy is a neurological condition that affects 1% of the world population. Conventional treatments of epilepsy use drugs targeting neuronal excitability, inhibitory or excitatory transmission. Yet, one third of patients presents an intractable form of epilepsy and fails to respond to pharmacological anti-epileptic strategies. The ketogenic diet is a well-established non-pharmacological treatment that has been proven to be effective in reducing seizure frequency in the pharmaco-resistant patients. This dietary solution is however extremely restrictive and can be associated with complications caused by the high [fat]:[carbohydrate + protein] ratio. Recent advances suggest that the traditional 4:1 ratio of the ketogenic diet is not a requisite for its therapeutic effect. We show here that combining nutritional strategies targeting specific amino-acids, carbohydrates and fatty acids with a low [fat]:[proteins + carbohydrates] ratio also reduces excitatory drive and protects against seizures to the same extent as the ketogenic diet. Similarly, the morphological and molecular correlates of temporal lobe seizures were reduced in animals fed with the combined diet. These results provide evidence that low-fat dietary strategies more palatable than the ketogenic diet could be useful in epilepsy.
format	article
author	Glenn Dallérac Julien Moulard Jean-François Benoist Stefan Rouach Stéphane Auvin Angèle Guilbot Loïc Lenoir Nathalie Rouach
author_facet	Glenn Dallérac Julien Moulard Jean-François Benoist Stefan Rouach Stéphane Auvin Angèle Guilbot Loïc Lenoir Nathalie Rouach
author_sort	Glenn Dallérac
title	Non-ketogenic combination of nutritional strategies provides robust protection against seizures
title_short	Non-ketogenic combination of nutritional strategies provides robust protection against seizures
title_full	Non-ketogenic combination of nutritional strategies provides robust protection against seizures
title_fullStr	Non-ketogenic combination of nutritional strategies provides robust protection against seizures
title_full_unstemmed	Non-ketogenic combination of nutritional strategies provides robust protection against seizures
title_sort	non-ketogenic combination of nutritional strategies provides robust protection against seizures
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3f5bb815ae8d486b8919ce065ebb45d8
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Non-ketogenic combination of nutritional strategies provides robust protection against seizures

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