One of the possible mechanisms of glucose absorption slowing during immobilization stress

An experimental study was performed on outbred male rats. In the first series of chronic experiments we studied the process of glucose absorption in an isolated loop of a jejunum in 12 rats. In the second series we studied the changes of lipid peroxidation during immobilization with the introduction...

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Autores principales:	L. I. Korytov, L. A. Grebyonkina, M. I. Suslikova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	2-этил-6-метил-3-оксипиридина сукцинат stress lipid peroxidation 2-ethyl-6-methyl-3-hydroxypyridine succinate glucose absorption Science Q
Acceso en línea:	https://doaj.org/article/3f5c9eb2728d4a4c83581bc9f6bde983
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spelling	oai:doaj.org-article:3f5c9eb2728d4a4c83581bc9f6bde9832021-11-23T06:14:34ZOne of the possible mechanisms of glucose absorption slowing during immobilization stress2541-94202587-959610.12737/article_590823a4cb2e90.88690054https://doaj.org/article/3f5c9eb2728d4a4c83581bc9f6bde9832016-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/200https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596An experimental study was performed on outbred male rats. In the first series of chronic experiments we studied the process of glucose absorption in an isolated loop of a jejunum in 12 rats. In the second series we studied the changes of lipid peroxidation during immobilization with the introduction of MFB and without in 18 rats in each group. Rats were operated in a special way. During all the days of immobilization there is an increased DK in serum of rats, reaching maximum on the seventh day of daily one hour immobilization. Lipid peroxidation products (conjugated dienes, malonicdialdehyde) and antioxidant activity of serum in chronic immobilization stress (1 hour a day during 7 days) and glucose absorption in a jejunum were investigated. Activation of lipid peroxidation (LPO) and its correlation with inhibition of glucose absorption rate were revealed. 2-ethyl-6-methyl- 3-hydroxypyridine succinate (EMHPS) administration of a 10 mg/kg a day dose for 7 days resulted in primary and end lipid peroxidation product decrease and increase in blood serum antioxidant activity. Under EMHPS correction, the glucose absorption rate approached the control group level in chronic immobilization stress. Activation of lipid peroxidation was suggested as one of the possible mechanisms of glucose absorption reduction during stress. Activation of the POL can be one of the decline reasons of the glucose absorption process during stress.L. I. KorytovL. A. GrebyonkinaM. I. SuslikovaScientific Сentre for Family Health and Human Reproduction Problemsarticle2-этил-6-метил-3-оксипиридина сукцинатstresslipid peroxidation2-ethyl-6-methyl-3-hydroxypyridine succinateglucoseabsorptionScienceQRUActa Biomedica Scientifica, Vol 1, Iss 3(2), Pp 112-115 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	2-этил-6-метил-3-оксипиридина сукцинат stress lipid peroxidation 2-ethyl-6-methyl-3-hydroxypyridine succinate glucose absorption Science Q
spellingShingle	2-этил-6-метил-3-оксипиридина сукцинат stress lipid peroxidation 2-ethyl-6-methyl-3-hydroxypyridine succinate glucose absorption Science Q L. I. Korytov L. A. Grebyonkina M. I. Suslikova One of the possible mechanisms of glucose absorption slowing during immobilization stress
description	An experimental study was performed on outbred male rats. In the first series of chronic experiments we studied the process of glucose absorption in an isolated loop of a jejunum in 12 rats. In the second series we studied the changes of lipid peroxidation during immobilization with the introduction of MFB and without in 18 rats in each group. Rats were operated in a special way. During all the days of immobilization there is an increased DK in serum of rats, reaching maximum on the seventh day of daily one hour immobilization. Lipid peroxidation products (conjugated dienes, malonicdialdehyde) and antioxidant activity of serum in chronic immobilization stress (1 hour a day during 7 days) and glucose absorption in a jejunum were investigated. Activation of lipid peroxidation (LPO) and its correlation with inhibition of glucose absorption rate were revealed. 2-ethyl-6-methyl- 3-hydroxypyridine succinate (EMHPS) administration of a 10 mg/kg a day dose for 7 days resulted in primary and end lipid peroxidation product decrease and increase in blood serum antioxidant activity. Under EMHPS correction, the glucose absorption rate approached the control group level in chronic immobilization stress. Activation of lipid peroxidation was suggested as one of the possible mechanisms of glucose absorption reduction during stress. Activation of the POL can be one of the decline reasons of the glucose absorption process during stress.
format	article
author	L. I. Korytov L. A. Grebyonkina M. I. Suslikova
author_facet	L. I. Korytov L. A. Grebyonkina M. I. Suslikova
author_sort	L. I. Korytov
title	One of the possible mechanisms of glucose absorption slowing during immobilization stress
title_short	One of the possible mechanisms of glucose absorption slowing during immobilization stress
title_full	One of the possible mechanisms of glucose absorption slowing during immobilization stress
title_fullStr	One of the possible mechanisms of glucose absorption slowing during immobilization stress
title_full_unstemmed	One of the possible mechanisms of glucose absorption slowing during immobilization stress
title_sort	one of the possible mechanisms of glucose absorption slowing during immobilization stress
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/3f5c9eb2728d4a4c83581bc9f6bde983
work_keys_str_mv	AT likorytov oneofthepossiblemechanismsofglucoseabsorptionslowingduringimmobilizationstress AT lagrebyonkina oneofthepossiblemechanismsofglucoseabsorptionslowingduringimmobilizationstress AT misuslikova oneofthepossiblemechanismsofglucoseabsorptionslowingduringimmobilizationstress
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One of the possible mechanisms of glucose absorption slowing during immobilization stress

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