B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers

B cell progenitors differentiate into multiple subsets with distinct functions. Here the authors analyze the epigenetic landscapes of sorted B cell subsets using multiple platforms and show that the epigenetic regulator, DNMT3A, is essential for modulating the activity of enhancers critical for B1 a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Vinay S. Mahajan, Hamid Mattoo, Na Sun, Vinayak Viswanadham, Grace J. Yuen, Hugues Allard-Chamard, Maimuna Ahmad, Samuel J. H. Murphy, Annaiah Cariappa, Yesim Tuncay, Shiv Pillai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3f5d4b4a728a40e5ad631b0536b74c49
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3f5d4b4a728a40e5ad631b0536b74c49
record_format	dspace
spelling	oai:doaj.org-article:3f5d4b4a728a40e5ad631b0536b74c492021-12-02T15:51:06ZB1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers10.1038/s41467-021-22458-92041-1723https://doaj.org/article/3f5d4b4a728a40e5ad631b0536b74c492021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22458-9https://doaj.org/toc/2041-1723B cell progenitors differentiate into multiple subsets with distinct functions. Here the authors analyze the epigenetic landscapes of sorted B cell subsets using multiple platforms and show that the epigenetic regulator, DNMT3A, is essential for modulating the activity of enhancers critical for B1 and B2 lineage-determining genes.Vinay S. MahajanHamid MattooNa SunVinayak ViswanadhamGrace J. YuenHugues Allard-ChamardMaimuna AhmadSamuel J. H. MurphyAnnaiah CariappaYesim TuncayShiv PillaiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vinay S. Mahajan Hamid Mattoo Na Sun Vinayak Viswanadham Grace J. Yuen Hugues Allard-Chamard Maimuna Ahmad Samuel J. H. Murphy Annaiah Cariappa Yesim Tuncay Shiv Pillai B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers
description	B cell progenitors differentiate into multiple subsets with distinct functions. Here the authors analyze the epigenetic landscapes of sorted B cell subsets using multiple platforms and show that the epigenetic regulator, DNMT3A, is essential for modulating the activity of enhancers critical for B1 and B2 lineage-determining genes.
format	article
author	Vinay S. Mahajan Hamid Mattoo Na Sun Vinayak Viswanadham Grace J. Yuen Hugues Allard-Chamard Maimuna Ahmad Samuel J. H. Murphy Annaiah Cariappa Yesim Tuncay Shiv Pillai
author_facet	Vinay S. Mahajan Hamid Mattoo Na Sun Vinayak Viswanadham Grace J. Yuen Hugues Allard-Chamard Maimuna Ahmad Samuel J. H. Murphy Annaiah Cariappa Yesim Tuncay Shiv Pillai
author_sort	Vinay S. Mahajan
title	B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers
title_short	B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers
title_full	B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers
title_fullStr	B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers
title_full_unstemmed	B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers
title_sort	b1a and b2 cells are characterized by distinct cpg modification states at dnmt3a-maintained enhancers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3f5d4b4a728a40e5ad631b0536b74c49
work_keys_str_mv	AT vinaysmahajan b1aandb2cellsarecharacterizedbydistinctcpgmodificationstatesatdnmt3amaintainedenhancers AT hamidmattoo b1aandb2cellsarecharacterizedbydistinctcpgmodificationstatesatdnmt3amaintainedenhancers AT nasun b1aandb2cellsarecharacterizedbydistinctcpgmodificationstatesatdnmt3amaintainedenhancers AT vinayakviswanadham b1aandb2cellsarecharacterizedbydistinctcpgmodificationstatesatdnmt3amaintainedenhancers AT gracejyuen b1aandb2cellsarecharacterizedbydistinctcpgmodificationstatesatdnmt3amaintainedenhancers AT huguesallardchamard b1aandb2cellsarecharacterizedbydistinctcpgmodificationstatesatdnmt3amaintainedenhancers AT maimunaahmad b1aandb2cellsarecharacterizedbydistinctcpgmodificationstatesatdnmt3amaintainedenhancers AT samueljhmurphy b1aandb2cellsarecharacterizedbydistinctcpgmodificationstatesatdnmt3amaintainedenhancers AT annaiahcariappa b1aandb2cellsarecharacterizedbydistinctcpgmodificationstatesatdnmt3amaintainedenhancers AT yesimtuncay b1aandb2cellsarecharacterizedbydistinctcpgmodificationstatesatdnmt3amaintainedenhancers AT shivpillai b1aandb2cellsarecharacterizedbydistinctcpgmodificationstatesatdnmt3amaintainedenhancers
_version_	1718385628519858176

B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers

Ejemplares similares