B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers

B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers

B cell progenitors differentiate into multiple subsets with distinct functions. Here the authors analyze the epigenetic landscapes of sorted B cell subsets using multiple platforms and show that the epigenetic regulator, DNMT3A, is essential for modulating the activity of enhancers critical for B1 a...

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Autores principales: Vinay S. Mahajan, Hamid Mattoo, Na Sun, Vinayak Viswanadham, Grace J. Yuen, Hugues Allard-Chamard, Maimuna Ahmad, Samuel J. H. Murphy, Annaiah Cariappa, Yesim Tuncay, Shiv Pillai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/3f5d4b4a728a40e5ad631b0536b74c49
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